Histamine stimulates production of osteoclast differentiation factor/receptor activator of nuclear factor-κB ligand by osteoblasts
Histamine H 1, H 2 , and H 3 receptors are expressed by osteoblastic MC3T3-E1 (E1) cells derived from mouse calvaria. Expression of the osteoclast differentiation factor (ODF)/receptor activator of nuclear factor-κB ligand (RANKL) transcript was induced in E1 cells and bone marrow stromal cells (ST2...
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| Veröffentlicht in: | Biochemical and biophysical research communications 2002-10, Vol.298 (2), p.240-246 |
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| container_title | Biochemical and biophysical research communications |
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| creator | Deyama, Yoshiaki Kikuiri, Takashi Ohnishi, Gen-ichi Feng, Yi-Gang Takeyama, Sadaaki Hatta, Mitsutoki Yoshimura, Yoshitaka Suzuki, Kuniaki |
| description | Histamine
H
1,
H
2
, and H
3 receptors are expressed by osteoblastic MC3T3-E1 (E1) cells derived from mouse calvaria. Expression of the osteoclast differentiation factor (ODF)/receptor activator of nuclear factor-κB ligand (RANKL) transcript was induced in E1 cells and bone marrow stromal cells (ST2). Histamine markedly increased the steady-state level of ODF/RANKL mRNA in a dose-dependent manner. The effect of histamine on expression of ODF/RANKL mRNA by E1 cells was transient, with a peak at 6
h. Western blot analysis revealed that histamine increased production of ODF/RANKL protein by E1 cells at 12
h. In cocultures of E1 cells and mouse bone marrow cells, histamine stimulated osteoclastogenesis in the presence of 1,25-dihydroxyvitamin D
3 and this effect was blocked by preincubation with neutralizing antibody against ODF/RANKL. These results suggest that histamine regulates osteoclastogenesis, at least in part, through induction of ODF/RANKL expression by osteoblasts and bone marrow stromal cells. |
| doi_str_mv | 10.1016/S0006-291X(02)02440-3 |
| format | Article |
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H
1,
H
2
, and H
3 receptors are expressed by osteoblastic MC3T3-E1 (E1) cells derived from mouse calvaria. Expression of the osteoclast differentiation factor (ODF)/receptor activator of nuclear factor-κB ligand (RANKL) transcript was induced in E1 cells and bone marrow stromal cells (ST2). Histamine markedly increased the steady-state level of ODF/RANKL mRNA in a dose-dependent manner. The effect of histamine on expression of ODF/RANKL mRNA by E1 cells was transient, with a peak at 6
h. Western blot analysis revealed that histamine increased production of ODF/RANKL protein by E1 cells at 12
h. In cocultures of E1 cells and mouse bone marrow cells, histamine stimulated osteoclastogenesis in the presence of 1,25-dihydroxyvitamin D
3 and this effect was blocked by preincubation with neutralizing antibody against ODF/RANKL. These results suggest that histamine regulates osteoclastogenesis, at least in part, through induction of ODF/RANKL expression by osteoblasts and bone marrow stromal cells.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/S0006-291X(02)02440-3</identifier><language>eng</language><publisher>Elsevier Inc</publisher><subject>Histamine ; Histamine receptor ; Osteoblast ; Osteoclast ; Osteoclast differentiation factor/receptor activator of nuclear factor-κB ligand (ODF/RANKL) ; Stromal cell</subject><ispartof>Biochemical and biophysical research communications, 2002-10, Vol.298 (2), p.240-246</ispartof><rights>2002 Elsevier Science (USA)</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c338t-fd752df9b3a5d5f3080ee1bed98218ef93961c69e6d360a2dee060837f5739043</citedby><cites>FETCH-LOGICAL-c338t-fd752df9b3a5d5f3080ee1bed98218ef93961c69e6d360a2dee060837f5739043</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006291X02024403$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids></links><search><creatorcontrib>Deyama, Yoshiaki</creatorcontrib><creatorcontrib>Kikuiri, Takashi</creatorcontrib><creatorcontrib>Ohnishi, Gen-ichi</creatorcontrib><creatorcontrib>Feng, Yi-Gang</creatorcontrib><creatorcontrib>Takeyama, Sadaaki</creatorcontrib><creatorcontrib>Hatta, Mitsutoki</creatorcontrib><creatorcontrib>Yoshimura, Yoshitaka</creatorcontrib><creatorcontrib>Suzuki, Kuniaki</creatorcontrib><title>Histamine stimulates production of osteoclast differentiation factor/receptor activator of nuclear factor-κB ligand by osteoblasts</title><title>Biochemical and biophysical research communications</title><description>Histamine
H
1,
H
2
, and H
3 receptors are expressed by osteoblastic MC3T3-E1 (E1) cells derived from mouse calvaria. Expression of the osteoclast differentiation factor (ODF)/receptor activator of nuclear factor-κB ligand (RANKL) transcript was induced in E1 cells and bone marrow stromal cells (ST2). Histamine markedly increased the steady-state level of ODF/RANKL mRNA in a dose-dependent manner. The effect of histamine on expression of ODF/RANKL mRNA by E1 cells was transient, with a peak at 6
h. Western blot analysis revealed that histamine increased production of ODF/RANKL protein by E1 cells at 12
h. In cocultures of E1 cells and mouse bone marrow cells, histamine stimulated osteoclastogenesis in the presence of 1,25-dihydroxyvitamin D
3 and this effect was blocked by preincubation with neutralizing antibody against ODF/RANKL. These results suggest that histamine regulates osteoclastogenesis, at least in part, through induction of ODF/RANKL expression by osteoblasts and bone marrow stromal cells.</description><subject>Histamine</subject><subject>Histamine receptor</subject><subject>Osteoblast</subject><subject>Osteoclast</subject><subject>Osteoclast differentiation factor/receptor activator of nuclear factor-κB ligand (ODF/RANKL)</subject><subject>Stromal cell</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNqFkM1KAzEUhYMoWH8eQZiV6GL0JplJJyvR4h8ILlRwF9LkRiLTSU0yha59Kx_CZ3LailtX917uOQfOR8gRhTMKVJw_AYAomaSvJ8BOgVUVlHyLjChIKBmFapuM_iS7ZC-ldwBKKyFH5PPOp6xnvsMiZT_rW50xFfMYbG-yD10RXBFSxmBanXJhvXMYscter79OmxzieUSD82EphtMv9GobfF1vWtTxV1R-f10VrX_TnS2my03odBWaDsiO023Cw9-5T15urp8nd-XD4-395PKhNJw3uXR2XDPr5JTr2taOQwOIdIpWNow26CSXghohUVguQDOLCAIaPnb1mEuo-D453uQO9T56TFnNfDLYtrrD0CdFG1GxMaeDsN4ITQwpRXRqHv1Mx6WioFbI1Rq5WvFUwNQaueKD72Ljw6HFwmNUyXjsDFo_EMrKBv9Pwg8iDo1u</recordid><startdate>20021025</startdate><enddate>20021025</enddate><creator>Deyama, Yoshiaki</creator><creator>Kikuiri, Takashi</creator><creator>Ohnishi, Gen-ichi</creator><creator>Feng, Yi-Gang</creator><creator>Takeyama, Sadaaki</creator><creator>Hatta, Mitsutoki</creator><creator>Yoshimura, Yoshitaka</creator><creator>Suzuki, Kuniaki</creator><general>Elsevier Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope></search><sort><creationdate>20021025</creationdate><title>Histamine stimulates production of osteoclast differentiation factor/receptor activator of nuclear factor-κB ligand by osteoblasts</title><author>Deyama, Yoshiaki ; Kikuiri, Takashi ; Ohnishi, Gen-ichi ; Feng, Yi-Gang ; Takeyama, Sadaaki ; Hatta, Mitsutoki ; Yoshimura, Yoshitaka ; Suzuki, Kuniaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c338t-fd752df9b3a5d5f3080ee1bed98218ef93961c69e6d360a2dee060837f5739043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Histamine</topic><topic>Histamine receptor</topic><topic>Osteoblast</topic><topic>Osteoclast</topic><topic>Osteoclast differentiation factor/receptor activator of nuclear factor-κB ligand (ODF/RANKL)</topic><topic>Stromal cell</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Deyama, Yoshiaki</creatorcontrib><creatorcontrib>Kikuiri, Takashi</creatorcontrib><creatorcontrib>Ohnishi, Gen-ichi</creatorcontrib><creatorcontrib>Feng, Yi-Gang</creatorcontrib><creatorcontrib>Takeyama, Sadaaki</creatorcontrib><creatorcontrib>Hatta, Mitsutoki</creatorcontrib><creatorcontrib>Yoshimura, Yoshitaka</creatorcontrib><creatorcontrib>Suzuki, Kuniaki</creatorcontrib><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Deyama, Yoshiaki</au><au>Kikuiri, Takashi</au><au>Ohnishi, Gen-ichi</au><au>Feng, Yi-Gang</au><au>Takeyama, Sadaaki</au><au>Hatta, Mitsutoki</au><au>Yoshimura, Yoshitaka</au><au>Suzuki, Kuniaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histamine stimulates production of osteoclast differentiation factor/receptor activator of nuclear factor-κB ligand by osteoblasts</atitle><jtitle>Biochemical and biophysical research communications</jtitle><date>2002-10-25</date><risdate>2002</risdate><volume>298</volume><issue>2</issue><spage>240</spage><epage>246</epage><pages>240-246</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>Histamine
H
1,
H
2
, and H
3 receptors are expressed by osteoblastic MC3T3-E1 (E1) cells derived from mouse calvaria. Expression of the osteoclast differentiation factor (ODF)/receptor activator of nuclear factor-κB ligand (RANKL) transcript was induced in E1 cells and bone marrow stromal cells (ST2). Histamine markedly increased the steady-state level of ODF/RANKL mRNA in a dose-dependent manner. The effect of histamine on expression of ODF/RANKL mRNA by E1 cells was transient, with a peak at 6
h. Western blot analysis revealed that histamine increased production of ODF/RANKL protein by E1 cells at 12
h. In cocultures of E1 cells and mouse bone marrow cells, histamine stimulated osteoclastogenesis in the presence of 1,25-dihydroxyvitamin D
3 and this effect was blocked by preincubation with neutralizing antibody against ODF/RANKL. These results suggest that histamine regulates osteoclastogenesis, at least in part, through induction of ODF/RANKL expression by osteoblasts and bone marrow stromal cells.</abstract><pub>Elsevier Inc</pub><doi>10.1016/S0006-291X(02)02440-3</doi><tpages>7</tpages></addata></record> |
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| ispartof | Biochemical and biophysical research communications, 2002-10, Vol.298 (2), p.240-246 |
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| subjects | Histamine Histamine receptor Osteoblast Osteoclast Osteoclast differentiation factor/receptor activator of nuclear factor-κB ligand (ODF/RANKL) Stromal cell |
| title | Histamine stimulates production of osteoclast differentiation factor/receptor activator of nuclear factor-κB ligand by osteoblasts |
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