Cardiac Biomarkers of Low Cardiac Output Syndrome in the Postoperative Period After Congenital Heart Disease Surgery in Children
To assess the predictive value of atrial natriuretic peptide, β-type natriuretic peptide, copeptin, mid-regional pro-adrenomedullin (MR-proADM) and cardiac troponin I (cTn-I) as indicators of low cardiac output syndrome in children with congenital heart disease undergoing cardiopulmonary bypass (CPB...
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| Veröffentlicht in: | Revista española de cardiología (English ed.) 2017-04, Vol.70 (4), p.267-274 |
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| creator | Pérez-Navero, Juan L de la Torre-Aguilar, María José Ibarra de la Rosa, Ignacio Gil-Campos, Mercedes Gómez-Guzmán, Elena Merino-Cejas, Carlos Muñoz-Villanueva, María C Llorente-Cantarero, Francisco J |
| description | To assess the predictive value of atrial natriuretic peptide, β-type natriuretic peptide, copeptin, mid-regional pro-adrenomedullin (MR-proADM) and cardiac troponin I (cTn-I) as indicators of low cardiac output syndrome in children with congenital heart disease undergoing cardiopulmonary bypass (CPB).
After corrective surgery for congenital heart disease under CPB, 117 children (aged 10 days to 180 months) were enrolled in a prospective observational pilot study during a 2-year period. The patients were classified according to whether they developed low cardiac output syndrome. Biomarker levels were measured at 2, 12, 24, and 48 hours post-CPB. The clinical data and outcome variables were analyzed by a multiple logistic regression model.
Thirty-three (29%) patients developed low cardiac output syndrome (group 1) and the remaining 84 (71%) patients were included in group 2. cTn-I levels >14 ng/mL at 2hours after CPB (OR, 4.05; 95%CI, 1.29-12.64; P=.016) and MR-proADM levels>1.5 nmol/L at 24hours following CPB (OR, 15.54; 95%CI, 4.41-54.71; P |
| doi_str_mv | 10.1016/j.rec.2016.09.011 |
| format | Article |
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After corrective surgery for congenital heart disease under CPB, 117 children (aged 10 days to 180 months) were enrolled in a prospective observational pilot study during a 2-year period. The patients were classified according to whether they developed low cardiac output syndrome. Biomarker levels were measured at 2, 12, 24, and 48 hours post-CPB. The clinical data and outcome variables were analyzed by a multiple logistic regression model.
Thirty-three (29%) patients developed low cardiac output syndrome (group 1) and the remaining 84 (71%) patients were included in group 2. cTn-I levels >14 ng/mL at 2hours after CPB (OR, 4.05; 95%CI, 1.29-12.64; P=.016) and MR-proADM levels>1.5 nmol/L at 24hours following CPB (OR, 15.54; 95%CI, 4.41-54.71; P<.001) were independent predictors of low cardiac output syndrome.
Our results suggest that cTn-I at 2hours post-CPB is, by itself, an evident independent early predictor of low cardiac output syndrome. This predictive capacity is, moreover, reinforced when cTn-I is combined with MR-proADM levels at 24hours following CPB. These 2 cardiac biomarkers would aid in therapeutic decision-making in clinical practice and would also enable clinicians to modify the type of support to be used in the pediatric intensive care unit.</description><identifier>ISSN: 1885-5857</identifier><identifier>EISSN: 1885-5857</identifier><identifier>DOI: 10.1016/j.rec.2016.09.011</identifier><identifier>PMID: 28137395</identifier><language>eng</language><publisher>Spain</publisher><subject>Adrenomedullin - metabolism ; Analysis of Variance ; Biomarkers - metabolism ; Cardiac Output, Low - diagnosis ; Cardiopulmonary Bypass - methods ; Child ; Child, Preschool ; Female ; Heart Defects, Congenital - surgery ; Humans ; Infant ; Infant, Newborn ; Male ; Operative Time ; Peptide Fragments - metabolism ; Pilot Projects ; Postoperative Complications - diagnosis ; Protein Precursors - metabolism ; Troponin - metabolism</subject><ispartof>Revista española de cardiología (English ed.), 2017-04, Vol.70 (4), p.267-274</ispartof><rights>Copyright © 2016 Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c231t-b34dc2853fc266f0dc41e7fe1df310845bcea22ea9e1873a7aceaef460bc91643</citedby><cites>FETCH-LOGICAL-c231t-b34dc2853fc266f0dc41e7fe1df310845bcea22ea9e1873a7aceaef460bc91643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28137395$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pérez-Navero, Juan L</creatorcontrib><creatorcontrib>de la Torre-Aguilar, María José</creatorcontrib><creatorcontrib>Ibarra de la Rosa, Ignacio</creatorcontrib><creatorcontrib>Gil-Campos, Mercedes</creatorcontrib><creatorcontrib>Gómez-Guzmán, Elena</creatorcontrib><creatorcontrib>Merino-Cejas, Carlos</creatorcontrib><creatorcontrib>Muñoz-Villanueva, María C</creatorcontrib><creatorcontrib>Llorente-Cantarero, Francisco J</creatorcontrib><title>Cardiac Biomarkers of Low Cardiac Output Syndrome in the Postoperative Period After Congenital Heart Disease Surgery in Children</title><title>Revista española de cardiología (English ed.)</title><addtitle>Rev Esp Cardiol (Engl Ed)</addtitle><description>To assess the predictive value of atrial natriuretic peptide, β-type natriuretic peptide, copeptin, mid-regional pro-adrenomedullin (MR-proADM) and cardiac troponin I (cTn-I) as indicators of low cardiac output syndrome in children with congenital heart disease undergoing cardiopulmonary bypass (CPB).
After corrective surgery for congenital heart disease under CPB, 117 children (aged 10 days to 180 months) were enrolled in a prospective observational pilot study during a 2-year period. The patients were classified according to whether they developed low cardiac output syndrome. Biomarker levels were measured at 2, 12, 24, and 48 hours post-CPB. The clinical data and outcome variables were analyzed by a multiple logistic regression model.
Thirty-three (29%) patients developed low cardiac output syndrome (group 1) and the remaining 84 (71%) patients were included in group 2. cTn-I levels >14 ng/mL at 2hours after CPB (OR, 4.05; 95%CI, 1.29-12.64; P=.016) and MR-proADM levels>1.5 nmol/L at 24hours following CPB (OR, 15.54; 95%CI, 4.41-54.71; P<.001) were independent predictors of low cardiac output syndrome.
Our results suggest that cTn-I at 2hours post-CPB is, by itself, an evident independent early predictor of low cardiac output syndrome. This predictive capacity is, moreover, reinforced when cTn-I is combined with MR-proADM levels at 24hours following CPB. These 2 cardiac biomarkers would aid in therapeutic decision-making in clinical practice and would also enable clinicians to modify the type of support to be used in the pediatric intensive care unit.</description><subject>Adrenomedullin - metabolism</subject><subject>Analysis of Variance</subject><subject>Biomarkers - metabolism</subject><subject>Cardiac Output, Low - diagnosis</subject><subject>Cardiopulmonary Bypass - methods</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Heart Defects, Congenital - surgery</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Male</subject><subject>Operative Time</subject><subject>Peptide Fragments - metabolism</subject><subject>Pilot Projects</subject><subject>Postoperative Complications - diagnosis</subject><subject>Protein Precursors - metabolism</subject><subject>Troponin - metabolism</subject><issn>1885-5857</issn><issn>1885-5857</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkDlPxDAQhS0E4v4BNMglzQZPnMMpIZzSSiABteV1xuAlGy-2A9qOn45XHKKZmad57xUfIUfAMmBQnc4zjzrL05mxJmMAG2QXhCgnpSjrzX_3DtkLYc5YyUVdbJOdXACveVPuks9W-c4qTc-tWyj_ij5QZ-jUfdDfz90Yl2OkD6uh826B1A40viC9dyG6JXoV7XtS6K3r6JmJ6GnrhmccbFQ9vUHlI72wAVVA-jD6Z_SrdUX7YvvO43BAtozqAx7-7H3ydHX52N5MpnfXt-3ZdKJzDnEy40Wnc1Fyo_OqMqzTBWBtEDrDgYminGlUeY6qQRA1V7VKGk1RsZluoCr4Pjn57l169zZiiHJhg8a-VwO6MUgQFc_TYJCs8G3V3oXg0ciltwnOSgKTa_ByLhN4uQYvWSMT-JQ5_qkfZwvs_hK_pPkXQ5GBnw</recordid><startdate>201704</startdate><enddate>201704</enddate><creator>Pérez-Navero, Juan L</creator><creator>de la Torre-Aguilar, María José</creator><creator>Ibarra de la Rosa, Ignacio</creator><creator>Gil-Campos, Mercedes</creator><creator>Gómez-Guzmán, Elena</creator><creator>Merino-Cejas, Carlos</creator><creator>Muñoz-Villanueva, María C</creator><creator>Llorente-Cantarero, Francisco J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201704</creationdate><title>Cardiac Biomarkers of Low Cardiac Output Syndrome in the Postoperative Period After Congenital Heart Disease Surgery in Children</title><author>Pérez-Navero, Juan L ; de la Torre-Aguilar, María José ; Ibarra de la Rosa, Ignacio ; Gil-Campos, Mercedes ; Gómez-Guzmán, Elena ; Merino-Cejas, Carlos ; Muñoz-Villanueva, María C ; Llorente-Cantarero, Francisco J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c231t-b34dc2853fc266f0dc41e7fe1df310845bcea22ea9e1873a7aceaef460bc91643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adrenomedullin - metabolism</topic><topic>Analysis of Variance</topic><topic>Biomarkers - metabolism</topic><topic>Cardiac Output, Low - diagnosis</topic><topic>Cardiopulmonary Bypass - methods</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Heart Defects, Congenital - surgery</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Male</topic><topic>Operative Time</topic><topic>Peptide Fragments - metabolism</topic><topic>Pilot Projects</topic><topic>Postoperative Complications - diagnosis</topic><topic>Protein Precursors - metabolism</topic><topic>Troponin - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pérez-Navero, Juan L</creatorcontrib><creatorcontrib>de la Torre-Aguilar, María José</creatorcontrib><creatorcontrib>Ibarra de la Rosa, Ignacio</creatorcontrib><creatorcontrib>Gil-Campos, Mercedes</creatorcontrib><creatorcontrib>Gómez-Guzmán, Elena</creatorcontrib><creatorcontrib>Merino-Cejas, Carlos</creatorcontrib><creatorcontrib>Muñoz-Villanueva, María C</creatorcontrib><creatorcontrib>Llorente-Cantarero, Francisco J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Revista española de cardiología (English ed.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pérez-Navero, Juan L</au><au>de la Torre-Aguilar, María José</au><au>Ibarra de la Rosa, Ignacio</au><au>Gil-Campos, Mercedes</au><au>Gómez-Guzmán, Elena</au><au>Merino-Cejas, Carlos</au><au>Muñoz-Villanueva, María C</au><au>Llorente-Cantarero, Francisco J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cardiac Biomarkers of Low Cardiac Output Syndrome in the Postoperative Period After Congenital Heart Disease Surgery in Children</atitle><jtitle>Revista española de cardiología (English ed.)</jtitle><addtitle>Rev Esp Cardiol (Engl Ed)</addtitle><date>2017-04</date><risdate>2017</risdate><volume>70</volume><issue>4</issue><spage>267</spage><epage>274</epage><pages>267-274</pages><issn>1885-5857</issn><eissn>1885-5857</eissn><abstract>To assess the predictive value of atrial natriuretic peptide, β-type natriuretic peptide, copeptin, mid-regional pro-adrenomedullin (MR-proADM) and cardiac troponin I (cTn-I) as indicators of low cardiac output syndrome in children with congenital heart disease undergoing cardiopulmonary bypass (CPB).
After corrective surgery for congenital heart disease under CPB, 117 children (aged 10 days to 180 months) were enrolled in a prospective observational pilot study during a 2-year period. The patients were classified according to whether they developed low cardiac output syndrome. Biomarker levels were measured at 2, 12, 24, and 48 hours post-CPB. The clinical data and outcome variables were analyzed by a multiple logistic regression model.
Thirty-three (29%) patients developed low cardiac output syndrome (group 1) and the remaining 84 (71%) patients were included in group 2. cTn-I levels >14 ng/mL at 2hours after CPB (OR, 4.05; 95%CI, 1.29-12.64; P=.016) and MR-proADM levels>1.5 nmol/L at 24hours following CPB (OR, 15.54; 95%CI, 4.41-54.71; P<.001) were independent predictors of low cardiac output syndrome.
Our results suggest that cTn-I at 2hours post-CPB is, by itself, an evident independent early predictor of low cardiac output syndrome. This predictive capacity is, moreover, reinforced when cTn-I is combined with MR-proADM levels at 24hours following CPB. These 2 cardiac biomarkers would aid in therapeutic decision-making in clinical practice and would also enable clinicians to modify the type of support to be used in the pediatric intensive care unit.</abstract><cop>Spain</cop><pmid>28137395</pmid><doi>10.1016/j.rec.2016.09.011</doi><tpages>8</tpages></addata></record> |
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| ispartof | Revista española de cardiología (English ed.), 2017-04, Vol.70 (4), p.267-274 |
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| subjects | Adrenomedullin - metabolism Analysis of Variance Biomarkers - metabolism Cardiac Output, Low - diagnosis Cardiopulmonary Bypass - methods Child Child, Preschool Female Heart Defects, Congenital - surgery Humans Infant Infant, Newborn Male Operative Time Peptide Fragments - metabolism Pilot Projects Postoperative Complications - diagnosis Protein Precursors - metabolism Troponin - metabolism |
| title | Cardiac Biomarkers of Low Cardiac Output Syndrome in the Postoperative Period After Congenital Heart Disease Surgery in Children |
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