Graphene oxide induces apoptotic cell death in endothelial cells by activating autophagy via calcium-dependent phosphorylation of c-Jun N-terminal kinases

[Display omitted] Despite the rapid expansion of the biomedical applications of graphene oxide (GO), safety issues related to GO, particularly with regard to its effects on vascular endothelial cells (ECs), have been poorly evaluated. To explore possible GO-mediated vasculature cytotoxicity and dete...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Acta biomaterialia 2016-12, Vol.46, p.191-203
Hauptverfasser:	Lim, Mi-Hee, Jeung, In Cheul, Jeong, Jinyoung, Yoon, Sung-Jin, Lee, Sang-Hyun, Park, Jongjin, Kang, Yu-Seon, Lee, Hansu, Park, Young-Jun, Lee, Hee Gu, Lee, Seon-Jin, Han, Baek Soo, Song, Nam Woong, Lee, Sang Chul, Kim, Jang-Seong, Bae, Kwang-Hee, Min, Jeong-Ki
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylate Kinase - metabolism Apoptosis Apoptosis - drug effects Autophagy Autophagy - drug effects B-cell lymphoma Bcl-2 protein Beclin-1 - metabolism Biocompatibility Biomedical materials c-Jun protein Calcium Calcium (intracellular) Calcium (reticular) Calcium - metabolism Calcium ion Cell death Chelation Cytotoxicity Endoplasmic reticulum Endothelial cell Endothelial cells Endothelium Graphene Graphene oxide Graphite - pharmacology Human Umbilical Vein Endothelial Cells - cytology Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - enzymology Humans Inositol 1,4,5-trisphosphate receptors Intracellular Intracellular Space - metabolism Ions JNK Mitogen-Activated Protein Kinases - metabolism JNK protein Kinases Lymphocytes B Lymphoma Magnesium oxide MAP Kinase Signaling System - drug effects Microscopy, Atomic Force Microtubule-associated protein 1 Models, Biological Nanoparticles Oxides Particle Size Phagocytosis Phosphorylation Phosphorylation - drug effects Proto-Oncogene Proteins c-bcl-2 - metabolism Quantum dots Reactive Oxygen Species - metabolism Toxicity Transcription factors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!