SIRT1-PGC1 alpha -NFKB Pathway of Oxidative and Inflammatory Stress during Trypanosoma cruzi Infection: Benefits of SIRT1-Targeted Therapy in Improving Heart Function in Chagas Disease

Chronic chagasic cardiomyopathy (CCM) is presented by increased oxidative/inflammatory stress and decreased mitochondrial bioenergetics. SIRT1 senses the redox changes and integrates mitochondrial metabolism and inflammation; and SIRT1 deficiency may be a major determinant in CCM. To test this, C57B...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	PLoS pathogens 2016-10, Vol.12 (10)
Hauptverfasser:	Wan, Xianxiu, Wen, Jian-jun, Koo, Sue-Jie, Liang, Lisa Yi, Garg, Nisha Jain
Format:	Artikel
Sprache:	eng
Schlagworte:	Trypanosoma cruzi
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!