Core-shell alginate[at]silica microparticles encapsulating probiotics
Lactobacillus rhamnosus GG (LGG) was encapsulated in core-shell alginate-silica microcapsules by coating the electrosprayed ionogel with a silica shell via hydrolysis/condensation of alkoxysilane precursors. The viability of encapsulated LGG highly depends on the mineralisation conditions (in aqueou...
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| Veröffentlicht in: | Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2016-12, Vol.4 (48), p.7929-7935 |
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| container_end_page | 7935 |
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| container_issue | 48 |
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| container_title | Journal of materials chemistry. B, Materials for biology and medicine |
| container_volume | 4 |
| creator | Haffner, F B Girardon, M Fontanay, S Canilho, N Duval, R E Mierzwa, M Etienne, M Diab, R Pasc, A |
| description | Lactobacillus rhamnosus GG (LGG) was encapsulated in core-shell alginate-silica microcapsules by coating the electrosprayed ionogel with a silica shell via hydrolysis/condensation of alkoxysilane precursors. The viability of encapsulated LGG highly depends on the mineralisation conditions (in aqueous or organic phases), identified as a critical step. More importantly, due to the unswelling of silica and to its mesoporosity that allows nutriment-metabolite diffusion, it was possible to avoid cell leakage and additionally insure bacterial growth inside the microcapsules. The results of this work gave a proof-of-concept for controlled bacterial proliferation in microcompartments, which have straightforward applications in oral delivery of probiotics. |
| doi_str_mv | 10.1039/c6tb02802k |
| format | Article |
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The viability of encapsulated LGG highly depends on the mineralisation conditions (in aqueous or organic phases), identified as a critical step. More importantly, due to the unswelling of silica and to its mesoporosity that allows nutriment-metabolite diffusion, it was possible to avoid cell leakage and additionally insure bacterial growth inside the microcapsules. The results of this work gave a proof-of-concept for controlled bacterial proliferation in microcompartments, which have straightforward applications in oral delivery of probiotics.</description><identifier>ISSN: 2050-750X</identifier><identifier>EISSN: 2050-7518</identifier><identifier>DOI: 10.1039/c6tb02802k</identifier><language>eng</language><subject>Bacteria ; Encapsulating ; Encapsulation ; Lactobacillus rhamnosus ; Leakage ; Probiotics ; Silicon dioxide ; Viability</subject><ispartof>Journal of materials chemistry. 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B, Materials for biology and medicine</title><description>Lactobacillus rhamnosus GG (LGG) was encapsulated in core-shell alginate-silica microcapsules by coating the electrosprayed ionogel with a silica shell via hydrolysis/condensation of alkoxysilane precursors. The viability of encapsulated LGG highly depends on the mineralisation conditions (in aqueous or organic phases), identified as a critical step. More importantly, due to the unswelling of silica and to its mesoporosity that allows nutriment-metabolite diffusion, it was possible to avoid cell leakage and additionally insure bacterial growth inside the microcapsules. The results of this work gave a proof-of-concept for controlled bacterial proliferation in microcompartments, which have straightforward applications in oral delivery of probiotics.</description><subject>Bacteria</subject><subject>Encapsulating</subject><subject>Encapsulation</subject><subject>Lactobacillus rhamnosus</subject><subject>Leakage</subject><subject>Probiotics</subject><subject>Silicon dioxide</subject><subject>Viability</subject><issn>2050-750X</issn><issn>2050-7518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqNjk9LAzEQxYMoWGovfoI9elmdbP5sepSlVqHgpQdBpEzSbI2mu-tO9vsbsXh2LvMeb5jfY-yawy0HsbxzOlmoDFSfZ2xWgYKyVtyc_2l4uWQLog_IY7g2Qs7YqulHX9K7j7HAeAgdJv-K6Y1CDA6LY3BjP-CYgoueCt85HGiKmEJ3KIaxt6HPEV2xixYj-cVpz9n2YbVtHsvN8_qpud-Ug9a8rFAqzmXrrAGR-bbVLXi5VDbrGn2txI9HXTnTgsC9AnCmhr202Uor5uzm920mf02e0u4YyOXq2Pl-oh03WiphOPB_nCoFRiqpxTdxo128</recordid><startdate>20161201</startdate><enddate>20161201</enddate><creator>Haffner, F B</creator><creator>Girardon, M</creator><creator>Fontanay, S</creator><creator>Canilho, N</creator><creator>Duval, R E</creator><creator>Mierzwa, M</creator><creator>Etienne, M</creator><creator>Diab, R</creator><creator>Pasc, A</creator><scope>7QL</scope><scope>7QO</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20161201</creationdate><title>Core-shell alginate[at]silica microparticles encapsulating probiotics</title><author>Haffner, F B ; Girardon, M ; Fontanay, S ; Canilho, N ; Duval, R E ; Mierzwa, M ; Etienne, M ; Diab, R ; Pasc, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p661-2a45114fcb803168bf6f0e495b68b7ae753f0e4a62c8f03ad500c870d4bf034b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Bacteria</topic><topic>Encapsulating</topic><topic>Encapsulation</topic><topic>Lactobacillus rhamnosus</topic><topic>Leakage</topic><topic>Probiotics</topic><topic>Silicon dioxide</topic><topic>Viability</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Haffner, F B</creatorcontrib><creatorcontrib>Girardon, M</creatorcontrib><creatorcontrib>Fontanay, S</creatorcontrib><creatorcontrib>Canilho, N</creatorcontrib><creatorcontrib>Duval, R E</creatorcontrib><creatorcontrib>Mierzwa, M</creatorcontrib><creatorcontrib>Etienne, M</creatorcontrib><creatorcontrib>Diab, R</creatorcontrib><creatorcontrib>Pasc, A</creatorcontrib><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Journal of materials chemistry. 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| fulltext | fulltext |
| identifier | ISSN: 2050-750X |
| ispartof | Journal of materials chemistry. B, Materials for biology and medicine, 2016-12, Vol.4 (48), p.7929-7935 |
| issn | 2050-750X 2050-7518 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1864538101 |
| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Bacteria Encapsulating Encapsulation Lactobacillus rhamnosus Leakage Probiotics Silicon dioxide Viability |
| title | Core-shell alginate[at]silica microparticles encapsulating probiotics |
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