Decidual arteriolopathy with or without associated hypertension modifies the underlying histomorphology in placentas from diabetic mothers
Aim The aim of this study was to retrospectively document the impact of hypertensive conditions in pregnancy and decidual arteriolopathy on the patterns of placental injury in maternal diabetes mellitus (MDM). Methods Among all 5248 > 20 weeks’ placentas, the frequencies of 19 selected clinical a...
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| Veröffentlicht in: | The journal of obstetrics and gynaecology research 2017-05, Vol.43 (5), p.839-847 |
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| container_title | The journal of obstetrics and gynaecology research |
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| creator | Stanek, Jerzy |
| description | Aim
The aim of this study was to retrospectively document the impact of hypertensive conditions in pregnancy and decidual arteriolopathy on the patterns of placental injury in maternal diabetes mellitus (MDM).
Methods
Among all 5248 > 20 weeks’ placentas, the frequencies of 19 selected clinical and 24 placental phenotypes were compared between 287 MDM placentas and 4961 remaining placentas (control group [CG]) before and after further exclusion of 85 and 611 patients with hypertensive conditions (gestational hypertension, pre‐eclampsia, chronic hypertension).
Results
Cesarean section rate, heavy placentas, decidual arteriolopathy, microscopic chorionic pseudocysts, and chorangiosis were more common in MDM than in the CG both before and after exclusion of hypertensive conditions. The frequencies of preuterine patterns of chronic hypoxic placental injury and plasma cell deciduitis became statistically significant only after exclusion of hypertensive conditions.
Conclusion
Hypertensive conditions of pregnancy may obscure the underlying preuterine placental hypoxic pattern in MDM placentas. Even in normotensive patients, decidual arteriolopathy, and shallow placental implantation significantly impact placental histomorphology in MDM. |
| doi_str_mv | 10.1111/jog.13276 |
| format | Article |
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The aim of this study was to retrospectively document the impact of hypertensive conditions in pregnancy and decidual arteriolopathy on the patterns of placental injury in maternal diabetes mellitus (MDM).
Methods
Among all 5248 > 20 weeks’ placentas, the frequencies of 19 selected clinical and 24 placental phenotypes were compared between 287 MDM placentas and 4961 remaining placentas (control group [CG]) before and after further exclusion of 85 and 611 patients with hypertensive conditions (gestational hypertension, pre‐eclampsia, chronic hypertension).
Results
Cesarean section rate, heavy placentas, decidual arteriolopathy, microscopic chorionic pseudocysts, and chorangiosis were more common in MDM than in the CG both before and after exclusion of hypertensive conditions. The frequencies of preuterine patterns of chronic hypoxic placental injury and plasma cell deciduitis became statistically significant only after exclusion of hypertensive conditions.
Conclusion
Hypertensive conditions of pregnancy may obscure the underlying preuterine placental hypoxic pattern in MDM placentas. Even in normotensive patients, decidual arteriolopathy, and shallow placental implantation significantly impact placental histomorphology in MDM.</description><identifier>ISSN: 1341-8076</identifier><identifier>EISSN: 1447-0756</identifier><identifier>DOI: 10.1111/jog.13276</identifier><identifier>PMID: 28127876</identifier><language>eng</language><publisher>Australia: Wiley Subscription Services, Inc</publisher><subject>Adult ; Arterioles - pathology ; Cesarean section ; Comorbidity ; Cysts ; Decidua ; Decidua - blood supply ; Diabetes mellitus ; Diabetes, Gestational - epidemiology ; Female ; Humans ; Hypertension ; Hypertension, Pregnancy-Induced - epidemiology ; Hypoxia ; Implantation ; maternal diabetes mellitus ; pathology ; Placenta ; Placenta Diseases - epidemiology ; Placenta Diseases - pathology ; Pre-eclampsia ; Preeclampsia ; Pregnancy ; Statistical analysis</subject><ispartof>The journal of obstetrics and gynaecology research, 2017-05, Vol.43 (5), p.839-847</ispartof><rights>2017 Japan Society of Obstetrics and Gynecology</rights><rights>2017 Japan Society of Obstetrics and Gynecology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3776-ec274ea135b9a5bd00d1ccff3ce2a7330eb609b4f258e02f0f6c05b568efe87c3</citedby><cites>FETCH-LOGICAL-c3776-ec274ea135b9a5bd00d1ccff3ce2a7330eb609b4f258e02f0f6c05b568efe87c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjog.13276$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjog.13276$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28127876$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stanek, Jerzy</creatorcontrib><title>Decidual arteriolopathy with or without associated hypertension modifies the underlying histomorphology in placentas from diabetic mothers</title><title>The journal of obstetrics and gynaecology research</title><addtitle>J Obstet Gynaecol Res</addtitle><description>Aim
The aim of this study was to retrospectively document the impact of hypertensive conditions in pregnancy and decidual arteriolopathy on the patterns of placental injury in maternal diabetes mellitus (MDM).
Methods
Among all 5248 > 20 weeks’ placentas, the frequencies of 19 selected clinical and 24 placental phenotypes were compared between 287 MDM placentas and 4961 remaining placentas (control group [CG]) before and after further exclusion of 85 and 611 patients with hypertensive conditions (gestational hypertension, pre‐eclampsia, chronic hypertension).
Results
Cesarean section rate, heavy placentas, decidual arteriolopathy, microscopic chorionic pseudocysts, and chorangiosis were more common in MDM than in the CG both before and after exclusion of hypertensive conditions. The frequencies of preuterine patterns of chronic hypoxic placental injury and plasma cell deciduitis became statistically significant only after exclusion of hypertensive conditions.
Conclusion
Hypertensive conditions of pregnancy may obscure the underlying preuterine placental hypoxic pattern in MDM placentas. Even in normotensive patients, decidual arteriolopathy, and shallow placental implantation significantly impact placental histomorphology in MDM.</description><subject>Adult</subject><subject>Arterioles - pathology</subject><subject>Cesarean section</subject><subject>Comorbidity</subject><subject>Cysts</subject><subject>Decidua</subject><subject>Decidua - blood supply</subject><subject>Diabetes mellitus</subject><subject>Diabetes, Gestational - epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension, Pregnancy-Induced - epidemiology</subject><subject>Hypoxia</subject><subject>Implantation</subject><subject>maternal diabetes mellitus</subject><subject>pathology</subject><subject>Placenta</subject><subject>Placenta Diseases - epidemiology</subject><subject>Placenta Diseases - pathology</subject><subject>Pre-eclampsia</subject><subject>Preeclampsia</subject><subject>Pregnancy</subject><subject>Statistical analysis</subject><issn>1341-8076</issn><issn>1447-0756</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kctO3TAQhi1ExX3BC1SW2MAiYMfx5SwR11ZIbNp15DjjEx8lcWo7QnkFnrouB1ggdTYzi28-jeZH6JSSS5rrauPXl5SVUuygA1pVsiCSi908s4oWikixjw5j3BBC5YqqPbRfKlpKJcUBer0F49pZ91iHBMH53k86dQt-canDPrx1PyesY_TG6QQt7pYJMjxG50c8-NZZBxGnDvA8thD6xY1r3LmY_ODD1GXlesFuxFOvDYxJR2yDH3DrdAPJmazIuyEeo29W9xFO3vsR-n1_9-vmsXh6fvhxc_1UGCalKMCUsgJNGW9WmjctIS01xlpmoNSSMQKNIKumsiVXQEpLrDCEN1wosKCkYUfofOudgv8zQ0z14KKBvtcj-DnWVIn8Si4Vz-jZF3Tj5zDm62q6KgmnlWI0UxdbygQfYwBbT8ENOiw1JfW_gPLWun4LKLPf341zM0D7SX4kkoGrLfDielj-b6p_Pj9slX8Bf1mehw</recordid><startdate>201705</startdate><enddate>201705</enddate><creator>Stanek, Jerzy</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TO</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201705</creationdate><title>Decidual arteriolopathy with or without associated hypertension modifies the underlying histomorphology in placentas from diabetic mothers</title><author>Stanek, Jerzy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3776-ec274ea135b9a5bd00d1ccff3ce2a7330eb609b4f258e02f0f6c05b568efe87c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Arterioles - pathology</topic><topic>Cesarean section</topic><topic>Comorbidity</topic><topic>Cysts</topic><topic>Decidua</topic><topic>Decidua - blood supply</topic><topic>Diabetes mellitus</topic><topic>Diabetes, Gestational - epidemiology</topic><topic>Female</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypertension, Pregnancy-Induced - epidemiology</topic><topic>Hypoxia</topic><topic>Implantation</topic><topic>maternal diabetes mellitus</topic><topic>pathology</topic><topic>Placenta</topic><topic>Placenta Diseases - epidemiology</topic><topic>Placenta Diseases - pathology</topic><topic>Pre-eclampsia</topic><topic>Preeclampsia</topic><topic>Pregnancy</topic><topic>Statistical analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stanek, Jerzy</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of obstetrics and gynaecology research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stanek, Jerzy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Decidual arteriolopathy with or without associated hypertension modifies the underlying histomorphology in placentas from diabetic mothers</atitle><jtitle>The journal of obstetrics and gynaecology research</jtitle><addtitle>J Obstet Gynaecol Res</addtitle><date>2017-05</date><risdate>2017</risdate><volume>43</volume><issue>5</issue><spage>839</spage><epage>847</epage><pages>839-847</pages><issn>1341-8076</issn><eissn>1447-0756</eissn><abstract>Aim
The aim of this study was to retrospectively document the impact of hypertensive conditions in pregnancy and decidual arteriolopathy on the patterns of placental injury in maternal diabetes mellitus (MDM).
Methods
Among all 5248 > 20 weeks’ placentas, the frequencies of 19 selected clinical and 24 placental phenotypes were compared between 287 MDM placentas and 4961 remaining placentas (control group [CG]) before and after further exclusion of 85 and 611 patients with hypertensive conditions (gestational hypertension, pre‐eclampsia, chronic hypertension).
Results
Cesarean section rate, heavy placentas, decidual arteriolopathy, microscopic chorionic pseudocysts, and chorangiosis were more common in MDM than in the CG both before and after exclusion of hypertensive conditions. The frequencies of preuterine patterns of chronic hypoxic placental injury and plasma cell deciduitis became statistically significant only after exclusion of hypertensive conditions.
Conclusion
Hypertensive conditions of pregnancy may obscure the underlying preuterine placental hypoxic pattern in MDM placentas. Even in normotensive patients, decidual arteriolopathy, and shallow placental implantation significantly impact placental histomorphology in MDM.</abstract><cop>Australia</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28127876</pmid><doi>10.1111/jog.13276</doi><tpages>9</tpages></addata></record> |
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| ispartof | The journal of obstetrics and gynaecology research, 2017-05, Vol.43 (5), p.839-847 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Arterioles - pathology Cesarean section Comorbidity Cysts Decidua Decidua - blood supply Diabetes mellitus Diabetes, Gestational - epidemiology Female Humans Hypertension Hypertension, Pregnancy-Induced - epidemiology Hypoxia Implantation maternal diabetes mellitus pathology Placenta Placenta Diseases - epidemiology Placenta Diseases - pathology Pre-eclampsia Preeclampsia Pregnancy Statistical analysis |
| title | Decidual arteriolopathy with or without associated hypertension modifies the underlying histomorphology in placentas from diabetic mothers |
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