The essential role of the invariant GGQ motif in the function and stability in vivo of bacterial release factors RF1 and RF2

Summary Release factors RF1 and RF2 are required in bacteria for the cleavage of peptidyl‐tRNA. A single sequence motif, GGQ, is conserved in all eubacterial, archaebacterial and eukaryotic release factors and may mimic the CCA end of tRNA, although the position of the motif in the crystal structure...

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Veröffentlicht in:	Molecular microbiology 2003-01, Vol.47 (1), p.267-275
Hauptverfasser:	Mora, Liliana, Heurgué‐Hamard, Valérie, Champ, Stéphanie, Ehrenberg, Måns, Kisselev, Lev L., Buckingham, Richard H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Proteins - genetics Bacterial Proteins - metabolism Blotting, Western Conserved Sequence Escherichia coli - genetics Escherichia coli - metabolism Escherichia coli Proteins Peptide Chain Termination, Translational Peptide Termination Factors - antagonists & inhibitors Peptide Termination Factors - genetics Peptide Termination Factors - metabolism Trans-Activators - metabolism
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