Protective effects of timolol against the neuronal damage induced by glutamate and ischemia in the rat retina

The purpose of this study was to determine whether timolol, an ocular hypotensive drug, has retinal neuroprotective effects in experimental in vitro and in vivo models. For in vitro studies, we used retinal neuron cultures from rat embryos and purified retinal ganglion cells (RGCs) from newborn rats...

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Veröffentlicht in:	Brain research 2002-12, Vol.958 (1), p.10-19
Hauptverfasser:	Goto, Wakana, Ota, Takashi, Morikawa, Nobuo, Otori, Yasumasa, Hara, Hideaki, Kawazu, Kouichi, Miyawaki, Nobuaki, Tano, Yasuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Action Potentials - physiology Acute Disease Animals Biological and medical sciences Cell Death - drug effects Cell Death - physiology Cells, Cultured Disease Models, Animal Dose-Response Relationship, Drug Electroretinography Excitatory Amino Acid Antagonists - pharmacology Fetus Glaucoma - drug therapy Glaucoma - metabolism Glaucoma - physiopathology Glutamate Glutamic Acid - metabolism Glutamic Acid - toxicity Hypoxia-Ischemia, Brain - drug therapy Hypoxia-Ischemia, Brain - metabolism Hypoxia-Ischemia, Brain - physiopathology Ischemia Medical sciences Neuropharmacology Neuroprotection Neuroprotective agent Neuroprotective Agents - pharmacology Pharmacology. Drug treatments Rats Rats, Wistar Reperfusion Injury - drug therapy Reperfusion Injury - metabolism Reperfusion Injury - physiopathology Retina Retinal Degeneration - drug therapy Retinal Degeneration - metabolism Retinal Degeneration - physiopathology Retinal Ganglion Cells - drug effects Retinal Ganglion Cells - metabolism Retinal Ganglion Cells - pathology Timolol Timolol - pharmacology
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