$A large fraction of HLA class I ligands are proteasome-generated spliced peptides$

A large fraction of HLA class I ligands are proteasome-generated spliced peptides

The proteasome generates the epitopes presented on human leukocyte antigen (HLA) class I molecules that elicit CD8⁺ T cell responses. Reports of proteasome-generated spliced epitopes exist, but they have been regarded as rare events. Here, however, we show that the proteasome-generated spliced pepti...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2016-10, Vol.354 (6310), p.354-358
Hauptverfasser:	Liepe, Juliane, Marino, Fabio, Sidney, John, Jeko, Anita, Bunting, Daniel E., Sette, Alessandro, Kloetzel, Peter M., Stumpf, Michael P. H., Heck, Albert J. R., Mishto, Michele
Format:	Artikel
Sprache:	eng
Schlagworte:	Abundance Antigen Presentation Antigens Cancer CD8-Positive T-Lymphocytes - immunology Cell Line, Tumor Computational Biology Epitopes, T-Lymphocyte - metabolism Histocompatibility Antigens Class I - metabolism Humans Immunology Ligands Lymphocytes Peptides Peptides - immunology Peptides - metabolism Pools Proteasome Endopeptidase Complex - metabolism Protein Splicing Vaccines
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