Nano-mechanical characterization of tension-sensitive helix bundles in talin rod

Tension-induced exposure of a cryptic signaling binding site is one of the most fundamental mechanisms in molecular mechanotransduction. Helix bundles in rod domains of talin, a tension-sensing protein at focal adhesions, unfurl under tension to expose cryptic vinculin binding sites. Although the di...

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Veröffentlicht in:	Biochemical and biophysical research communications 2017-03, Vol.484 (2), p.372-377
Hauptverfasser:	Maki, Koichiro, Nakao, Nobuhiko, Adachi, Taiji
Format:	Artikel
Sprache:	eng
Schlagworte:	Atomic force microscopy (AFM) Helix bundle Mechanotransduction Microscopy, Atomic Force Nano-tensile testing Nanotechnology Protein Conformation Talin Talin - chemistry Tensile Strength Vinculin
Online-Zugang:	Volltext
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