Drug Target Identification Using an iTRAQ-Based Quantitative Chemical Proteomics Approach-Based on a Target Profiling Study of Andrographolide

Identifying the cellular binding targets of drugs and other bioactive small molecules is a crucial step for understanding their molecular mechanisms of action as well as potential off-target effects. The field of chemical proteomics is an emerging discipline in chemical biology using synthetic chemi...

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Veröffentlicht in:	Methods in enzymology 2017, Vol.586, p.291-309
Hauptverfasser:	Wang, J, Wong, Y K, Zhang, J, Lee, Y-M, Hua, Z-C, Shen, H-M, Lin, Q
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkynes - chemistry Chromatography, Liquid Click Chemistry Diterpenes - chemistry HCT116 Cells Humans Protein Binding Proteome - chemistry Proteome - isolation & purification Proteomics Staining and Labeling Tandem Mass Spectrometry
Online-Zugang:	Volltext
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