Combined ipsilateral limb use score as an index of motor deficits and neurorestoration in parkinsonian rats

Our aim was to apply a robust non‐drug induced sensorimotor test battery to assess the efficacy of neurorestorative therapies on the motor deficits caused by partial unilateral 6‐OHDA lesion mimicking early stage PD. Since the 6‐OHDA lesion protocols to induce partial DA depletion in striatum vary e...

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Veröffentlicht in:	Journal of neuroscience research 2017-09, Vol.95 (9), p.1858-1870
Hauptverfasser:	Leikas, Juuso V., Kääriäinen, Tiina M., Jalkanen, Aaro J., Lehtonen, Marko, Rantamäki, Tomi, Forsberg, Markus M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphetamines Animals Basal ganglia Behavior, Animal - drug effects Brain - drug effects Bundling Central nervous system diseases Cylinders Depletion dopamine Dopamine Antagonists - administration & dosage Dopamine Antagonists - toxicity Dose-Response Relationship, Drug exercise Forebrain High-performance liquid chromatography Laboratories Lesions Liquid chromatography Male Medial forebrain bundle Mimicry Motor Activity - drug effects motor deficit Motor Disorders - chemically induced Motor Disorders - etiology Motor task performance Movement disorders Neostriatum Neurodegenerative diseases Neuroprotection Oxidopamine - administration & dosage Oxidopamine - toxicity Parkinson's disease Parkinsonian Disorders - chemically induced Parkinsonian Disorders - complications partial 6‐OHDA lesion Physical training Rats Sensorimotor system sensorimotor test Variance analysis Vibrissae
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