Effects of serotonin-3 receptor antagonists on the intracranial self-administration of ethanol within the ventral tegmental area of Wistar rats
Previous work from our laboratory indicated that Wistar rats will self-administer ethanol (EtOH) directly into the posterior ventral tegmental area (VTA) and that 5-HT(3) antagonists will inhibit EtOH-stimulated somatodendritic release of dopamine within the VTA. The objective of this study was to u...
Gespeichert in:
| Veröffentlicht in: | Psychopharmacologia 2003, Vol.165 (3), p.252-259 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 259 |
|---|---|
| container_issue | 3 |
| container_start_page | 252 |
| container_title | Psychopharmacologia |
| container_volume | 165 |
| creator | RODD-HENRICKS, Zachary A MCKINZIE, David L MELENDEZ, Roberto I BERRY, Nada MURPHY, James M MCBRIDE, William J |
| description | Previous work from our laboratory indicated that Wistar rats will self-administer ethanol (EtOH) directly into the posterior ventral tegmental area (VTA) and that 5-HT(3) antagonists will inhibit EtOH-stimulated somatodendritic release of dopamine within the VTA.
The objective of this study was to use the intracranial self-administration procedure to determine the involvement of 5-HT(3)receptors in mediating the reinforcing effects of EtOH within the VTA, and to increase our understanding of central nervous system mechanisms involved in the rewarding effects of EtOH.
Adult female Wistar rats were stereotaxically implanted with guide cannulae aimed at the posterior VTA. After 1 week, rats were placed into standard two-lever experimental chambers for a total of seven sessions (4-h sessions separated by 48 h) and allowed to self-administer vehicle alone, a 5-HT(3) antagonist alone, 200 mg% EtOH alone, or combinations of 200 mg% EtOH with different concentrations of a 5-HT(3) antagonist ( n=6-9 per group).
Throughout all seven sessions, Wistar rats self-infused more 200 mg% ETOH (25+/-5 infusions) than vehicle (5+/-4 infusions) or 5-HT(3) antagonist (6+/-4 infusions) ( P |
| doi_str_mv | 10.1007/s00213-002-1300-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_18641087</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>723532751</sourcerecordid><originalsourceid>FETCH-LOGICAL-c385t-73d2566809726666583336210ee2362a2ca820ee42ee4f9ffc62e129ae2bf2273</originalsourceid><addsrcrecordid>eNpdkV1rFTEQhoNY7LH6A7yRRdC71GSyH9lLKfUDCt5UvAzTnElPym72mOQo_RX-ZWc5BwoOZGYSnndI8grxRqtLrdTwsSgF2kjOUhulJDwTG90akKAGeC42Shkjje7suXhZyoPiaG37QpxraNuhV91G_L0OgXwtzRKaQnmpS4pJmiaTp31dcoOp4j0flpVJTd1RE1PN6DOmiBOLpiBxO8cVyVgjQzyL6g7TMjV_Yt3Fo-w3rbqpqXQ_c8sdZsIV_slSzA2ryytxFnAq9PpUL8SPz9e3V1_lzfcv364-3UhvbFflYLbQ9b1V4wA9R2eNMT1oRQRcETxa4E0LvMIYgu-BNIxIcBcABnMhPhzn7vPy60ClujkWT9OEiZZDcdr2rVZ2Bd_9Bz4sh5z4bg60HS2MvWVIHyGfl1IyBbfPccb86LRyq1XuaJXj7FarHLDm7Wnw4W6m7ZPi5A0D708AFo9T4A_3sTxxbTeMIz_lH9GZnQM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>218982968</pqid></control><display><type>article</type><title>Effects of serotonin-3 receptor antagonists on the intracranial self-administration of ethanol within the ventral tegmental area of Wistar rats</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>RODD-HENRICKS, Zachary A ; MCKINZIE, David L ; MELENDEZ, Roberto I ; BERRY, Nada ; MURPHY, James M ; MCBRIDE, William J</creator><creatorcontrib>RODD-HENRICKS, Zachary A ; MCKINZIE, David L ; MELENDEZ, Roberto I ; BERRY, Nada ; MURPHY, James M ; MCBRIDE, William J</creatorcontrib><description>Previous work from our laboratory indicated that Wistar rats will self-administer ethanol (EtOH) directly into the posterior ventral tegmental area (VTA) and that 5-HT(3) antagonists will inhibit EtOH-stimulated somatodendritic release of dopamine within the VTA.
The objective of this study was to use the intracranial self-administration procedure to determine the involvement of 5-HT(3)receptors in mediating the reinforcing effects of EtOH within the VTA, and to increase our understanding of central nervous system mechanisms involved in the rewarding effects of EtOH.
Adult female Wistar rats were stereotaxically implanted with guide cannulae aimed at the posterior VTA. After 1 week, rats were placed into standard two-lever experimental chambers for a total of seven sessions (4-h sessions separated by 48 h) and allowed to self-administer vehicle alone, a 5-HT(3) antagonist alone, 200 mg% EtOH alone, or combinations of 200 mg% EtOH with different concentrations of a 5-HT(3) antagonist ( n=6-9 per group).
Throughout all seven sessions, Wistar rats self-infused more 200 mg% ETOH (25+/-5 infusions) than vehicle (5+/-4 infusions) or 5-HT(3) antagonist (6+/-4 infusions) ( P<0.05), and responded significantly more ( P<0.05) on the active than inactive lever (e.g., 50+/-12 vs 12+/-8 responses in session 1). Co-administration of 50 micro M or 100 micro M ICS 205,930 with 200 mg% EtOH completely prevented the acquisition and maintenance of EtOH self-infusion into the posterior VTA. Similarly, co-administration of either 25-100 micro M LY-278-584 or 10-100 micro M zacopride with 200 mg% EtOH completely blocked EtOH-maintained intracranial self-administration behavior.
The results of this study suggest that the reinforcing effects of EtOH within the posterior VTA of Wistar rats require activation of local 5-HT(3) receptors.</description><identifier>ISSN: 0033-3158</identifier><identifier>EISSN: 1432-2072</identifier><identifier>DOI: 10.1007/s00213-002-1300-2</identifier><identifier>PMID: 12447605</identifier><identifier>CODEN: PSYPAG</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Alcoholism and acute alcohol poisoning ; Animals ; Benzamides - pharmacology ; Biological and medical sciences ; Bridged Bicyclo Compounds, Heterocyclic - pharmacology ; Central Nervous System Depressants - administration & dosage ; Central Nervous System Depressants - pharmacology ; Drug Interactions ; Ethanol - administration & dosage ; Ethanol - pharmacology ; Female ; Indazoles - pharmacology ; Indoles - pharmacology ; Medical sciences ; Rats ; Rats, Wistar ; Receptors, Serotonin - drug effects ; Receptors, Serotonin - physiology ; Receptors, Serotonin, 5-HT3 ; Self Administration ; Serotonin Antagonists - pharmacology ; Stereoisomerism ; Toxicology ; Tropanes - pharmacology ; Ventral Tegmental Area - drug effects ; Ventral Tegmental Area - physiology</subject><ispartof>Psychopharmacologia, 2003, Vol.165 (3), p.252-259</ispartof><rights>2003 INIST-CNRS</rights><rights>Copyright Springer-Verlag 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-73d2566809726666583336210ee2362a2ca820ee42ee4f9ffc62e129ae2bf2273</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4009,27902,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14579927$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12447605$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>RODD-HENRICKS, Zachary A</creatorcontrib><creatorcontrib>MCKINZIE, David L</creatorcontrib><creatorcontrib>MELENDEZ, Roberto I</creatorcontrib><creatorcontrib>BERRY, Nada</creatorcontrib><creatorcontrib>MURPHY, James M</creatorcontrib><creatorcontrib>MCBRIDE, William J</creatorcontrib><title>Effects of serotonin-3 receptor antagonists on the intracranial self-administration of ethanol within the ventral tegmental area of Wistar rats</title><title>Psychopharmacologia</title><addtitle>Psychopharmacology (Berl)</addtitle><description>Previous work from our laboratory indicated that Wistar rats will self-administer ethanol (EtOH) directly into the posterior ventral tegmental area (VTA) and that 5-HT(3) antagonists will inhibit EtOH-stimulated somatodendritic release of dopamine within the VTA.
The objective of this study was to use the intracranial self-administration procedure to determine the involvement of 5-HT(3)receptors in mediating the reinforcing effects of EtOH within the VTA, and to increase our understanding of central nervous system mechanisms involved in the rewarding effects of EtOH.
Adult female Wistar rats were stereotaxically implanted with guide cannulae aimed at the posterior VTA. After 1 week, rats were placed into standard two-lever experimental chambers for a total of seven sessions (4-h sessions separated by 48 h) and allowed to self-administer vehicle alone, a 5-HT(3) antagonist alone, 200 mg% EtOH alone, or combinations of 200 mg% EtOH with different concentrations of a 5-HT(3) antagonist ( n=6-9 per group).
Throughout all seven sessions, Wistar rats self-infused more 200 mg% ETOH (25+/-5 infusions) than vehicle (5+/-4 infusions) or 5-HT(3) antagonist (6+/-4 infusions) ( P<0.05), and responded significantly more ( P<0.05) on the active than inactive lever (e.g., 50+/-12 vs 12+/-8 responses in session 1). Co-administration of 50 micro M or 100 micro M ICS 205,930 with 200 mg% EtOH completely prevented the acquisition and maintenance of EtOH self-infusion into the posterior VTA. Similarly, co-administration of either 25-100 micro M LY-278-584 or 10-100 micro M zacopride with 200 mg% EtOH completely blocked EtOH-maintained intracranial self-administration behavior.
The results of this study suggest that the reinforcing effects of EtOH within the posterior VTA of Wistar rats require activation of local 5-HT(3) receptors.</description><subject>Alcoholism and acute alcohol poisoning</subject><subject>Animals</subject><subject>Benzamides - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Bridged Bicyclo Compounds, Heterocyclic - pharmacology</subject><subject>Central Nervous System Depressants - administration & dosage</subject><subject>Central Nervous System Depressants - pharmacology</subject><subject>Drug Interactions</subject><subject>Ethanol - administration & dosage</subject><subject>Ethanol - pharmacology</subject><subject>Female</subject><subject>Indazoles - pharmacology</subject><subject>Indoles - pharmacology</subject><subject>Medical sciences</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Receptors, Serotonin - drug effects</subject><subject>Receptors, Serotonin - physiology</subject><subject>Receptors, Serotonin, 5-HT3</subject><subject>Self Administration</subject><subject>Serotonin Antagonists - pharmacology</subject><subject>Stereoisomerism</subject><subject>Toxicology</subject><subject>Tropanes - pharmacology</subject><subject>Ventral Tegmental Area - drug effects</subject><subject>Ventral Tegmental Area - physiology</subject><issn>0033-3158</issn><issn>1432-2072</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkV1rFTEQhoNY7LH6A7yRRdC71GSyH9lLKfUDCt5UvAzTnElPym72mOQo_RX-ZWc5BwoOZGYSnndI8grxRqtLrdTwsSgF2kjOUhulJDwTG90akKAGeC42Shkjje7suXhZyoPiaG37QpxraNuhV91G_L0OgXwtzRKaQnmpS4pJmiaTp31dcoOp4j0flpVJTd1RE1PN6DOmiBOLpiBxO8cVyVgjQzyL6g7TMjV_Yt3Fo-w3rbqpqXQ_c8sdZsIV_slSzA2ryytxFnAq9PpUL8SPz9e3V1_lzfcv364-3UhvbFflYLbQ9b1V4wA9R2eNMT1oRQRcETxa4E0LvMIYgu-BNIxIcBcABnMhPhzn7vPy60ClujkWT9OEiZZDcdr2rVZ2Bd_9Bz4sh5z4bg60HS2MvWVIHyGfl1IyBbfPccb86LRyq1XuaJXj7FarHLDm7Wnw4W6m7ZPi5A0D708AFo9T4A_3sTxxbTeMIz_lH9GZnQM</recordid><startdate>2003</startdate><enddate>2003</enddate><creator>RODD-HENRICKS, Zachary A</creator><creator>MCKINZIE, David L</creator><creator>MELENDEZ, Roberto I</creator><creator>BERRY, Nada</creator><creator>MURPHY, James M</creator><creator>MCBRIDE, William J</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QR</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>2003</creationdate><title>Effects of serotonin-3 receptor antagonists on the intracranial self-administration of ethanol within the ventral tegmental area of Wistar rats</title><author>RODD-HENRICKS, Zachary A ; MCKINZIE, David L ; MELENDEZ, Roberto I ; BERRY, Nada ; MURPHY, James M ; MCBRIDE, William J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-73d2566809726666583336210ee2362a2ca820ee42ee4f9ffc62e129ae2bf2273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Alcoholism and acute alcohol poisoning</topic><topic>Animals</topic><topic>Benzamides - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Bridged Bicyclo Compounds, Heterocyclic - pharmacology</topic><topic>Central Nervous System Depressants - administration & dosage</topic><topic>Central Nervous System Depressants - pharmacology</topic><topic>Drug Interactions</topic><topic>Ethanol - administration & dosage</topic><topic>Ethanol - pharmacology</topic><topic>Female</topic><topic>Indazoles - pharmacology</topic><topic>Indoles - pharmacology</topic><topic>Medical sciences</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Receptors, Serotonin - drug effects</topic><topic>Receptors, Serotonin - physiology</topic><topic>Receptors, Serotonin, 5-HT3</topic><topic>Self Administration</topic><topic>Serotonin Antagonists - pharmacology</topic><topic>Stereoisomerism</topic><topic>Toxicology</topic><topic>Tropanes - pharmacology</topic><topic>Ventral Tegmental Area - drug effects</topic><topic>Ventral Tegmental Area - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>RODD-HENRICKS, Zachary A</creatorcontrib><creatorcontrib>MCKINZIE, David L</creatorcontrib><creatorcontrib>MELENDEZ, Roberto I</creatorcontrib><creatorcontrib>BERRY, Nada</creatorcontrib><creatorcontrib>MURPHY, James M</creatorcontrib><creatorcontrib>MCBRIDE, William J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>Psychopharmacologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>RODD-HENRICKS, Zachary A</au><au>MCKINZIE, David L</au><au>MELENDEZ, Roberto I</au><au>BERRY, Nada</au><au>MURPHY, James M</au><au>MCBRIDE, William J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of serotonin-3 receptor antagonists on the intracranial self-administration of ethanol within the ventral tegmental area of Wistar rats</atitle><jtitle>Psychopharmacologia</jtitle><addtitle>Psychopharmacology (Berl)</addtitle><date>2003</date><risdate>2003</risdate><volume>165</volume><issue>3</issue><spage>252</spage><epage>259</epage><pages>252-259</pages><issn>0033-3158</issn><eissn>1432-2072</eissn><coden>PSYPAG</coden><abstract>Previous work from our laboratory indicated that Wistar rats will self-administer ethanol (EtOH) directly into the posterior ventral tegmental area (VTA) and that 5-HT(3) antagonists will inhibit EtOH-stimulated somatodendritic release of dopamine within the VTA.
The objective of this study was to use the intracranial self-administration procedure to determine the involvement of 5-HT(3)receptors in mediating the reinforcing effects of EtOH within the VTA, and to increase our understanding of central nervous system mechanisms involved in the rewarding effects of EtOH.
Adult female Wistar rats were stereotaxically implanted with guide cannulae aimed at the posterior VTA. After 1 week, rats were placed into standard two-lever experimental chambers for a total of seven sessions (4-h sessions separated by 48 h) and allowed to self-administer vehicle alone, a 5-HT(3) antagonist alone, 200 mg% EtOH alone, or combinations of 200 mg% EtOH with different concentrations of a 5-HT(3) antagonist ( n=6-9 per group).
Throughout all seven sessions, Wistar rats self-infused more 200 mg% ETOH (25+/-5 infusions) than vehicle (5+/-4 infusions) or 5-HT(3) antagonist (6+/-4 infusions) ( P<0.05), and responded significantly more ( P<0.05) on the active than inactive lever (e.g., 50+/-12 vs 12+/-8 responses in session 1). Co-administration of 50 micro M or 100 micro M ICS 205,930 with 200 mg% EtOH completely prevented the acquisition and maintenance of EtOH self-infusion into the posterior VTA. Similarly, co-administration of either 25-100 micro M LY-278-584 or 10-100 micro M zacopride with 200 mg% EtOH completely blocked EtOH-maintained intracranial self-administration behavior.
The results of this study suggest that the reinforcing effects of EtOH within the posterior VTA of Wistar rats require activation of local 5-HT(3) receptors.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>12447605</pmid><doi>10.1007/s00213-002-1300-2</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0033-3158 |
| ispartof | Psychopharmacologia, 2003, Vol.165 (3), p.252-259 |
| issn | 0033-3158 1432-2072 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_18641087 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Alcoholism and acute alcohol poisoning Animals Benzamides - pharmacology Biological and medical sciences Bridged Bicyclo Compounds, Heterocyclic - pharmacology Central Nervous System Depressants - administration & dosage Central Nervous System Depressants - pharmacology Drug Interactions Ethanol - administration & dosage Ethanol - pharmacology Female Indazoles - pharmacology Indoles - pharmacology Medical sciences Rats Rats, Wistar Receptors, Serotonin - drug effects Receptors, Serotonin - physiology Receptors, Serotonin, 5-HT3 Self Administration Serotonin Antagonists - pharmacology Stereoisomerism Toxicology Tropanes - pharmacology Ventral Tegmental Area - drug effects Ventral Tegmental Area - physiology |
| title | Effects of serotonin-3 receptor antagonists on the intracranial self-administration of ethanol within the ventral tegmental area of Wistar rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-21T15%3A11%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20serotonin-3%20receptor%20antagonists%20on%20the%20intracranial%20self-administration%20of%20ethanol%20within%20the%20ventral%20tegmental%20area%20of%20Wistar%20rats&rft.jtitle=Psychopharmacologia&rft.au=RODD-HENRICKS,%20Zachary%20A&rft.date=2003&rft.volume=165&rft.issue=3&rft.spage=252&rft.epage=259&rft.pages=252-259&rft.issn=0033-3158&rft.eissn=1432-2072&rft.coden=PSYPAG&rft_id=info:doi/10.1007/s00213-002-1300-2&rft_dat=%3Cproquest_cross%3E723532751%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=218982968&rft_id=info:pmid/12447605&rfr_iscdi=true |