Epidemiological investigation of Candida species causing bloodstream infection in paediatric small bowel transplant recipients
Summary Small bowel transplantation (SBT) can be a life‐saving medical procedure. However, these recipients experience high risk of bloodstream infections caused by Candida. This research aims to characterise the SBT recipient gut microbiota over time following transplantation and investigate the ep...
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| Veröffentlicht in: | Mycoses 2017-06, Vol.60 (6), p.366-374 |
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| creator | Suhr, Mallory J. Gomes‐Neto, João Carlos Banjara, Nabaraj Florescu, Diana F. Mercer, David F. Iwen, Peter C. Hallen‐Adams, Heather E. |
| description | Summary
Small bowel transplantation (SBT) can be a life‐saving medical procedure. However, these recipients experience high risk of bloodstream infections caused by Candida. This research aims to characterise the SBT recipient gut microbiota over time following transplantation and investigate the epidemiology of candidaemia in seven paediatric patients. Candida species from the recipients' ileum and bloodstream were identified by internal transcribed spacer sequence and distinguished to strain by multilocus sequence typing and randomly amplified polymorphic DNA. Antifungal susceptibility of bloodstream isolates was determined against nine antifungals. Twenty‐two ileostomy samples harboured at least one Candida species. Fungaemia were caused by Candida parapsilosis, Candida albicans, Candida glabrata, Candida orthopsilosis and Candida pelliculosa. All but three bloodstream isolates showed susceptibility to all the antifungals tested. One C. glabrata isolate showed multidrug resistance to itraconazole, amphotericin B and posaconazole and intermediate resistance to caspofungin. Results are congruent with both endogenous (C. albicans, C. glabrata) and exogenous (C. parapsilosis) infections; results also suggest two patients were infected by the same strain of C. parapsilosis. Continuing to work towards a better understanding of sources of infection—particularly the exogenous sources—would lead to targeted prevention strategies. |
| doi_str_mv | 10.1111/myc.12603 |
| format | Article |
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Small bowel transplantation (SBT) can be a life‐saving medical procedure. However, these recipients experience high risk of bloodstream infections caused by Candida. This research aims to characterise the SBT recipient gut microbiota over time following transplantation and investigate the epidemiology of candidaemia in seven paediatric patients. Candida species from the recipients' ileum and bloodstream were identified by internal transcribed spacer sequence and distinguished to strain by multilocus sequence typing and randomly amplified polymorphic DNA. Antifungal susceptibility of bloodstream isolates was determined against nine antifungals. Twenty‐two ileostomy samples harboured at least one Candida species. Fungaemia were caused by Candida parapsilosis, Candida albicans, Candida glabrata, Candida orthopsilosis and Candida pelliculosa. All but three bloodstream isolates showed susceptibility to all the antifungals tested. One C. glabrata isolate showed multidrug resistance to itraconazole, amphotericin B and posaconazole and intermediate resistance to caspofungin. Results are congruent with both endogenous (C. albicans, C. glabrata) and exogenous (C. parapsilosis) infections; results also suggest two patients were infected by the same strain of C. parapsilosis. Continuing to work towards a better understanding of sources of infection—particularly the exogenous sources—would lead to targeted prevention strategies.</description><identifier>ISSN: 0933-7407</identifier><identifier>EISSN: 1439-0507</identifier><identifier>DOI: 10.1111/myc.12603</identifier><identifier>PMID: 28139856</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Adolescent ; Adult ; Amphotericin B ; Amphotericin B - therapeutic use ; Antifungal Agents - therapeutic use ; Candida - classification ; Candida - drug effects ; Candida - isolation & purification ; candidaemia ; Candidemia ; Candidemia - blood ; Candidemia - diagnosis ; Candidemia - drug therapy ; Caspofungin ; Deoxyribonucleic acid ; DNA ; DNA, Fungal - genetics ; Drug Resistance, Fungal ; Echinocandins - therapeutic use ; Epidemiology ; Female ; fungaemia ; Health risk assessment ; Humans ; Ileostomy ; Ileum ; Intestinal microflora ; Intestine, Small - microbiology ; Intestine, Small - transplantation ; Itraconazole ; Itraconazole - therapeutic use ; Lipopeptides - therapeutic use ; Male ; microbiota ; Multidrug resistance ; Multilocus Sequence Typing ; mycobiota ; Nucleotide sequence ; Ostomy ; Posaconazole ; Sequence Analysis, DNA ; Small intestine transplantation ; Spacer ; Species ; Transplant Recipients ; Transplantation ; Transplants & implants ; Triazoles - therapeutic use ; Young Adult</subject><ispartof>Mycoses, 2017-06, Vol.60 (6), p.366-374</ispartof><rights>2017 Blackwell Verlag GmbH</rights><rights>2017 Blackwell Verlag GmbH.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3533-cbb565fb2555bbd10e954c5ea37906f3851ecc0a17dcbae4e28a273feb0f42a03</citedby><cites>FETCH-LOGICAL-c3533-cbb565fb2555bbd10e954c5ea37906f3851ecc0a17dcbae4e28a273feb0f42a03</cites><orcidid>0000-0001-7293-0440 ; 0000-0002-1929-725X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fmyc.12603$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fmyc.12603$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28139856$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Suhr, Mallory J.</creatorcontrib><creatorcontrib>Gomes‐Neto, João Carlos</creatorcontrib><creatorcontrib>Banjara, Nabaraj</creatorcontrib><creatorcontrib>Florescu, Diana F.</creatorcontrib><creatorcontrib>Mercer, David F.</creatorcontrib><creatorcontrib>Iwen, Peter C.</creatorcontrib><creatorcontrib>Hallen‐Adams, Heather E.</creatorcontrib><title>Epidemiological investigation of Candida species causing bloodstream infection in paediatric small bowel transplant recipients</title><title>Mycoses</title><addtitle>Mycoses</addtitle><description>Summary
Small bowel transplantation (SBT) can be a life‐saving medical procedure. However, these recipients experience high risk of bloodstream infections caused by Candida. This research aims to characterise the SBT recipient gut microbiota over time following transplantation and investigate the epidemiology of candidaemia in seven paediatric patients. Candida species from the recipients' ileum and bloodstream were identified by internal transcribed spacer sequence and distinguished to strain by multilocus sequence typing and randomly amplified polymorphic DNA. Antifungal susceptibility of bloodstream isolates was determined against nine antifungals. Twenty‐two ileostomy samples harboured at least one Candida species. Fungaemia were caused by Candida parapsilosis, Candida albicans, Candida glabrata, Candida orthopsilosis and Candida pelliculosa. All but three bloodstream isolates showed susceptibility to all the antifungals tested. One C. glabrata isolate showed multidrug resistance to itraconazole, amphotericin B and posaconazole and intermediate resistance to caspofungin. Results are congruent with both endogenous (C. albicans, C. glabrata) and exogenous (C. parapsilosis) infections; results also suggest two patients were infected by the same strain of C. parapsilosis. Continuing to work towards a better understanding of sources of infection—particularly the exogenous sources—would lead to targeted prevention strategies.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Amphotericin B</subject><subject>Amphotericin B - therapeutic use</subject><subject>Antifungal Agents - therapeutic use</subject><subject>Candida - classification</subject><subject>Candida - drug effects</subject><subject>Candida - isolation & purification</subject><subject>candidaemia</subject><subject>Candidemia</subject><subject>Candidemia - blood</subject><subject>Candidemia - diagnosis</subject><subject>Candidemia - drug therapy</subject><subject>Caspofungin</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA, Fungal - genetics</subject><subject>Drug Resistance, Fungal</subject><subject>Echinocandins - therapeutic use</subject><subject>Epidemiology</subject><subject>Female</subject><subject>fungaemia</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Ileostomy</subject><subject>Ileum</subject><subject>Intestinal microflora</subject><subject>Intestine, Small - microbiology</subject><subject>Intestine, Small - transplantation</subject><subject>Itraconazole</subject><subject>Itraconazole - therapeutic use</subject><subject>Lipopeptides - therapeutic use</subject><subject>Male</subject><subject>microbiota</subject><subject>Multidrug resistance</subject><subject>Multilocus Sequence Typing</subject><subject>mycobiota</subject><subject>Nucleotide sequence</subject><subject>Ostomy</subject><subject>Posaconazole</subject><subject>Sequence Analysis, DNA</subject><subject>Small intestine transplantation</subject><subject>Spacer</subject><subject>Species</subject><subject>Transplant Recipients</subject><subject>Transplantation</subject><subject>Transplants & implants</subject><subject>Triazoles - therapeutic use</subject><subject>Young Adult</subject><issn>0933-7407</issn><issn>1439-0507</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kT1PHDEQhq2ICI4LRf5AZIkmFAf-WO9HiU7kQyKiSYpU1tg7ezLy2ou9C7omvz2GIykiZZppnnlmRi8h7zm75KWuxr295KJm8g1Z8Up2G6ZYc0RWrJNy01SsOSGnOd8zxptO1MfkRLRcdq2qV-TXzeR6HF30cecseOrCI-bZ7WB2MdA40C2E3vVA84TWYaYWluzCjhofY5_nhDCWoQHty4ALdALsHczJWZpH8J6a-ISezglCnjyEmaZimhyGOb8jbwfwGc9e-5r8-HTzfftlc3v3-ev2-nZjpSo_WGNUrQYjlFLG9JxhpyqrEGTTsXqQreJoLQPe9NYAVihaEI0c0LChEsDkmnw8eKcUH5byoB5dtujLORiXrHlbSyEEL8vW5Pwf9D4uKZTrNO8EU6qStSjUxYGyKeaccNBTciOkveZMP4eiSyj6JZTCfng1LmbE_i_5J4UCXB2AJ-dx_3-T_vZze1D-Bqh_mRs</recordid><startdate>201706</startdate><enddate>201706</enddate><creator>Suhr, Mallory J.</creator><creator>Gomes‐Neto, João Carlos</creator><creator>Banjara, Nabaraj</creator><creator>Florescu, Diana F.</creator><creator>Mercer, David F.</creator><creator>Iwen, Peter C.</creator><creator>Hallen‐Adams, Heather E.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>M7N</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7293-0440</orcidid><orcidid>https://orcid.org/0000-0002-1929-725X</orcidid></search><sort><creationdate>201706</creationdate><title>Epidemiological investigation of Candida species causing bloodstream infection in paediatric small bowel transplant recipients</title><author>Suhr, Mallory J. ; Gomes‐Neto, João Carlos ; Banjara, Nabaraj ; Florescu, Diana F. ; Mercer, David F. ; Iwen, Peter C. ; Hallen‐Adams, Heather E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3533-cbb565fb2555bbd10e954c5ea37906f3851ecc0a17dcbae4e28a273feb0f42a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Amphotericin B</topic><topic>Amphotericin B - therapeutic use</topic><topic>Antifungal Agents - therapeutic use</topic><topic>Candida - classification</topic><topic>Candida - drug effects</topic><topic>Candida - isolation & purification</topic><topic>candidaemia</topic><topic>Candidemia</topic><topic>Candidemia - blood</topic><topic>Candidemia - diagnosis</topic><topic>Candidemia - drug therapy</topic><topic>Caspofungin</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA, Fungal - genetics</topic><topic>Drug Resistance, Fungal</topic><topic>Echinocandins - therapeutic use</topic><topic>Epidemiology</topic><topic>Female</topic><topic>fungaemia</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>Ileostomy</topic><topic>Ileum</topic><topic>Intestinal microflora</topic><topic>Intestine, Small - microbiology</topic><topic>Intestine, Small - transplantation</topic><topic>Itraconazole</topic><topic>Itraconazole - therapeutic use</topic><topic>Lipopeptides - therapeutic use</topic><topic>Male</topic><topic>microbiota</topic><topic>Multidrug resistance</topic><topic>Multilocus Sequence Typing</topic><topic>mycobiota</topic><topic>Nucleotide sequence</topic><topic>Ostomy</topic><topic>Posaconazole</topic><topic>Sequence Analysis, DNA</topic><topic>Small intestine transplantation</topic><topic>Spacer</topic><topic>Species</topic><topic>Transplant Recipients</topic><topic>Transplantation</topic><topic>Transplants & implants</topic><topic>Triazoles - therapeutic use</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Suhr, Mallory J.</creatorcontrib><creatorcontrib>Gomes‐Neto, João Carlos</creatorcontrib><creatorcontrib>Banjara, Nabaraj</creatorcontrib><creatorcontrib>Florescu, Diana F.</creatorcontrib><creatorcontrib>Mercer, David F.</creatorcontrib><creatorcontrib>Iwen, Peter C.</creatorcontrib><creatorcontrib>Hallen‐Adams, Heather E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Mycoses</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Suhr, Mallory J.</au><au>Gomes‐Neto, João Carlos</au><au>Banjara, Nabaraj</au><au>Florescu, Diana F.</au><au>Mercer, David F.</au><au>Iwen, Peter C.</au><au>Hallen‐Adams, Heather E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epidemiological investigation of Candida species causing bloodstream infection in paediatric small bowel transplant recipients</atitle><jtitle>Mycoses</jtitle><addtitle>Mycoses</addtitle><date>2017-06</date><risdate>2017</risdate><volume>60</volume><issue>6</issue><spage>366</spage><epage>374</epage><pages>366-374</pages><issn>0933-7407</issn><eissn>1439-0507</eissn><abstract>Summary
Small bowel transplantation (SBT) can be a life‐saving medical procedure. However, these recipients experience high risk of bloodstream infections caused by Candida. This research aims to characterise the SBT recipient gut microbiota over time following transplantation and investigate the epidemiology of candidaemia in seven paediatric patients. Candida species from the recipients' ileum and bloodstream were identified by internal transcribed spacer sequence and distinguished to strain by multilocus sequence typing and randomly amplified polymorphic DNA. Antifungal susceptibility of bloodstream isolates was determined against nine antifungals. Twenty‐two ileostomy samples harboured at least one Candida species. Fungaemia were caused by Candida parapsilosis, Candida albicans, Candida glabrata, Candida orthopsilosis and Candida pelliculosa. All but three bloodstream isolates showed susceptibility to all the antifungals tested. One C. glabrata isolate showed multidrug resistance to itraconazole, amphotericin B and posaconazole and intermediate resistance to caspofungin. Results are congruent with both endogenous (C. albicans, C. glabrata) and exogenous (C. parapsilosis) infections; results also suggest two patients were infected by the same strain of C. parapsilosis. Continuing to work towards a better understanding of sources of infection—particularly the exogenous sources—would lead to targeted prevention strategies.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28139856</pmid><doi>10.1111/myc.12603</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-7293-0440</orcidid><orcidid>https://orcid.org/0000-0002-1929-725X</orcidid></addata></record> |
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| ispartof | Mycoses, 2017-06, Vol.60 (6), p.366-374 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adolescent Adult Amphotericin B Amphotericin B - therapeutic use Antifungal Agents - therapeutic use Candida - classification Candida - drug effects Candida - isolation & purification candidaemia Candidemia Candidemia - blood Candidemia - diagnosis Candidemia - drug therapy Caspofungin Deoxyribonucleic acid DNA DNA, Fungal - genetics Drug Resistance, Fungal Echinocandins - therapeutic use Epidemiology Female fungaemia Health risk assessment Humans Ileostomy Ileum Intestinal microflora Intestine, Small - microbiology Intestine, Small - transplantation Itraconazole Itraconazole - therapeutic use Lipopeptides - therapeutic use Male microbiota Multidrug resistance Multilocus Sequence Typing mycobiota Nucleotide sequence Ostomy Posaconazole Sequence Analysis, DNA Small intestine transplantation Spacer Species Transplant Recipients Transplantation Transplants & implants Triazoles - therapeutic use Young Adult |
| title | Epidemiological investigation of Candida species causing bloodstream infection in paediatric small bowel transplant recipients |
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