The Role of Protein Loops and Linkers in Conformational Dynamics and Allostery

Proteins are dynamic entities that undergo a plethora of conformational changes that may take place on a wide range of time scales. These changes can be as small as the rotation of one or a few side-chain dihedral angles or involve concerted motions in larger portions of the three-dimensional struct...

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Veröffentlicht in:Chemical reviews 2016-06, Vol.116 (11), p.6391-6423
Hauptverfasser: Papaleo, Elena, Saladino, Giorgio, Lambrughi, Matteo, Lindorff-Larsen, Kresten, Gervasio, Francesco Luigi, Nussinov, Ruth
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Sprache:eng
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