Elevated GDF-15 contributes to pulmonary inflammation upon cigarette smoke exposure

The molecular mechanisms underlying the pathogenesis of chronic obstructive pulmonary disease (COPD) are still unclear, however signaling pathways associated with lung development, such as the transforming growth factor (TGF)-β superfamily, could be implicated in COPD. Growth differentiation factor...

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Veröffentlicht in:	Mucosal immunology 2017-11, Vol.10 (6), p.1400-1411
Hauptverfasser:	Verhamme, F M, Seys, L J M, De Smet, E G, Provoost, S, Janssens, W, Elewaut, D, Joos, G F, Brusselle, G G, Bracke, K R
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/127 631/250/256 692/699/1785 692/699/476/5 Aged Allergology Animals Antibodies article-report Biomedical and Life Sciences Biomedicine Bronchi - pathology Cachexia Cells, Cultured Chronic obstructive pulmonary disease Cigarette smoke Cigarette Smoking - adverse effects Cohort Studies Epithelial cells Epithelial Cells - immunology Epithelium Female Gastroenterology Growth Differentiation Factor 15 - genetics Growth Differentiation Factor 15 - metabolism Health risk assessment Humans Immunohistochemistry Immunology Inflammation Lung diseases Lungs Male Mice Mice, Inbred C57BL Mice, Knockout Middle Aged Molecular modelling Obstructive lung disease Pneumonia - immunology Pulmonary Disease, Chronic Obstructive - immunology Sputum Tobacco smoke Up-Regulation
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