Orcinol derivative compound with antioxidant properties protects Langerhans islets against streptozotocin damage

Objective To design and synthesize an orcinol derivative compound, 3‐formyl‐2,4‐dihydroxy‐5,6‐dimethyl sodium benzoate (A4), as an antioxidant molecule and to test its effects on oxidative stress in an in‐vitro model of apoptosis of pancreatic rat beta cells induced by streptozotocin (STZ). Methods...

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Veröffentlicht in:	Journal of pharmacy and pharmacology 2017-03, Vol.69 (3), p.305-313
Hauptverfasser:	Sánchez‐Lira, Nancy M.V., Morales‐Miranda, Angélica, García de la Mora, Gustavo, León Contreras, Juan Carlos, González‐Sánchez, Ignacio, Valencia, Norma, Cerbón, Marco, Morimoto, Sumiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants Antioxidants - pharmacology Apoptosis Apoptosis - drug effects cellular morphology Insulin-Secreting Cells - drug effects Islets of Langerhans - drug effects Male Microscopy oxidative stress Oxidative Stress - drug effects pancreatic beta cells Protective Agents rat Rats Rats, Wistar Resorcinols - pharmacology Rodents Streptozocin - administration & dosage TUNEL
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