Toxicity mechanism of titanium dioxide and zinc oxide nanoparticles against food pathogens
[Display omitted] •Mechanism of toxicity is analysed.•Toxicity against food pathogens.•ROS, LDH are analysed.•DNA fragmentation is done.•MTT analysis is done. Food preservation is an important field of research. It extends the shelf life of major food products. Our current study is based on food pre...
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| Veröffentlicht in: | Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2016-12, Vol.148, p.600-606 |
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| container_title | Colloids and surfaces, B, Biointerfaces |
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| creator | Venkatasubbu, G. Devanand Baskar, R. Anusuya, T. Seshan, C. Arun Chelliah, Ramachandran |
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•Mechanism of toxicity is analysed.•Toxicity against food pathogens.•ROS, LDH are analysed.•DNA fragmentation is done.•MTT analysis is done.
Food preservation is an important field of research. It extends the shelf life of major food products. Our current study is based on food preservation through TiO2 and ZnO nanoparticles. TiO2 and ZnO are biocompatible nanomaterial. The biocompatibility of the materials were established through toxicity studies on cell lines. Titanium dioxide and Zinc Oxide nanoparticle were synthesized by wet chemical process. They are characterized by X-Ray diffraction and TEM. The antibacterial activities of both the materials were analysed to ensure their effectiveness as food preservative against Salmonella typhi, Klebsiella pneumoniae and Shigella flexneri. The results indicates that TiO2 and ZnO nanoparticle inhibits Salmonella, Klebsiella and Shigella. The mode of action is by the generation of ROS in cases of Salmonella, Klebsiella. Mode of action in Shigella is still unclear. It was also proved that TiO2 and ZnO nanoparticle are biocompatible materials. |
| doi_str_mv | 10.1016/j.colsurfb.2016.09.042 |
| format | Article |
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•Mechanism of toxicity is analysed.•Toxicity against food pathogens.•ROS, LDH are analysed.•DNA fragmentation is done.•MTT analysis is done.
Food preservation is an important field of research. It extends the shelf life of major food products. Our current study is based on food preservation through TiO2 and ZnO nanoparticles. TiO2 and ZnO are biocompatible nanomaterial. The biocompatibility of the materials were established through toxicity studies on cell lines. Titanium dioxide and Zinc Oxide nanoparticle were synthesized by wet chemical process. They are characterized by X-Ray diffraction and TEM. The antibacterial activities of both the materials were analysed to ensure their effectiveness as food preservative against Salmonella typhi, Klebsiella pneumoniae and Shigella flexneri. The results indicates that TiO2 and ZnO nanoparticle inhibits Salmonella, Klebsiella and Shigella. The mode of action is by the generation of ROS in cases of Salmonella, Klebsiella. Mode of action in Shigella is still unclear. It was also proved that TiO2 and ZnO nanoparticle are biocompatible materials.</description><identifier>ISSN: 0927-7765</identifier><identifier>EISSN: 1873-4367</identifier><identifier>DOI: 10.1016/j.colsurfb.2016.09.042</identifier><identifier>PMID: 27694049</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - toxicity ; Biocompatibility ; Biocompatible Materials - chemistry ; Biocompatible Materials - pharmacology ; Biocompatible Materials - toxicity ; Cell Line, Tumor ; Cell Survival - drug effects ; DNA Fragmentation - drug effects ; Food Microbiology ; Food pathogens ; Food Preservatives - chemistry ; Food Preservatives - pharmacology ; Food Preservatives - toxicity ; Foods ; Humans ; Klebsiella ; Klebsiella pneumoniae ; Klebsiella pneumoniae - drug effects ; Klebsiella pneumoniae - genetics ; Klebsiella pneumoniae - growth & development ; Metal Nanoparticles - chemistry ; Metal Nanoparticles - toxicity ; Metal Nanoparticles - ultrastructure ; Microscopy, Electron, Transmission ; Nanoparticles ; Nanostructures - chemistry ; Nanostructures - toxicity ; Nanostructures - ultrastructure ; Reactive Oxygen Species - chemistry ; Reactive Oxygen Species - metabolism ; Salmonella ; Salmonella typhi ; Salmonella typhi - drug effects ; Salmonella typhi - genetics ; Salmonella typhi - growth & development ; Shigella flexneri ; Shigella flexneri - drug effects ; Shigella flexneri - genetics ; Shigella flexneri - growth & development ; Titanium - chemistry ; Titanium dioxide ; Toxicity ; X-Ray Diffraction ; Zinc oxide ; Zinc Oxide - chemistry</subject><ispartof>Colloids and surfaces, B, Biointerfaces, 2016-12, Vol.148, p.600-606</ispartof><rights>2016 Elsevier B.V.</rights><rights>Copyright © 2016 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-58510642fb7ffc798e98745521b34ed8a046387c9e218be81d06e5da10b385a43</citedby><cites>FETCH-LOGICAL-c471t-58510642fb7ffc798e98745521b34ed8a046387c9e218be81d06e5da10b385a43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.colsurfb.2016.09.042$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27694049$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Venkatasubbu, G. Devanand</creatorcontrib><creatorcontrib>Baskar, R.</creatorcontrib><creatorcontrib>Anusuya, T.</creatorcontrib><creatorcontrib>Seshan, C. Arun</creatorcontrib><creatorcontrib>Chelliah, Ramachandran</creatorcontrib><title>Toxicity mechanism of titanium dioxide and zinc oxide nanoparticles against food pathogens</title><title>Colloids and surfaces, B, Biointerfaces</title><addtitle>Colloids Surf B Biointerfaces</addtitle><description>[Display omitted]
•Mechanism of toxicity is analysed.•Toxicity against food pathogens.•ROS, LDH are analysed.•DNA fragmentation is done.•MTT analysis is done.
Food preservation is an important field of research. It extends the shelf life of major food products. Our current study is based on food preservation through TiO2 and ZnO nanoparticles. TiO2 and ZnO are biocompatible nanomaterial. The biocompatibility of the materials were established through toxicity studies on cell lines. Titanium dioxide and Zinc Oxide nanoparticle were synthesized by wet chemical process. They are characterized by X-Ray diffraction and TEM. The antibacterial activities of both the materials were analysed to ensure their effectiveness as food preservative against Salmonella typhi, Klebsiella pneumoniae and Shigella flexneri. The results indicates that TiO2 and ZnO nanoparticle inhibits Salmonella, Klebsiella and Shigella. The mode of action is by the generation of ROS in cases of Salmonella, Klebsiella. Mode of action in Shigella is still unclear. It was also proved that TiO2 and ZnO nanoparticle are biocompatible materials.</description><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - toxicity</subject><subject>Biocompatibility</subject><subject>Biocompatible Materials - chemistry</subject><subject>Biocompatible Materials - pharmacology</subject><subject>Biocompatible Materials - toxicity</subject><subject>Cell Line, Tumor</subject><subject>Cell Survival - drug effects</subject><subject>DNA Fragmentation - drug effects</subject><subject>Food Microbiology</subject><subject>Food pathogens</subject><subject>Food Preservatives - chemistry</subject><subject>Food Preservatives - pharmacology</subject><subject>Food Preservatives - toxicity</subject><subject>Foods</subject><subject>Humans</subject><subject>Klebsiella</subject><subject>Klebsiella pneumoniae</subject><subject>Klebsiella pneumoniae - drug effects</subject><subject>Klebsiella pneumoniae - genetics</subject><subject>Klebsiella pneumoniae - growth & development</subject><subject>Metal Nanoparticles - chemistry</subject><subject>Metal Nanoparticles - toxicity</subject><subject>Metal Nanoparticles - ultrastructure</subject><subject>Microscopy, Electron, Transmission</subject><subject>Nanoparticles</subject><subject>Nanostructures - chemistry</subject><subject>Nanostructures - toxicity</subject><subject>Nanostructures - ultrastructure</subject><subject>Reactive Oxygen Species - chemistry</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Salmonella</subject><subject>Salmonella typhi</subject><subject>Salmonella typhi - drug effects</subject><subject>Salmonella typhi - genetics</subject><subject>Salmonella typhi - growth & development</subject><subject>Shigella flexneri</subject><subject>Shigella flexneri - drug effects</subject><subject>Shigella flexneri - genetics</subject><subject>Shigella flexneri - growth & development</subject><subject>Titanium - chemistry</subject><subject>Titanium dioxide</subject><subject>Toxicity</subject><subject>X-Ray Diffraction</subject><subject>Zinc oxide</subject><subject>Zinc Oxide - chemistry</subject><issn>0927-7765</issn><issn>1873-4367</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1u1TAQhS1ERS8tr1B5ySbBdvy7A1UUkCqxaTfdWI49aX2V2BfbQZSnJ9Vt2cJq5mi-MyPNQeiCkp4SKj_se5_nupZp7Nmme2J6wtkrtKNaDR0fpHqNdsQw1SklxSl6W-ueEMI4VW_QKVPScMLNDt3d5F_Rx_aIF_APLsW64DzhFtvWrwsOcZsHwC4F_Dsmj48yuZQPrrToZ6jY3buYasNTzgEfXHvI95DqOTqZ3Fzh3XM9Q7dXn28uv3bX3798u_x03XmuaOuEFpRIzqZRTZNXRoPRigvB6DhwCNoRLgetvAFG9QiaBiJBBEfJOGjh-HCG3h_3Hkr-sUJtdonVwzy7BHmtlmrJxUCMoP-BcskpZVpsqDyivuRaC0z2UOLiyqOlxD5FYPf2JQL7FIElxm4RbMaL5xvruED4a3v5-QZ8PAKwPeVnhGKrj5A8hFjANxty_NeNP_Cbm4Q</recordid><startdate>20161201</startdate><enddate>20161201</enddate><creator>Venkatasubbu, G. 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Arun ; Chelliah, Ramachandran</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-58510642fb7ffc798e98745521b34ed8a046387c9e218be81d06e5da10b385a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Anti-Bacterial Agents - chemistry</topic><topic>Anti-Bacterial Agents - toxicity</topic><topic>Biocompatibility</topic><topic>Biocompatible Materials - chemistry</topic><topic>Biocompatible Materials - pharmacology</topic><topic>Biocompatible Materials - toxicity</topic><topic>Cell Line, Tumor</topic><topic>Cell Survival - drug effects</topic><topic>DNA Fragmentation - drug effects</topic><topic>Food Microbiology</topic><topic>Food pathogens</topic><topic>Food Preservatives - chemistry</topic><topic>Food Preservatives - pharmacology</topic><topic>Food Preservatives - toxicity</topic><topic>Foods</topic><topic>Humans</topic><topic>Klebsiella</topic><topic>Klebsiella pneumoniae</topic><topic>Klebsiella pneumoniae - drug effects</topic><topic>Klebsiella pneumoniae - genetics</topic><topic>Klebsiella pneumoniae - growth & development</topic><topic>Metal Nanoparticles - chemistry</topic><topic>Metal Nanoparticles - toxicity</topic><topic>Metal Nanoparticles - ultrastructure</topic><topic>Microscopy, Electron, Transmission</topic><topic>Nanoparticles</topic><topic>Nanostructures - chemistry</topic><topic>Nanostructures - toxicity</topic><topic>Nanostructures - ultrastructure</topic><topic>Reactive Oxygen Species - chemistry</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Salmonella</topic><topic>Salmonella typhi</topic><topic>Salmonella typhi - drug effects</topic><topic>Salmonella typhi - genetics</topic><topic>Salmonella typhi - growth & development</topic><topic>Shigella flexneri</topic><topic>Shigella flexneri - drug effects</topic><topic>Shigella flexneri - genetics</topic><topic>Shigella flexneri - growth & development</topic><topic>Titanium - chemistry</topic><topic>Titanium dioxide</topic><topic>Toxicity</topic><topic>X-Ray Diffraction</topic><topic>Zinc oxide</topic><topic>Zinc Oxide - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Venkatasubbu, G. 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Devanand</au><au>Baskar, R.</au><au>Anusuya, T.</au><au>Seshan, C. Arun</au><au>Chelliah, Ramachandran</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Toxicity mechanism of titanium dioxide and zinc oxide nanoparticles against food pathogens</atitle><jtitle>Colloids and surfaces, B, Biointerfaces</jtitle><addtitle>Colloids Surf B Biointerfaces</addtitle><date>2016-12-01</date><risdate>2016</risdate><volume>148</volume><spage>600</spage><epage>606</epage><pages>600-606</pages><issn>0927-7765</issn><eissn>1873-4367</eissn><abstract>[Display omitted]
•Mechanism of toxicity is analysed.•Toxicity against food pathogens.•ROS, LDH are analysed.•DNA fragmentation is done.•MTT analysis is done.
Food preservation is an important field of research. It extends the shelf life of major food products. Our current study is based on food preservation through TiO2 and ZnO nanoparticles. TiO2 and ZnO are biocompatible nanomaterial. The biocompatibility of the materials were established through toxicity studies on cell lines. Titanium dioxide and Zinc Oxide nanoparticle were synthesized by wet chemical process. They are characterized by X-Ray diffraction and TEM. The antibacterial activities of both the materials were analysed to ensure their effectiveness as food preservative against Salmonella typhi, Klebsiella pneumoniae and Shigella flexneri. The results indicates that TiO2 and ZnO nanoparticle inhibits Salmonella, Klebsiella and Shigella. The mode of action is by the generation of ROS in cases of Salmonella, Klebsiella. Mode of action in Shigella is still unclear. It was also proved that TiO2 and ZnO nanoparticle are biocompatible materials.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>27694049</pmid><doi>10.1016/j.colsurfb.2016.09.042</doi><tpages>7</tpages></addata></record> |
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| ispartof | Colloids and surfaces, B, Biointerfaces, 2016-12, Vol.148, p.600-606 |
| issn | 0927-7765 1873-4367 |
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| subjects | Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - toxicity Biocompatibility Biocompatible Materials - chemistry Biocompatible Materials - pharmacology Biocompatible Materials - toxicity Cell Line, Tumor Cell Survival - drug effects DNA Fragmentation - drug effects Food Microbiology Food pathogens Food Preservatives - chemistry Food Preservatives - pharmacology Food Preservatives - toxicity Foods Humans Klebsiella Klebsiella pneumoniae Klebsiella pneumoniae - drug effects Klebsiella pneumoniae - genetics Klebsiella pneumoniae - growth & development Metal Nanoparticles - chemistry Metal Nanoparticles - toxicity Metal Nanoparticles - ultrastructure Microscopy, Electron, Transmission Nanoparticles Nanostructures - chemistry Nanostructures - toxicity Nanostructures - ultrastructure Reactive Oxygen Species - chemistry Reactive Oxygen Species - metabolism Salmonella Salmonella typhi Salmonella typhi - drug effects Salmonella typhi - genetics Salmonella typhi - growth & development Shigella flexneri Shigella flexneri - drug effects Shigella flexneri - genetics Shigella flexneri - growth & development Titanium - chemistry Titanium dioxide Toxicity X-Ray Diffraction Zinc oxide Zinc Oxide - chemistry |
| title | Toxicity mechanism of titanium dioxide and zinc oxide nanoparticles against food pathogens |
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