Epigenetic Mechanisms in Psychiatric Diseases and Epigenetic Therapy
ABSTRACT Preclinical Research Epigenetic mechanisms refer covalent modification of DNA and histone proteins that control transcriptional regulation of gene expression. Epigenetic regulation is involved in the development of the nervous system and plays an important role in the pathophysiology of psy...
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| Veröffentlicht in: | Drug development research 2016-11, Vol.77 (7), p.407-413 |
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| container_title | Drug development research |
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| creator | Karsli-Ceppioglu, Seher |
| description | ABSTRACT
Preclinical Research
Epigenetic mechanisms refer covalent modification of DNA and histone proteins that control transcriptional regulation of gene expression. Epigenetic regulation is involved in the development of the nervous system and plays an important role in the pathophysiology of psychiatric disorders, including depression, bipolar disorder, and schizophrenia. Epigenetic drugs, including histone deacetylation and DNA methylation inhibitors have received increased attention for the management of psychiatric diseases. The purpose of this review is to discuss the potential of epigenetic drugs to treat these disorders and to clarify the mechanisms by which they regulate the dysfunctional genes in the brain. Drug Dev Res 77 : 407–413, 2016. © 2016 Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/ddr.21340 |
| format | Article |
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Preclinical Research
Epigenetic mechanisms refer covalent modification of DNA and histone proteins that control transcriptional regulation of gene expression. Epigenetic regulation is involved in the development of the nervous system and plays an important role in the pathophysiology of psychiatric disorders, including depression, bipolar disorder, and schizophrenia. Epigenetic drugs, including histone deacetylation and DNA methylation inhibitors have received increased attention for the management of psychiatric diseases. The purpose of this review is to discuss the potential of epigenetic drugs to treat these disorders and to clarify the mechanisms by which they regulate the dysfunctional genes in the brain. Drug Dev Res 77 : 407–413, 2016. © 2016 Wiley Periodicals, Inc.</description><identifier>ISSN: 0272-4391</identifier><identifier>EISSN: 1098-2299</identifier><identifier>DOI: 10.1002/ddr.21340</identifier><identifier>PMID: 27594444</identifier><identifier>CODEN: DDREDK</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Animals ; DNA Methylation - drug effects ; DNMT inhibitors ; Drug Design ; Epigenesis, Genetic ; epigenetics ; Gene Expression Regulation ; HDAC inhibitors ; Histone Deacetylase Inhibitors - pharmacology ; Humans ; Mental Disorders - drug therapy ; Mental Disorders - genetics ; Mental Disorders - physiopathology ; psychiatric diseases</subject><ispartof>Drug development research, 2016-11, Vol.77 (7), p.407-413</ispartof><rights>2016 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4240-7b414af1f0d34168e109a49d35485850918301b758474983c55b67cd9b9c08313</citedby><cites>FETCH-LOGICAL-c4240-7b414af1f0d34168e109a49d35485850918301b758474983c55b67cd9b9c08313</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fddr.21340$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fddr.21340$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27594444$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Karsli-Ceppioglu, Seher</creatorcontrib><title>Epigenetic Mechanisms in Psychiatric Diseases and Epigenetic Therapy</title><title>Drug development research</title><addtitle>Drug Dev. Res</addtitle><description>ABSTRACT
Preclinical Research
Epigenetic mechanisms refer covalent modification of DNA and histone proteins that control transcriptional regulation of gene expression. Epigenetic regulation is involved in the development of the nervous system and plays an important role in the pathophysiology of psychiatric disorders, including depression, bipolar disorder, and schizophrenia. Epigenetic drugs, including histone deacetylation and DNA methylation inhibitors have received increased attention for the management of psychiatric diseases. The purpose of this review is to discuss the potential of epigenetic drugs to treat these disorders and to clarify the mechanisms by which they regulate the dysfunctional genes in the brain. 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Preclinical Research
Epigenetic mechanisms refer covalent modification of DNA and histone proteins that control transcriptional regulation of gene expression. Epigenetic regulation is involved in the development of the nervous system and plays an important role in the pathophysiology of psychiatric disorders, including depression, bipolar disorder, and schizophrenia. Epigenetic drugs, including histone deacetylation and DNA methylation inhibitors have received increased attention for the management of psychiatric diseases. The purpose of this review is to discuss the potential of epigenetic drugs to treat these disorders and to clarify the mechanisms by which they regulate the dysfunctional genes in the brain. Drug Dev Res 77 : 407–413, 2016. © 2016 Wiley Periodicals, Inc.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>27594444</pmid><doi>10.1002/ddr.21340</doi><tpages>7</tpages></addata></record> |
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| ispartof | Drug development research, 2016-11, Vol.77 (7), p.407-413 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals DNA Methylation - drug effects DNMT inhibitors Drug Design Epigenesis, Genetic epigenetics Gene Expression Regulation HDAC inhibitors Histone Deacetylase Inhibitors - pharmacology Humans Mental Disorders - drug therapy Mental Disorders - genetics Mental Disorders - physiopathology psychiatric diseases |
| title | Epigenetic Mechanisms in Psychiatric Diseases and Epigenetic Therapy |
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