Comparative Effects of LY3020371, a Potent and Selective Metabotropic Glutamate (mGlu) 2/3 Receptor Antagonist, and Ketamine, a Noncompetitive N-Methyl-d-Aspartate Receptor Antagonist in Rodents: Evidence Supporting the Use of mGlu2/3 Antagonists, for the Treatment of Depression

The ability of the N-methyl-d-aspartate receptor antagonist ketamine to alleviate symptoms in patients suffering from treatment-resistant depression (TRD) is well documented. In this paper, we directly compare in vivo biologic responses in rodents elicited by a recently discovered metabotropic gluta...

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Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2017-04, Vol.361 (1), p.68-86
Hauptverfasser:	Witkin, J.M., Mitchell, S.N., Wafford, K.A., Carter, G., Gilmour, G., Li, J., Eastwood, B.J., Overshiner, C., Li, X., Rorick-Kehn, L., Rasmussen, K., Anderson, W.H., Nikolayev, A., Tolstikov, V.V., Kuo, M.-S., Catlow, J.T., Li, R., Smith, S.C., Mitch, C.H., Ornstein, P.L., Swanson, S., Monn, J.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antidepressive Agents - pharmacology Antidepressive Agents - therapeutic use Depression - drug therapy Depression - metabolism Depression - psychology Excitatory Amino Acid Antagonists - pharmacology Excitatory Amino Acid Antagonists - therapeutic use Hippocampus - drug effects Hippocampus - metabolism Ketamine - pharmacology Ketamine - therapeutic use Male Rats Rats, Sprague-Dawley Rats, Wistar Receptors, Metabotropic Glutamate - antagonists & inhibitors Receptors, Metabotropic Glutamate - metabolism Receptors, Metabotropic Glutamate - physiology Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Receptors, N-Methyl-D-Aspartate - metabolism Treatment Outcome
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