A Truncated Form of Nef Selected during Pathogenic Reversion of Simian Immunodeficiency Virus SIVmac239[Delta]nef Increases Viral Replication

The live, attenuated vaccine simian immunodeficiency virus SIVmac239[Delta]nef efficiently protects rhesus macaques against infection with wild-type SIVmac but occasionally causes CD4 super(+) T-cell depletion and progression to simian AIDS (SAIDS). Virus recovered from a vaccinated macaque (Rh1490)...

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Veröffentlicht in:	Journal of virology 2003-01, Vol.77 (2), p.1245-1256
Hauptverfasser:	Chakrabarti, LA, Metzner, K J, Ivanovic, T, Cheng, H, Louis-Virelizier, J, Connor, R I, Cheng-Mayer, C
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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