Co-occurrence of mobile genetic elements and antibiotic resistance genes in municipal solid waste landfill leachates: A preliminary insight into the role of landfill age
Since municipal solid waste (MSW) landfill harbours miscellaneous wastes, pollutants and microorganisms, it gradually becomes a huge potential reservoir for breeding antibiotic resistance genes (ARGs). The objective of this study was to determine the prevalence and diversity of ARGs associated with...
Gespeichert in:
| Veröffentlicht in: | Water research (Oxford) 2016-12, Vol.106, p.583-592 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 592 |
|---|---|
| container_issue | |
| container_start_page | 583 |
| container_title | Water research (Oxford) |
| container_volume | 106 |
| creator | Yu, Zhuofeng He, Pinjing Shao, Liming Zhang, Hua Lü, Fan |
| description | Since municipal solid waste (MSW) landfill harbours miscellaneous wastes, pollutants and microorganisms, it gradually becomes a huge potential reservoir for breeding antibiotic resistance genes (ARGs). The objective of this study was to determine the prevalence and diversity of ARGs associated with various mobile genetic elements (MGEs) in MSW landfill leachates. The relationship of ARGs with leachate characteristics was also studied to explore the influence of landfill age. Seven sulfonamides (sulfapyridine, sulfadiazine, sulfathiazole, sulfamethoxazole, sulfamerazine, sulfamethazine and sulfaquinoxaline), three encoded ARGs (sul-I, sul-II and sul-III) and four types of MGEs (plasmids, transposons, integrons and insertion sequences) were quantified in leachates with landfill ages ranging from 3 months–6 years. ARGs increased to an absolute concentration of 106 copies/μL and were positively correlated (p |
| doi_str_mv | 10.1016/j.watres.2016.10.042 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1864535944</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0043135416307953</els_id><sourcerecordid>1864535944</sourcerecordid><originalsourceid>FETCH-LOGICAL-c428t-e7da634de5fd1aaa08057af8c36104fbef83cbe412276d00cacaa528079a861f3</originalsourceid><addsrcrecordid>eNqNkc9u1DAQxi1ERbeFN0DIRy5Z_C-JlwNStSoFqVIvcLYcZ7I7KydebIeqj8Rb1mFLj6gHa-TR75tvNB8h7zlbc8abT4f1vc0R0lqUX2mtmRKvyIrrdlMJpfRrsmJMyYrLWp2Ti5QOjDEh5OYNORdt2zaStSvyZxuq4NwcI0wOaBjoGDr0QHcwQUZHwcMIU07UTn15GTsMS784Y8p2ES1oojjRcZ7Q4dF6moLHnt7blIH6ohzQe-rBur3NkD7TK3qM4HHEycaHIk242-dSc6B5DzQG_3eXZ6ndwVtyNlif4N1TvSQ_v17_2H6rbu9uvm-vbiunhM4VtL1tpOqhHnpurWWa1a0dtJMNZ2roYNDSdaC4EG3TM-ass7YWmrUbqxs-yEvy8TT3GMOvGVI2IyYHvuwCYU6G60bVst4o9QJUNYpzwV-CyrrRZSorqDqhLoaUIgzmGHEsdzKcmSV6czCn6M0S_dIt0RfZhyeHuRuhfxb9y7oAX04AlOv9RogmOVxS7zGCy6YP-H-HR79IxOE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1835685940</pqid></control><display><type>article</type><title>Co-occurrence of mobile genetic elements and antibiotic resistance genes in municipal solid waste landfill leachates: A preliminary insight into the role of landfill age</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Yu, Zhuofeng ; He, Pinjing ; Shao, Liming ; Zhang, Hua ; Lü, Fan</creator><creatorcontrib>Yu, Zhuofeng ; He, Pinjing ; Shao, Liming ; Zhang, Hua ; Lü, Fan</creatorcontrib><description>Since municipal solid waste (MSW) landfill harbours miscellaneous wastes, pollutants and microorganisms, it gradually becomes a huge potential reservoir for breeding antibiotic resistance genes (ARGs). The objective of this study was to determine the prevalence and diversity of ARGs associated with various mobile genetic elements (MGEs) in MSW landfill leachates. The relationship of ARGs with leachate characteristics was also studied to explore the influence of landfill age. Seven sulfonamides (sulfapyridine, sulfadiazine, sulfathiazole, sulfamethoxazole, sulfamerazine, sulfamethazine and sulfaquinoxaline), three encoded ARGs (sul-I, sul-II and sul-III) and four types of MGEs (plasmids, transposons, integrons and insertion sequences) were quantified in leachates with landfill ages ranging from 3 months–6 years. ARGs increased to an absolute concentration of 106 copies/μL and were positively correlated (p < 0.05) to MGEs. Significant correlations (p < 0.05) were also discovered among ARGs and the increasing humic acids, heavy metals (Zn, Cu and Co) and antibiotics (except for sulfathiazole and sulfaquinoxaline), implying landfilling might contribute to the enrichment of ARGs in the long-term. Non-target full scans revealed the role of persistent unknown compounds in stimulating the ARGs dissemination. Overall, this study demonstrates the exacerbation of ARGs pollution in landfill environment and a detailed delineation of the complex inter-relationships between ARGs and the substances harbouring in landfills is badly required.
[Display omitted]
•ARGs copies increase with the age of MSW landfill leachates.•ARGs copies positively correlate to antibiotics, heavy metals and MGEs.•MGEs in landfills facilitate the prolonged HGT in dissemination of ARGs.•Non-target full scans reveal the role of unknown compounds in promoting ARGs.•Humic acids plays the vital role in stimulating ARGs in the long-term.</description><identifier>ISSN: 0043-1354</identifier><identifier>EISSN: 1879-2448</identifier><identifier>DOI: 10.1016/j.watres.2016.10.042</identifier><identifier>PMID: 27776307</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Age ; Anti-Bacterial Agents - pharmacology ; Antibiotic resistance genes ; Antibiotics ; Correlation ; Drug Resistance, Microbial - genetics ; Genetics ; Horizontal gene transfer ; Landfill age ; Landfills ; Leachates ; Mobile genetic elements ; Municipal landfills ; Municipal solid waste landfill leachates ; Refuse Disposal ; Solid Waste ; Solid waste management ; Waste Disposal Facilities ; Water Pollutants, Chemical</subject><ispartof>Water research (Oxford), 2016-12, Vol.106, p.583-592</ispartof><rights>2016 Elsevier Ltd</rights><rights>Copyright © 2016 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-e7da634de5fd1aaa08057af8c36104fbef83cbe412276d00cacaa528079a861f3</citedby><cites>FETCH-LOGICAL-c428t-e7da634de5fd1aaa08057af8c36104fbef83cbe412276d00cacaa528079a861f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0043135416307953$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27776307$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yu, Zhuofeng</creatorcontrib><creatorcontrib>He, Pinjing</creatorcontrib><creatorcontrib>Shao, Liming</creatorcontrib><creatorcontrib>Zhang, Hua</creatorcontrib><creatorcontrib>Lü, Fan</creatorcontrib><title>Co-occurrence of mobile genetic elements and antibiotic resistance genes in municipal solid waste landfill leachates: A preliminary insight into the role of landfill age</title><title>Water research (Oxford)</title><addtitle>Water Res</addtitle><description>Since municipal solid waste (MSW) landfill harbours miscellaneous wastes, pollutants and microorganisms, it gradually becomes a huge potential reservoir for breeding antibiotic resistance genes (ARGs). The objective of this study was to determine the prevalence and diversity of ARGs associated with various mobile genetic elements (MGEs) in MSW landfill leachates. The relationship of ARGs with leachate characteristics was also studied to explore the influence of landfill age. Seven sulfonamides (sulfapyridine, sulfadiazine, sulfathiazole, sulfamethoxazole, sulfamerazine, sulfamethazine and sulfaquinoxaline), three encoded ARGs (sul-I, sul-II and sul-III) and four types of MGEs (plasmids, transposons, integrons and insertion sequences) were quantified in leachates with landfill ages ranging from 3 months–6 years. ARGs increased to an absolute concentration of 106 copies/μL and were positively correlated (p < 0.05) to MGEs. Significant correlations (p < 0.05) were also discovered among ARGs and the increasing humic acids, heavy metals (Zn, Cu and Co) and antibiotics (except for sulfathiazole and sulfaquinoxaline), implying landfilling might contribute to the enrichment of ARGs in the long-term. Non-target full scans revealed the role of persistent unknown compounds in stimulating the ARGs dissemination. Overall, this study demonstrates the exacerbation of ARGs pollution in landfill environment and a detailed delineation of the complex inter-relationships between ARGs and the substances harbouring in landfills is badly required.
[Display omitted]
•ARGs copies increase with the age of MSW landfill leachates.•ARGs copies positively correlate to antibiotics, heavy metals and MGEs.•MGEs in landfills facilitate the prolonged HGT in dissemination of ARGs.•Non-target full scans reveal the role of unknown compounds in promoting ARGs.•Humic acids plays the vital role in stimulating ARGs in the long-term.</description><subject>Age</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibiotic resistance genes</subject><subject>Antibiotics</subject><subject>Correlation</subject><subject>Drug Resistance, Microbial - genetics</subject><subject>Genetics</subject><subject>Horizontal gene transfer</subject><subject>Landfill age</subject><subject>Landfills</subject><subject>Leachates</subject><subject>Mobile genetic elements</subject><subject>Municipal landfills</subject><subject>Municipal solid waste landfill leachates</subject><subject>Refuse Disposal</subject><subject>Solid Waste</subject><subject>Solid waste management</subject><subject>Waste Disposal Facilities</subject><subject>Water Pollutants, Chemical</subject><issn>0043-1354</issn><issn>1879-2448</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc9u1DAQxi1ERbeFN0DIRy5Z_C-JlwNStSoFqVIvcLYcZ7I7KydebIeqj8Rb1mFLj6gHa-TR75tvNB8h7zlbc8abT4f1vc0R0lqUX2mtmRKvyIrrdlMJpfRrsmJMyYrLWp2Ti5QOjDEh5OYNORdt2zaStSvyZxuq4NwcI0wOaBjoGDr0QHcwQUZHwcMIU07UTn15GTsMS784Y8p2ES1oojjRcZ7Q4dF6moLHnt7blIH6ohzQe-rBur3NkD7TK3qM4HHEycaHIk242-dSc6B5DzQG_3eXZ6ndwVtyNlif4N1TvSQ_v17_2H6rbu9uvm-vbiunhM4VtL1tpOqhHnpurWWa1a0dtJMNZ2roYNDSdaC4EG3TM-ass7YWmrUbqxs-yEvy8TT3GMOvGVI2IyYHvuwCYU6G60bVst4o9QJUNYpzwV-CyrrRZSorqDqhLoaUIgzmGHEsdzKcmSV6czCn6M0S_dIt0RfZhyeHuRuhfxb9y7oAX04AlOv9RogmOVxS7zGCy6YP-H-HR79IxOE</recordid><startdate>20161201</startdate><enddate>20161201</enddate><creator>Yu, Zhuofeng</creator><creator>He, Pinjing</creator><creator>Shao, Liming</creator><creator>Zhang, Hua</creator><creator>Lü, Fan</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QH</scope><scope>7TV</scope><scope>7UA</scope><scope>C1K</scope><scope>F1W</scope><scope>H97</scope><scope>L.G</scope><scope>8FD</scope><scope>FR3</scope><scope>KR7</scope></search><sort><creationdate>20161201</creationdate><title>Co-occurrence of mobile genetic elements and antibiotic resistance genes in municipal solid waste landfill leachates: A preliminary insight into the role of landfill age</title><author>Yu, Zhuofeng ; He, Pinjing ; Shao, Liming ; Zhang, Hua ; Lü, Fan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-e7da634de5fd1aaa08057af8c36104fbef83cbe412276d00cacaa528079a861f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Age</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibiotic resistance genes</topic><topic>Antibiotics</topic><topic>Correlation</topic><topic>Drug Resistance, Microbial - genetics</topic><topic>Genetics</topic><topic>Horizontal gene transfer</topic><topic>Landfill age</topic><topic>Landfills</topic><topic>Leachates</topic><topic>Mobile genetic elements</topic><topic>Municipal landfills</topic><topic>Municipal solid waste landfill leachates</topic><topic>Refuse Disposal</topic><topic>Solid Waste</topic><topic>Solid waste management</topic><topic>Waste Disposal Facilities</topic><topic>Water Pollutants, Chemical</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yu, Zhuofeng</creatorcontrib><creatorcontrib>He, Pinjing</creatorcontrib><creatorcontrib>Shao, Liming</creatorcontrib><creatorcontrib>Zhang, Hua</creatorcontrib><creatorcontrib>Lü, Fan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Aqualine</collection><collection>Pollution Abstracts</collection><collection>Water Resources Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Civil Engineering Abstracts</collection><jtitle>Water research (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yu, Zhuofeng</au><au>He, Pinjing</au><au>Shao, Liming</au><au>Zhang, Hua</au><au>Lü, Fan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Co-occurrence of mobile genetic elements and antibiotic resistance genes in municipal solid waste landfill leachates: A preliminary insight into the role of landfill age</atitle><jtitle>Water research (Oxford)</jtitle><addtitle>Water Res</addtitle><date>2016-12-01</date><risdate>2016</risdate><volume>106</volume><spage>583</spage><epage>592</epage><pages>583-592</pages><issn>0043-1354</issn><eissn>1879-2448</eissn><abstract>Since municipal solid waste (MSW) landfill harbours miscellaneous wastes, pollutants and microorganisms, it gradually becomes a huge potential reservoir for breeding antibiotic resistance genes (ARGs). The objective of this study was to determine the prevalence and diversity of ARGs associated with various mobile genetic elements (MGEs) in MSW landfill leachates. The relationship of ARGs with leachate characteristics was also studied to explore the influence of landfill age. Seven sulfonamides (sulfapyridine, sulfadiazine, sulfathiazole, sulfamethoxazole, sulfamerazine, sulfamethazine and sulfaquinoxaline), three encoded ARGs (sul-I, sul-II and sul-III) and four types of MGEs (plasmids, transposons, integrons and insertion sequences) were quantified in leachates with landfill ages ranging from 3 months–6 years. ARGs increased to an absolute concentration of 106 copies/μL and were positively correlated (p < 0.05) to MGEs. Significant correlations (p < 0.05) were also discovered among ARGs and the increasing humic acids, heavy metals (Zn, Cu and Co) and antibiotics (except for sulfathiazole and sulfaquinoxaline), implying landfilling might contribute to the enrichment of ARGs in the long-term. Non-target full scans revealed the role of persistent unknown compounds in stimulating the ARGs dissemination. Overall, this study demonstrates the exacerbation of ARGs pollution in landfill environment and a detailed delineation of the complex inter-relationships between ARGs and the substances harbouring in landfills is badly required.
[Display omitted]
•ARGs copies increase with the age of MSW landfill leachates.•ARGs copies positively correlate to antibiotics, heavy metals and MGEs.•MGEs in landfills facilitate the prolonged HGT in dissemination of ARGs.•Non-target full scans reveal the role of unknown compounds in promoting ARGs.•Humic acids plays the vital role in stimulating ARGs in the long-term.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>27776307</pmid><doi>10.1016/j.watres.2016.10.042</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0043-1354 |
| ispartof | Water research (Oxford), 2016-12, Vol.106, p.583-592 |
| issn | 0043-1354 1879-2448 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1864535944 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Age Anti-Bacterial Agents - pharmacology Antibiotic resistance genes Antibiotics Correlation Drug Resistance, Microbial - genetics Genetics Horizontal gene transfer Landfill age Landfills Leachates Mobile genetic elements Municipal landfills Municipal solid waste landfill leachates Refuse Disposal Solid Waste Solid waste management Waste Disposal Facilities Water Pollutants, Chemical |
| title | Co-occurrence of mobile genetic elements and antibiotic resistance genes in municipal solid waste landfill leachates: A preliminary insight into the role of landfill age |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T22%3A31%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Co-occurrence%20of%20mobile%20genetic%20elements%20and%20antibiotic%20resistance%20genes%20in%20municipal%20solid%20waste%20landfill%20leachates:%20A%20preliminary%20insight%20into%20the%20role%20of%20landfill%20age&rft.jtitle=Water%20research%20(Oxford)&rft.au=Yu,%20Zhuofeng&rft.date=2016-12-01&rft.volume=106&rft.spage=583&rft.epage=592&rft.pages=583-592&rft.issn=0043-1354&rft.eissn=1879-2448&rft_id=info:doi/10.1016/j.watres.2016.10.042&rft_dat=%3Cproquest_cross%3E1864535944%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1835685940&rft_id=info:pmid/27776307&rft_els_id=S0043135416307953&rfr_iscdi=true |