Tumor suppressor gene methylation on the short arm of chromosome 1 in chronic myelogenous leukemia

Objectives We previously reported loss of heterozygosity on 1p in chronic myelogenous leukemia (CML). We analyzed promoter methylation and mutation of tumor suppressor genes on 1p36 in CML. Methods We performed methylation‐specific PCR (MS‐PCR) analysis of the PRDM2, RUNX3, and TP73 genes in 61 pati...

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Veröffentlicht in:	European journal of haematology 2017-05, Vol.98 (5), p.467-477
Hauptverfasser:	Mori, Naoki, Ohwashi‐Miyazaki, Mari, Yoshinaga, Kentaro, Okada, Michiko, Shiseki, Masayuki, Motoji, Toshiko, Tanaka, Junji
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Azacytidine Blast crisis Cell Line, Tumor Chromosome 1 Chromosomes, Human, Pair 1 Chronic myeloid leukemia Conformation Core Binding Factor Alpha 3 Subunit - genetics Demethylation DNA Methylation DNA-Binding Proteins - genetics Female Genes, Tumor Suppressor Genetic Predisposition to Disease Heterozygosity Histone-Lysine N-Methyltransferase - genetics Humans Karyotyping Leukemia Leukemia, Myelogenous, Chronic, BCR-ABL Positive - diagnosis Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics Loss of heterozygosity Male Middle Aged molecular cytogenetics Mutation Myeloid leukemia myeloproliferative neoplasms Neoplasm Staging Nuclear Proteins - genetics Polymerase Chain Reaction Promoter Regions, Genetic RNA-directed DNA polymerase Runx3 protein Sequence Analysis, DNA Transcription Factors - genetics Trichostatin A Tumor Protein p73 - genetics Tumor suppressor genes
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