Abnormal Methylation of Imprinted Genes and Cigarette Smoking: Assessment of Their Association With the Risk of Male Infertility
Male infertility is a complicated disease with causes generally split into 2 broad categories: genetic factors and environmental factors. The present study was designed to investigate the association between the methylation patterns of H19 and SNRPN imprinting control region (ICR) and male infertili...
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| Veröffentlicht in: | Reproductive sciences (Thousand Oaks, Calif.) Calif.), 2017-01, Vol.24 (1), p.114-123 |
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| container_title | Reproductive sciences (Thousand Oaks, Calif.) |
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| creator | Dong, Hao Wang, Youxin Zou, Zhikang Chen, Limin Shen, Chuanyun Xu, Shaoqiang Zhang, Jie Zhao, Feifei Ge, Siqi Gao, Qing Hu, Haixiang Song, Manshu Wang, Wei |
| description | Male infertility is a complicated disease with causes generally split into 2 broad categories: genetic factors and environmental factors. The present study was designed to investigate the association between the methylation patterns of H19 and SNRPN imprinting control region (ICR) and male infertility and to assess the gene–environment interactions between environmental factors and methylation patterns. A total of 205 DNA samples from 48 oligozoospermia (OZ), 52 asthenozoospermia (AZ), 55 teratozoospermia (TZ) patients, and 50 normozoospermia (NZ) men were analyzed. The mean methylation level of H19-ICR in OZ (80.40% ± 12.74%) and AZ patients (81.17% ± 13.18%) was significantly lower than methylation in men with NZ (88.51% ± 10.54%, P |
| doi_str_mv | 10.1177/1933719116650755 |
| format | Article |
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The present study was designed to investigate the association between the methylation patterns of H19 and SNRPN imprinting control region (ICR) and male infertility and to assess the gene–environment interactions between environmental factors and methylation patterns. A total of 205 DNA samples from 48 oligozoospermia (OZ), 52 asthenozoospermia (AZ), 55 teratozoospermia (TZ) patients, and 50 normozoospermia (NZ) men were analyzed. The mean methylation level of H19-ICR in OZ (80.40% ± 12.74%) and AZ patients (81.17% ± 13.18%) was significantly lower than methylation in men with NZ (88.51% ± 10.54%, P<.001, P<.001, respectively). The mean methylation level of SNRPN-ICR in AZ patients (7.74% ± 5.71%) and TZ patients (9.33% ± 5.48%) was significantly higher than in NZ men (6.32% ± 3.54%, P<.001, P<.001, respectively). Among environmental factors, smoking was correlated with OZ (odds ratio [OR] = 5.12, 95% CI: 2.05-12.83), AZ (OR = 5.65, 95% CI: 2.13-14.99), and TZ (OR = 5.54, 95% CI: 2.21-13.89). Gene–environment interaction analysis revealed that hypomethylation of H19-ICR in OZ patients and hypermethylation of SNRPN-ICR in AZ and TZ patients were significantly associated with an increased the risk of infertility in men who were smokers (OR = 15.30, 95% CI: 1.13-207.97; OR = 13.20, 95% CI: 1.21-143.57; OR = 10.59, 95% CI: 1.04-107.39, respectively). This study demonstrated that hypomethylation of H19-ICR and hypermethylation of SNRPN-ICR are associated with male infertility, and the risk is potentiated by smoking.</description><identifier>ISSN: 1933-7191</identifier><identifier>EISSN: 1933-7205</identifier><identifier>DOI: 10.1177/1933719116650755</identifier><identifier>PMID: 27247128</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Embryology ; Medicine & Public Health ; Obstetrics/Perinatology/Midwifery ; Original Article ; Reproductive Medicine</subject><ispartof>Reproductive sciences (Thousand Oaks, Calif.), 2017-01, Vol.24 (1), p.114-123</ispartof><rights>The Author(s) 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-35706c3042f6e73705b7c49b2acaff374e01e45d82a5f4a34c4ef1db4a04efe03</citedby><cites>FETCH-LOGICAL-c412t-35706c3042f6e73705b7c49b2acaff374e01e45d82a5f4a34c4ef1db4a04efe03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/1933719116650755$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/1933719116650755$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21819,27924,27925,41488,42557,43621,43622,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27247128$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dong, Hao</creatorcontrib><creatorcontrib>Wang, Youxin</creatorcontrib><creatorcontrib>Zou, Zhikang</creatorcontrib><creatorcontrib>Chen, Limin</creatorcontrib><creatorcontrib>Shen, Chuanyun</creatorcontrib><creatorcontrib>Xu, Shaoqiang</creatorcontrib><creatorcontrib>Zhang, Jie</creatorcontrib><creatorcontrib>Zhao, Feifei</creatorcontrib><creatorcontrib>Ge, Siqi</creatorcontrib><creatorcontrib>Gao, Qing</creatorcontrib><creatorcontrib>Hu, Haixiang</creatorcontrib><creatorcontrib>Song, Manshu</creatorcontrib><creatorcontrib>Wang, Wei</creatorcontrib><title>Abnormal Methylation of Imprinted Genes and Cigarette Smoking: Assessment of Their Association With the Risk of Male Infertility</title><title>Reproductive sciences (Thousand Oaks, Calif.)</title><addtitle>Reprod. Sci</addtitle><addtitle>Reprod Sci</addtitle><description>Male infertility is a complicated disease with causes generally split into 2 broad categories: genetic factors and environmental factors. The present study was designed to investigate the association between the methylation patterns of H19 and SNRPN imprinting control region (ICR) and male infertility and to assess the gene–environment interactions between environmental factors and methylation patterns. A total of 205 DNA samples from 48 oligozoospermia (OZ), 52 asthenozoospermia (AZ), 55 teratozoospermia (TZ) patients, and 50 normozoospermia (NZ) men were analyzed. The mean methylation level of H19-ICR in OZ (80.40% ± 12.74%) and AZ patients (81.17% ± 13.18%) was significantly lower than methylation in men with NZ (88.51% ± 10.54%, P<.001, P<.001, respectively). The mean methylation level of SNRPN-ICR in AZ patients (7.74% ± 5.71%) and TZ patients (9.33% ± 5.48%) was significantly higher than in NZ men (6.32% ± 3.54%, P<.001, P<.001, respectively). Among environmental factors, smoking was correlated with OZ (odds ratio [OR] = 5.12, 95% CI: 2.05-12.83), AZ (OR = 5.65, 95% CI: 2.13-14.99), and TZ (OR = 5.54, 95% CI: 2.21-13.89). Gene–environment interaction analysis revealed that hypomethylation of H19-ICR in OZ patients and hypermethylation of SNRPN-ICR in AZ and TZ patients were significantly associated with an increased the risk of infertility in men who were smokers (OR = 15.30, 95% CI: 1.13-207.97; OR = 13.20, 95% CI: 1.21-143.57; OR = 10.59, 95% CI: 1.04-107.39, respectively). This study demonstrated that hypomethylation of H19-ICR and hypermethylation of SNRPN-ICR are associated with male infertility, and the risk is potentiated by smoking.</description><subject>Embryology</subject><subject>Medicine & Public Health</subject><subject>Obstetrics/Perinatology/Midwifery</subject><subject>Original Article</subject><subject>Reproductive Medicine</subject><issn>1933-7191</issn><issn>1933-7205</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNqNkD1PwzAURS0EoqWwM6GMLAF_OxkYqgpKpSIGYI6c5DmkJHaxk6H_nlRtGRhQp_f0fO6VfBC6JviOEKXuScqYIikhUgqshDhB4-0pVhSL08M-vI_QRQgrjAVPaXKORlRRrghNxuhhmlvnW91EL9B9bhrd1c5GzkSLdu1r20EZzcFCiLQto1ldaQ9dB9Fb675qW12iM6ObAFf7OUEfT4_vs-d4-TpfzKbLuOCEdjETCsuCYU6NBMUUFrkqeJpTXWhjmOKACXBRJlQLwzXjBQdDypxrPCyA2QTd7nrX3n33ELqsrUMBTaMtuD5kJJGMEswUPQKlUqZK0GRA8Q4tvAvBg8mGL7fabzKCs63f7K_fIXKzb-_zFsrfwEHoAJAdELb6KvDZyvXeDnL-K433GV3BEfwPajKPig</recordid><startdate>201701</startdate><enddate>201701</enddate><creator>Dong, Hao</creator><creator>Wang, Youxin</creator><creator>Zou, Zhikang</creator><creator>Chen, Limin</creator><creator>Shen, Chuanyun</creator><creator>Xu, Shaoqiang</creator><creator>Zhang, Jie</creator><creator>Zhao, Feifei</creator><creator>Ge, Siqi</creator><creator>Gao, Qing</creator><creator>Hu, Haixiang</creator><creator>Song, Manshu</creator><creator>Wang, Wei</creator><general>SAGE Publications</general><general>Springer International Publishing</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TM</scope></search><sort><creationdate>201701</creationdate><title>Abnormal Methylation of Imprinted Genes and Cigarette Smoking</title><author>Dong, Hao ; Wang, Youxin ; Zou, Zhikang ; Chen, Limin ; Shen, Chuanyun ; Xu, Shaoqiang ; Zhang, Jie ; Zhao, Feifei ; Ge, Siqi ; Gao, Qing ; Hu, Haixiang ; Song, Manshu ; Wang, Wei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-35706c3042f6e73705b7c49b2acaff374e01e45d82a5f4a34c4ef1db4a04efe03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Embryology</topic><topic>Medicine & Public Health</topic><topic>Obstetrics/Perinatology/Midwifery</topic><topic>Original Article</topic><topic>Reproductive Medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dong, Hao</creatorcontrib><creatorcontrib>Wang, Youxin</creatorcontrib><creatorcontrib>Zou, Zhikang</creatorcontrib><creatorcontrib>Chen, Limin</creatorcontrib><creatorcontrib>Shen, Chuanyun</creatorcontrib><creatorcontrib>Xu, Shaoqiang</creatorcontrib><creatorcontrib>Zhang, Jie</creatorcontrib><creatorcontrib>Zhao, Feifei</creatorcontrib><creatorcontrib>Ge, Siqi</creatorcontrib><creatorcontrib>Gao, Qing</creatorcontrib><creatorcontrib>Hu, Haixiang</creatorcontrib><creatorcontrib>Song, Manshu</creatorcontrib><creatorcontrib>Wang, Wei</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Nucleic Acids Abstracts</collection><jtitle>Reproductive sciences (Thousand Oaks, Calif.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dong, Hao</au><au>Wang, Youxin</au><au>Zou, Zhikang</au><au>Chen, Limin</au><au>Shen, Chuanyun</au><au>Xu, Shaoqiang</au><au>Zhang, Jie</au><au>Zhao, Feifei</au><au>Ge, Siqi</au><au>Gao, Qing</au><au>Hu, Haixiang</au><au>Song, Manshu</au><au>Wang, Wei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Abnormal Methylation of Imprinted Genes and Cigarette Smoking: Assessment of Their Association With the Risk of Male Infertility</atitle><jtitle>Reproductive sciences (Thousand Oaks, Calif.)</jtitle><stitle>Reprod. Sci</stitle><addtitle>Reprod Sci</addtitle><date>2017-01</date><risdate>2017</risdate><volume>24</volume><issue>1</issue><spage>114</spage><epage>123</epage><pages>114-123</pages><issn>1933-7191</issn><eissn>1933-7205</eissn><abstract>Male infertility is a complicated disease with causes generally split into 2 broad categories: genetic factors and environmental factors. The present study was designed to investigate the association between the methylation patterns of H19 and SNRPN imprinting control region (ICR) and male infertility and to assess the gene–environment interactions between environmental factors and methylation patterns. A total of 205 DNA samples from 48 oligozoospermia (OZ), 52 asthenozoospermia (AZ), 55 teratozoospermia (TZ) patients, and 50 normozoospermia (NZ) men were analyzed. The mean methylation level of H19-ICR in OZ (80.40% ± 12.74%) and AZ patients (81.17% ± 13.18%) was significantly lower than methylation in men with NZ (88.51% ± 10.54%, P<.001, P<.001, respectively). The mean methylation level of SNRPN-ICR in AZ patients (7.74% ± 5.71%) and TZ patients (9.33% ± 5.48%) was significantly higher than in NZ men (6.32% ± 3.54%, P<.001, P<.001, respectively). Among environmental factors, smoking was correlated with OZ (odds ratio [OR] = 5.12, 95% CI: 2.05-12.83), AZ (OR = 5.65, 95% CI: 2.13-14.99), and TZ (OR = 5.54, 95% CI: 2.21-13.89). Gene–environment interaction analysis revealed that hypomethylation of H19-ICR in OZ patients and hypermethylation of SNRPN-ICR in AZ and TZ patients were significantly associated with an increased the risk of infertility in men who were smokers (OR = 15.30, 95% CI: 1.13-207.97; OR = 13.20, 95% CI: 1.21-143.57; OR = 10.59, 95% CI: 1.04-107.39, respectively). This study demonstrated that hypomethylation of H19-ICR and hypermethylation of SNRPN-ICR are associated with male infertility, and the risk is potentiated by smoking.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>27247128</pmid><doi>10.1177/1933719116650755</doi><tpages>10</tpages></addata></record> |
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| subjects | Embryology Medicine & Public Health Obstetrics/Perinatology/Midwifery Original Article Reproductive Medicine |
| title | Abnormal Methylation of Imprinted Genes and Cigarette Smoking: Assessment of Their Association With the Risk of Male Infertility |
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