Evolving spectrum of LRBA deficiency-associated chronic arthritis: is there a causative role in juvenile idiopathic arthritis?
Lipopolysaccharide-responsive, beige-like anchor protein (LRBA) deficiency causes common variable immunodeficiency (CVID) disorders and autoimmunity. LRBA deficiency has become a clinically variable syndrome with a wide spectrum of clinical manifestations. We report a patient with LRBA deficiency as...
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| Veröffentlicht in: | Clinical and experimental rheumatology 2017-03, Vol.35 (2), p.327-329 |
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| container_title | Clinical and experimental rheumatology |
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| creator | Al-Mayouf, Sulaiman M Naji, Hamzah Alismail, Khalid Alazami, Anas M Sheikh, Farrukh Conca, Walter Al-Mousa, Hamoud |
| description | Lipopolysaccharide-responsive, beige-like anchor protein (LRBA) deficiency causes common variable immunodeficiency (CVID) disorders and autoimmunity. LRBA deficiency has become a clinically variable syndrome with a wide spectrum of clinical manifestations. We report a patient with LRBA deficiency associated chronic non-erosive arthritis. This report highlights the spectrum of arthritis in such patients and the potential causative role of LRBA gene in juvenile arthritis. |
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LRBA deficiency has become a clinically variable syndrome with a wide spectrum of clinical manifestations. We report a patient with LRBA deficiency associated chronic non-erosive arthritis. 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LRBA deficiency has become a clinically variable syndrome with a wide spectrum of clinical manifestations. We report a patient with LRBA deficiency associated chronic non-erosive arthritis. 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LRBA deficiency has become a clinically variable syndrome with a wide spectrum of clinical manifestations. We report a patient with LRBA deficiency associated chronic non-erosive arthritis. This report highlights the spectrum of arthritis in such patients and the potential causative role of LRBA gene in juvenile arthritis.</abstract><cop>Italy</cop><pmid>28134088</pmid><tpages>3</tpages></addata></record> |
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| ispartof | Clinical and experimental rheumatology, 2017-03, Vol.35 (2), p.327-329 |
| issn | 0392-856X |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Abatacept - administration & dosage Adaptor Proteins, Signal Transducing - deficiency Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - immunology Adolescent Arthritis, Juvenile - diagnosis Arthritis, Juvenile - drug therapy Arthritis, Juvenile - genetics Arthritis, Juvenile - immunology Arthrography Chronic Disease Common Variable Immunodeficiency - diagnosis Common Variable Immunodeficiency - drug therapy Common Variable Immunodeficiency - genetics Common Variable Immunodeficiency - immunology DNA Mutational Analysis Genetic Predisposition to Disease Humans Immunosuppressive Agents - administration & dosage Knee Joint - diagnostic imaging Magnetic Resonance Imaging Male Mutation Phenotype Treatment Outcome |
| title | Evolving spectrum of LRBA deficiency-associated chronic arthritis: is there a causative role in juvenile idiopathic arthritis? |
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