Low concentration of uncouplers of oxidative phosphorylation decreases the TNF-induced endothelial permeability and lethality in mice

Mitochondrial dysfunctions occur in many diseases linked to the systemic inflammatory response syndrome (SIRS). Mild uncoupling of oxidative phosphorylation is known to rescue model animals from pathologies related to mitochondrial dysfunctions and overproduction of reactive oxygen species (ROS). To...

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Veröffentlicht in:	Biochimica et biophysica acta. Molecular basis of disease 2017-04, Vol.1863 (4), p.968-977
Hauptverfasser:	Zakharova, Vlada V., Pletjushkina, Olga Yu, Galkin, Ivan I., Zinovkin, Roman A., Chernyak, Boris V., Krysko, Dmitri V., Bachert, Claus, Krysko, Olga, Skulachev, Vladimir P., Popova, Ekaterina N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Endothelium Mild uncoupling of oxidative phosphorylation Mitochondria Mitochondria-targeted antioxidant SkQ1
Online-Zugang:	Volltext
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