Alterations in conjunctival bacteria and antimicrobial susceptibility during topical administration of ofloxacin after cataract surgery in dogs
OBJECTIVE To evaluate changes in conjunctival bacteria and antimicrobial susceptibility of bacteria after cataract surgery in dogs. ANIMALS 16 client-owned dogs. PROCEDURES Samples for aerobic and anaerobic culture were obtained from the conjunctival fornices of both eyes of dogs 24 hours before (we...
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Veröffentlicht in: | American journal of veterinary research 2017-02, Vol.78 (2), p.207-214 |
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creator | Sandmeyer, Lynne S Bauer, Bianca S Mohaghegh Poor, Seyed Mohammad Feng, Cindy Xin Chirino-Trejo, Manuel |
description | OBJECTIVE To evaluate changes in conjunctival bacteria and antimicrobial susceptibility of bacteria after cataract surgery in dogs. ANIMALS 16 client-owned dogs. PROCEDURES Samples for aerobic and anaerobic culture were obtained from the conjunctival fornices of both eyes of dogs 24 hours before (week 0) and 1, 3, and 6 weeks after cataract surgery. Topical administration of ofloxacin (every 6 hours) was initiated 12 hours before surgery and continued for 3 weeks. In vitro antimicrobial susceptibility was determined by Kirby-Bauer disk diffusion and a commercially available test for ofloxacin. RESULTS Frequency of positive culture results was significantly higher at week 6 than at weeks 0 and 1. Bacterial load was more likely to be moderate or high at weeks 3 and 6 than at weeks 0 and 1. The most frequently cultured organism was Staphylococcus pseudintermedius (21/78 [26.9%]), followed by coagulase-negative Staphylococcus spp (19/78 [24.4%]). Staphylococcus pseudintermedius was the organism most frequently cultured at weeks 0 (5/12), 1 (4/12), and 6 (8/19), whereas frequency of this organism was lowest at week 3 (1/20). In contrast, coagulase-negative Staphylococcus spp were the most frequently cultured organisms at week 3 (10/20). There was a significant increase in the proportion of organisms resistant to ofloxacin at week 3, compared with the proportion at week 0. CONCLUSIONS AND CLINICAL RELEVANCE The number of bacterial organisms increased and the population of conjunctival bacteria was altered and had a higher proportion resistant to ofloxacin during the 6 weeks after cataract surgery for dogs treated by use of this protocol. |
doi_str_mv | 10.2460/ajvr.78.2.207 |
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ANIMALS 16 client-owned dogs. PROCEDURES Samples for aerobic and anaerobic culture were obtained from the conjunctival fornices of both eyes of dogs 24 hours before (week 0) and 1, 3, and 6 weeks after cataract surgery. Topical administration of ofloxacin (every 6 hours) was initiated 12 hours before surgery and continued for 3 weeks. In vitro antimicrobial susceptibility was determined by Kirby-Bauer disk diffusion and a commercially available test for ofloxacin. RESULTS Frequency of positive culture results was significantly higher at week 6 than at weeks 0 and 1. Bacterial load was more likely to be moderate or high at weeks 3 and 6 than at weeks 0 and 1. The most frequently cultured organism was Staphylococcus pseudintermedius (21/78 [26.9%]), followed by coagulase-negative Staphylococcus spp (19/78 [24.4%]). Staphylococcus pseudintermedius was the organism most frequently cultured at weeks 0 (5/12), 1 (4/12), and 6 (8/19), whereas frequency of this organism was lowest at week 3 (1/20). In contrast, coagulase-negative Staphylococcus spp were the most frequently cultured organisms at week 3 (10/20). There was a significant increase in the proportion of organisms resistant to ofloxacin at week 3, compared with the proportion at week 0. CONCLUSIONS AND CLINICAL RELEVANCE The number of bacterial organisms increased and the population of conjunctival bacteria was altered and had a higher proportion resistant to ofloxacin during the 6 weeks after cataract surgery for dogs treated by use of this protocol.</description><identifier>ISSN: 0002-9645</identifier><identifier>EISSN: 1943-5681</identifier><identifier>DOI: 10.2460/ajvr.78.2.207</identifier><identifier>PMID: 28140645</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Anti-Infective Agents - pharmacology ; Anti-Infective Agents - therapeutic use ; Cataract - veterinary ; Cataract Extraction - veterinary ; Conjunctiva - microbiology ; Dog Diseases - surgery ; Dogs ; Drug Resistance, Bacterial ; Microbial Sensitivity Tests ; Ofloxacin - administration & dosage ; Ofloxacin - therapeutic use ; Ophthalmic Solutions - pharmacology ; Ophthalmic Solutions - therapeutic use ; Staphylococcus - drug effects</subject><ispartof>American journal of veterinary research, 2017-02, Vol.78 (2), p.207-214</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c293t-25f2727127fa05d3b222c58119f5db2411d41eede51698782d06810226ed488d3</citedby><cites>FETCH-LOGICAL-c293t-25f2727127fa05d3b222c58119f5db2411d41eede51698782d06810226ed488d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28140645$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sandmeyer, Lynne S</creatorcontrib><creatorcontrib>Bauer, Bianca S</creatorcontrib><creatorcontrib>Mohaghegh Poor, Seyed Mohammad</creatorcontrib><creatorcontrib>Feng, Cindy Xin</creatorcontrib><creatorcontrib>Chirino-Trejo, Manuel</creatorcontrib><title>Alterations in conjunctival bacteria and antimicrobial susceptibility during topical administration of ofloxacin after cataract surgery in dogs</title><title>American journal of veterinary research</title><addtitle>Am J Vet Res</addtitle><description>OBJECTIVE To evaluate changes in conjunctival bacteria and antimicrobial susceptibility of bacteria after cataract surgery in dogs. ANIMALS 16 client-owned dogs. PROCEDURES Samples for aerobic and anaerobic culture were obtained from the conjunctival fornices of both eyes of dogs 24 hours before (week 0) and 1, 3, and 6 weeks after cataract surgery. Topical administration of ofloxacin (every 6 hours) was initiated 12 hours before surgery and continued for 3 weeks. In vitro antimicrobial susceptibility was determined by Kirby-Bauer disk diffusion and a commercially available test for ofloxacin. RESULTS Frequency of positive culture results was significantly higher at week 6 than at weeks 0 and 1. Bacterial load was more likely to be moderate or high at weeks 3 and 6 than at weeks 0 and 1. The most frequently cultured organism was Staphylococcus pseudintermedius (21/78 [26.9%]), followed by coagulase-negative Staphylococcus spp (19/78 [24.4%]). Staphylococcus pseudintermedius was the organism most frequently cultured at weeks 0 (5/12), 1 (4/12), and 6 (8/19), whereas frequency of this organism was lowest at week 3 (1/20). In contrast, coagulase-negative Staphylococcus spp were the most frequently cultured organisms at week 3 (10/20). There was a significant increase in the proportion of organisms resistant to ofloxacin at week 3, compared with the proportion at week 0. CONCLUSIONS AND CLINICAL RELEVANCE The number of bacterial organisms increased and the population of conjunctival bacteria was altered and had a higher proportion resistant to ofloxacin during the 6 weeks after cataract surgery for dogs treated by use of this protocol.</description><subject>Animals</subject><subject>Anti-Infective Agents - pharmacology</subject><subject>Anti-Infective Agents - therapeutic use</subject><subject>Cataract - veterinary</subject><subject>Cataract Extraction - veterinary</subject><subject>Conjunctiva - microbiology</subject><subject>Dog Diseases - surgery</subject><subject>Dogs</subject><subject>Drug Resistance, Bacterial</subject><subject>Microbial Sensitivity Tests</subject><subject>Ofloxacin - administration & dosage</subject><subject>Ofloxacin - therapeutic use</subject><subject>Ophthalmic Solutions - pharmacology</subject><subject>Ophthalmic Solutions - therapeutic use</subject><subject>Staphylococcus - drug effects</subject><issn>0002-9645</issn><issn>1943-5681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kU1LxDAQhoMo7vpx9Co9eumaTJs2PS7iFwhe9BzSJF2ytM2apIv7K_zLzrKrkDAw78szzLyE3DC6gLKi92q9DYtaLGABtD4hc9aURc4rwU7JnFIKeVOVfEYuYlxTykAwfk5mWEqK_Tn5WfbJBpWcH2Pmxkz7cT2NOrmt6rNWaRSdytRo8Cc3OB1861CKU9R2k1zrepd2mZmCG1dZ8hunUVVmcKOL6QDOfIev999K4wTVITPTKqmAeASFlQ27_WzjV_GKnHWqj_b6WC_J59Pjx8NL_vb-_PqwfMs1NEXKgXdQQ82g7hTlpmgBQHPBWNNx00LJmCmZtcZyVjWiFmAonoQCVNaUQpjiktwduJvgvyYbkxwcbtT3arR-ipKJqqgZp0WD1vxgxd1jDLaTm-AGFXaSUbnPQO4zkLWQIDED9N8e0VM7WPPv_jt68QuRiYYd</recordid><startdate>201702</startdate><enddate>201702</enddate><creator>Sandmeyer, Lynne S</creator><creator>Bauer, Bianca S</creator><creator>Mohaghegh Poor, Seyed Mohammad</creator><creator>Feng, Cindy Xin</creator><creator>Chirino-Trejo, Manuel</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201702</creationdate><title>Alterations in conjunctival bacteria and antimicrobial susceptibility during topical administration of ofloxacin after cataract surgery in dogs</title><author>Sandmeyer, Lynne S ; Bauer, Bianca S ; Mohaghegh Poor, Seyed Mohammad ; Feng, Cindy Xin ; Chirino-Trejo, Manuel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c293t-25f2727127fa05d3b222c58119f5db2411d41eede51698782d06810226ed488d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Anti-Infective Agents - pharmacology</topic><topic>Anti-Infective Agents - therapeutic use</topic><topic>Cataract - veterinary</topic><topic>Cataract Extraction - veterinary</topic><topic>Conjunctiva - microbiology</topic><topic>Dog Diseases - surgery</topic><topic>Dogs</topic><topic>Drug Resistance, Bacterial</topic><topic>Microbial Sensitivity Tests</topic><topic>Ofloxacin - administration & dosage</topic><topic>Ofloxacin - therapeutic use</topic><topic>Ophthalmic Solutions - pharmacology</topic><topic>Ophthalmic Solutions - therapeutic use</topic><topic>Staphylococcus - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sandmeyer, Lynne S</creatorcontrib><creatorcontrib>Bauer, Bianca S</creatorcontrib><creatorcontrib>Mohaghegh Poor, Seyed Mohammad</creatorcontrib><creatorcontrib>Feng, Cindy Xin</creatorcontrib><creatorcontrib>Chirino-Trejo, Manuel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of veterinary research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sandmeyer, Lynne S</au><au>Bauer, Bianca S</au><au>Mohaghegh Poor, Seyed Mohammad</au><au>Feng, Cindy Xin</au><au>Chirino-Trejo, Manuel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alterations in conjunctival bacteria and antimicrobial susceptibility during topical administration of ofloxacin after cataract surgery in dogs</atitle><jtitle>American journal of veterinary research</jtitle><addtitle>Am J Vet Res</addtitle><date>2017-02</date><risdate>2017</risdate><volume>78</volume><issue>2</issue><spage>207</spage><epage>214</epage><pages>207-214</pages><issn>0002-9645</issn><eissn>1943-5681</eissn><abstract>OBJECTIVE To evaluate changes in conjunctival bacteria and antimicrobial susceptibility of bacteria after cataract surgery in dogs. ANIMALS 16 client-owned dogs. PROCEDURES Samples for aerobic and anaerobic culture were obtained from the conjunctival fornices of both eyes of dogs 24 hours before (week 0) and 1, 3, and 6 weeks after cataract surgery. Topical administration of ofloxacin (every 6 hours) was initiated 12 hours before surgery and continued for 3 weeks. In vitro antimicrobial susceptibility was determined by Kirby-Bauer disk diffusion and a commercially available test for ofloxacin. RESULTS Frequency of positive culture results was significantly higher at week 6 than at weeks 0 and 1. Bacterial load was more likely to be moderate or high at weeks 3 and 6 than at weeks 0 and 1. The most frequently cultured organism was Staphylococcus pseudintermedius (21/78 [26.9%]), followed by coagulase-negative Staphylococcus spp (19/78 [24.4%]). Staphylococcus pseudintermedius was the organism most frequently cultured at weeks 0 (5/12), 1 (4/12), and 6 (8/19), whereas frequency of this organism was lowest at week 3 (1/20). In contrast, coagulase-negative Staphylococcus spp were the most frequently cultured organisms at week 3 (10/20). There was a significant increase in the proportion of organisms resistant to ofloxacin at week 3, compared with the proportion at week 0. CONCLUSIONS AND CLINICAL RELEVANCE The number of bacterial organisms increased and the population of conjunctival bacteria was altered and had a higher proportion resistant to ofloxacin during the 6 weeks after cataract surgery for dogs treated by use of this protocol.</abstract><cop>United States</cop><pmid>28140645</pmid><doi>10.2460/ajvr.78.2.207</doi><tpages>8</tpages></addata></record> |
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subjects | Animals Anti-Infective Agents - pharmacology Anti-Infective Agents - therapeutic use Cataract - veterinary Cataract Extraction - veterinary Conjunctiva - microbiology Dog Diseases - surgery Dogs Drug Resistance, Bacterial Microbial Sensitivity Tests Ofloxacin - administration & dosage Ofloxacin - therapeutic use Ophthalmic Solutions - pharmacology Ophthalmic Solutions - therapeutic use Staphylococcus - drug effects |
title | Alterations in conjunctival bacteria and antimicrobial susceptibility during topical administration of ofloxacin after cataract surgery in dogs |
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