Synthesis of Enantiomerically Enriched Amino Acids Containing Acetylenic Bond in the Side-Chain Radical

Synthesis of Enantiomerically Enriched Amino Acids Containing Acetylenic Bond in the Side-Chain Radical

An efficient method for the asymmetric synthesis of enantiomerically enriched derivatives of (S)-propargylglycine by С -alkylation of NiII-complex of Schiff's bases of propargylglycine and chiral auxiliary (S)-2-N-[N'-(benzylprolyl) amino] benzophenone with benzyl bromide and its derivativ...

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Veröffentlicht in:International journal of chemical engineering and applications (IJCEA) 2016-12, Vol.7 (6), p.413-416
Hauptverfasser: Saghyan, Ashot. S., Mkrtchyan, Anna F., Karapetyan, Ani J., Mardiyan, Zorayr Z., Hayriyan, Liana A., Simonyan, Hayarpi M.
Format: Artikel
Sprache:eng
Schlagworte:
Amino acids
Asymmetry
Benzyl bromide
Bonding
Chemical engineering
Derivatives
Enrichment
Synthesis
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Beschreibung
Zusammenfassung:An efficient method for the asymmetric synthesis of enantiomerically enriched derivatives of (S)-propargylglycine by С -alkylation of NiII-complex of Schiff's bases of propargylglycine and chiral auxiliary (S)-2-N-[N'-(benzylprolyl) amino] benzophenone with benzyl bromide and its derivatives (de 85-90 %) has been developed. This resulted in synthesis of new enantiomerically enriched alpha -amino acids containing acetylenic bond in the side chain (ee >95%).
ISSN:2010-0221
DOI:10.18178/ijcea.2016.7.6.616