Enhanced antitumor immunity by targeting dendritic cells with tumor cell lysate-loaded chitosan nanoparticles vaccine

Abstract Whole tumor cell lysates (TCL) have been implemented as tumor antigens for cancer vaccine development, although clinical outcomes of TCL-based antitumor immunotherapy remain unsatisfactory. In order to improve the efficacy of TCL-based vaccines, biomaterials have been employed to enhance an...

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Veröffentlicht in:	Biomaterials 2017-01, Vol.113, p.191-202
Hauptverfasser:	Shi, Gaona, Zhang, Chuangnian, Xu, Rong, Niu, Jinfeng, Song, Huijuan, Zhang, Xiuyuan, Wang, Weiwei, Wang, Yanming, Li, Chen, Wei, Xiaoqing, Kong, Deling
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Animals Antigens Antigens, Neoplasm - administration & dosage Antigens, Neoplasm - immunology Antigens, Neoplasm - therapeutic use Cancer Cancer Vaccines - administration & dosage Cancer Vaccines - immunology Cancer Vaccines - therapeutic use Cell Line, Tumor Chitosan Chitosan - chemistry Dendritic cell targeting Dendritic Cells - immunology Dentistry Drug Carriers - chemistry Female Immunotherapy Melanoma, Experimental - immunology Melanoma, Experimental - pathology Melanoma, Experimental - therapy Mice Mice, Inbred BALB C Mice, Inbred C57BL Nano-vaccine Nanoparticles Nanoparticles - chemistry Surgical implants Tumor cell lysates Tumors Vaccines
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