Progress in the Synthesis and Bioactivity of Hexacoordinate Silicon(IV) Complexes
(Arenediolato)bis(polypyridyl)silicon(IV) complexes contain hexacoordinate silicon and are surprisingly stable against hydrolysis in water. In an ongoing research program, we are aiming to exploit them as new structural templates for the design of bioactive compounds. As a follow‐up to previous work...
Gespeichert in:
| Veröffentlicht in: | European journal of inorganic chemistry 2016-11, Vol.2016 (32), p.5161-5170 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 5170 |
|---|---|
| container_issue | 32 |
| container_start_page | 5161 |
| container_title | European journal of inorganic chemistry |
| container_volume | 2016 |
| creator | Henker, Jens Wirmer-Bartoschek, Julia Bendel, Lars Erik Xiang, Yonggang Fu, Chen Harms, Klaus Schwalbe, Harald Meggers, Eric |
| description | (Arenediolato)bis(polypyridyl)silicon(IV) complexes contain hexacoordinate silicon and are surprisingly stable against hydrolysis in water. In an ongoing research program, we are aiming to exploit them as new structural templates for the design of bioactive compounds. As a follow‐up to previous work, here we present our progress in the synthesis of hexacoordinate silicon complexes by selective ortho‐double nitration of the electron‐rich catecholato ligand, followed by reduction to diamines and condensation either with 1,2‐diketones or with aldehydes. Binding epitopes of some representative complexes to G‐quadruplex DNA as determined by NMR spectroscopic titration are presented.
(Arenediolato)bis(polypyridyl)silicon(IV) complexes were selectively functionalized through a bis‐nitration/reduction/condensation protocol and investigated for their binding to DNA G‐quadruplexes. |
| doi_str_mv | 10.1002/ejic.201600953 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1864561928</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1864561928</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3603-6cd14839d3b00c9906b4156ed7bd8bf688b896ef613accea12c190811cb57af93</originalsourceid><addsrcrecordid>eNqFkMFPwjAUhxejiYhePe-Ih-HrunXtUQkCBhWC4rHpuk6LY8V2KPvvHZkh3jz93uH73uHzvEsEfQQQXquVlv0QEAFgMT7yOggYC4DQ8Li5IxwFiEX01DtzbgUAGDDpePOZNW9WOefr0q_elb-oy2acdr4oM_9WGyEr_aWr2je5P1Y7IY2xmS5F1bC60NKUvcnyyh-Y9aZQO-XOvZNcFE5d_G7Xe7kbPg_GwfRpNBncTAOJCeCAyAxFFLMMpwCSMSBphGKisiTNaJoTSlPKiMoJwkJKJVAoEQOKkEzjROQMd71e-3djzedWuYqvtZOqKESpzNZxREkUE8RC2qD9FpXWOGdVzjdWr4WtOQK-b8f37fihXSOwVvjWhar_ofnwfjL46watq12ldgdX2A9OEpzE_PVxxCPM0Hy2WPIH_ANLFIIp</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1864561928</pqid></control><display><type>article</type><title>Progress in the Synthesis and Bioactivity of Hexacoordinate Silicon(IV) Complexes</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Henker, Jens ; Wirmer-Bartoschek, Julia ; Bendel, Lars Erik ; Xiang, Yonggang ; Fu, Chen ; Harms, Klaus ; Schwalbe, Harald ; Meggers, Eric</creator><creatorcontrib>Henker, Jens ; Wirmer-Bartoschek, Julia ; Bendel, Lars Erik ; Xiang, Yonggang ; Fu, Chen ; Harms, Klaus ; Schwalbe, Harald ; Meggers, Eric</creatorcontrib><description>(Arenediolato)bis(polypyridyl)silicon(IV) complexes contain hexacoordinate silicon and are surprisingly stable against hydrolysis in water. In an ongoing research program, we are aiming to exploit them as new structural templates for the design of bioactive compounds. As a follow‐up to previous work, here we present our progress in the synthesis of hexacoordinate silicon complexes by selective ortho‐double nitration of the electron‐rich catecholato ligand, followed by reduction to diamines and condensation either with 1,2‐diketones or with aldehydes. Binding epitopes of some representative complexes to G‐quadruplex DNA as determined by NMR spectroscopic titration are presented.
(Arenediolato)bis(polypyridyl)silicon(IV) complexes were selectively functionalized through a bis‐nitration/reduction/condensation protocol and investigated for their binding to DNA G‐quadruplexes.</description><identifier>ISSN: 1434-1948</identifier><identifier>EISSN: 1099-0682</identifier><identifier>DOI: 10.1002/ejic.201600953</identifier><language>eng</language><publisher>Blackwell Publishing Ltd</publisher><subject>Binding ; Biochemistry ; Condensation ; Deoxyribonucleic acid ; DNA quadruplexes ; Hexacoordination ; Ligands ; Nitration ; NMR spectroscopy ; Reduction ; Silicon ; Synthesis</subject><ispartof>European journal of inorganic chemistry, 2016-11, Vol.2016 (32), p.5161-5170</ispartof><rights>2016 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3603-6cd14839d3b00c9906b4156ed7bd8bf688b896ef613accea12c190811cb57af93</citedby><cites>FETCH-LOGICAL-c3603-6cd14839d3b00c9906b4156ed7bd8bf688b896ef613accea12c190811cb57af93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fejic.201600953$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fejic.201600953$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids></links><search><creatorcontrib>Henker, Jens</creatorcontrib><creatorcontrib>Wirmer-Bartoschek, Julia</creatorcontrib><creatorcontrib>Bendel, Lars Erik</creatorcontrib><creatorcontrib>Xiang, Yonggang</creatorcontrib><creatorcontrib>Fu, Chen</creatorcontrib><creatorcontrib>Harms, Klaus</creatorcontrib><creatorcontrib>Schwalbe, Harald</creatorcontrib><creatorcontrib>Meggers, Eric</creatorcontrib><title>Progress in the Synthesis and Bioactivity of Hexacoordinate Silicon(IV) Complexes</title><title>European journal of inorganic chemistry</title><addtitle>Eur. J. Inorg. Chem</addtitle><description>(Arenediolato)bis(polypyridyl)silicon(IV) complexes contain hexacoordinate silicon and are surprisingly stable against hydrolysis in water. In an ongoing research program, we are aiming to exploit them as new structural templates for the design of bioactive compounds. As a follow‐up to previous work, here we present our progress in the synthesis of hexacoordinate silicon complexes by selective ortho‐double nitration of the electron‐rich catecholato ligand, followed by reduction to diamines and condensation either with 1,2‐diketones or with aldehydes. Binding epitopes of some representative complexes to G‐quadruplex DNA as determined by NMR spectroscopic titration are presented.
(Arenediolato)bis(polypyridyl)silicon(IV) complexes were selectively functionalized through a bis‐nitration/reduction/condensation protocol and investigated for their binding to DNA G‐quadruplexes.</description><subject>Binding</subject><subject>Biochemistry</subject><subject>Condensation</subject><subject>Deoxyribonucleic acid</subject><subject>DNA quadruplexes</subject><subject>Hexacoordination</subject><subject>Ligands</subject><subject>Nitration</subject><subject>NMR spectroscopy</subject><subject>Reduction</subject><subject>Silicon</subject><subject>Synthesis</subject><issn>1434-1948</issn><issn>1099-0682</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqFkMFPwjAUhxejiYhePe-Ih-HrunXtUQkCBhWC4rHpuk6LY8V2KPvvHZkh3jz93uH73uHzvEsEfQQQXquVlv0QEAFgMT7yOggYC4DQ8Li5IxwFiEX01DtzbgUAGDDpePOZNW9WOefr0q_elb-oy2acdr4oM_9WGyEr_aWr2je5P1Y7IY2xmS5F1bC60NKUvcnyyh-Y9aZQO-XOvZNcFE5d_G7Xe7kbPg_GwfRpNBncTAOJCeCAyAxFFLMMpwCSMSBphGKisiTNaJoTSlPKiMoJwkJKJVAoEQOKkEzjROQMd71e-3djzedWuYqvtZOqKESpzNZxREkUE8RC2qD9FpXWOGdVzjdWr4WtOQK-b8f37fihXSOwVvjWhar_ofnwfjL46watq12ldgdX2A9OEpzE_PVxxCPM0Hy2WPIH_ANLFIIp</recordid><startdate>201611</startdate><enddate>201611</enddate><creator>Henker, Jens</creator><creator>Wirmer-Bartoschek, Julia</creator><creator>Bendel, Lars Erik</creator><creator>Xiang, Yonggang</creator><creator>Fu, Chen</creator><creator>Harms, Klaus</creator><creator>Schwalbe, Harald</creator><creator>Meggers, Eric</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>201611</creationdate><title>Progress in the Synthesis and Bioactivity of Hexacoordinate Silicon(IV) Complexes</title><author>Henker, Jens ; Wirmer-Bartoschek, Julia ; Bendel, Lars Erik ; Xiang, Yonggang ; Fu, Chen ; Harms, Klaus ; Schwalbe, Harald ; Meggers, Eric</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3603-6cd14839d3b00c9906b4156ed7bd8bf688b896ef613accea12c190811cb57af93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Binding</topic><topic>Biochemistry</topic><topic>Condensation</topic><topic>Deoxyribonucleic acid</topic><topic>DNA quadruplexes</topic><topic>Hexacoordination</topic><topic>Ligands</topic><topic>Nitration</topic><topic>NMR spectroscopy</topic><topic>Reduction</topic><topic>Silicon</topic><topic>Synthesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Henker, Jens</creatorcontrib><creatorcontrib>Wirmer-Bartoschek, Julia</creatorcontrib><creatorcontrib>Bendel, Lars Erik</creatorcontrib><creatorcontrib>Xiang, Yonggang</creatorcontrib><creatorcontrib>Fu, Chen</creatorcontrib><creatorcontrib>Harms, Klaus</creatorcontrib><creatorcontrib>Schwalbe, Harald</creatorcontrib><creatorcontrib>Meggers, Eric</creatorcontrib><collection>Istex</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>European journal of inorganic chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Henker, Jens</au><au>Wirmer-Bartoschek, Julia</au><au>Bendel, Lars Erik</au><au>Xiang, Yonggang</au><au>Fu, Chen</au><au>Harms, Klaus</au><au>Schwalbe, Harald</au><au>Meggers, Eric</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Progress in the Synthesis and Bioactivity of Hexacoordinate Silicon(IV) Complexes</atitle><jtitle>European journal of inorganic chemistry</jtitle><addtitle>Eur. J. Inorg. Chem</addtitle><date>2016-11</date><risdate>2016</risdate><volume>2016</volume><issue>32</issue><spage>5161</spage><epage>5170</epage><pages>5161-5170</pages><issn>1434-1948</issn><eissn>1099-0682</eissn><abstract>(Arenediolato)bis(polypyridyl)silicon(IV) complexes contain hexacoordinate silicon and are surprisingly stable against hydrolysis in water. In an ongoing research program, we are aiming to exploit them as new structural templates for the design of bioactive compounds. As a follow‐up to previous work, here we present our progress in the synthesis of hexacoordinate silicon complexes by selective ortho‐double nitration of the electron‐rich catecholato ligand, followed by reduction to diamines and condensation either with 1,2‐diketones or with aldehydes. Binding epitopes of some representative complexes to G‐quadruplex DNA as determined by NMR spectroscopic titration are presented.
(Arenediolato)bis(polypyridyl)silicon(IV) complexes were selectively functionalized through a bis‐nitration/reduction/condensation protocol and investigated for their binding to DNA G‐quadruplexes.</abstract><pub>Blackwell Publishing Ltd</pub><doi>10.1002/ejic.201600953</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1434-1948 |
| ispartof | European journal of inorganic chemistry, 2016-11, Vol.2016 (32), p.5161-5170 |
| issn | 1434-1948 1099-0682 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1864561928 |
| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Binding Biochemistry Condensation Deoxyribonucleic acid DNA quadruplexes Hexacoordination Ligands Nitration NMR spectroscopy Reduction Silicon Synthesis |
| title | Progress in the Synthesis and Bioactivity of Hexacoordinate Silicon(IV) Complexes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T02%3A14%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Progress%20in%20the%20Synthesis%20and%20Bioactivity%20of%20Hexacoordinate%20Silicon(IV)%20Complexes&rft.jtitle=European%20journal%20of%20inorganic%20chemistry&rft.au=Henker,%20Jens&rft.date=2016-11&rft.volume=2016&rft.issue=32&rft.spage=5161&rft.epage=5170&rft.pages=5161-5170&rft.issn=1434-1948&rft.eissn=1099-0682&rft_id=info:doi/10.1002/ejic.201600953&rft_dat=%3Cproquest_cross%3E1864561928%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1864561928&rft_id=info:pmid/&rfr_iscdi=true |