Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibition Impairs Synaptic Plasticity via Seizure Protein 6

Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) is a promising drug target for the treatment of Alzheimer’s disease. Prolonged BACE1 inhibition interferes with structural and functional synaptic plasticity in mice, most likely by altering the metabolism of BACE1 substrates. Seizure pro...

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Veröffentlicht in:	Biological psychiatry (1969) 2018-03, Vol.83 (5), p.428-437
Hauptverfasser:	Zhu, Kaichuan, Xiang, Xianyuan, Filser, Severin, Marinković, Petar, Dorostkar, Mario M., Crux, Sophie, Neumann, Ulf, Shimshek, Derya R., Rammes, Gerhard, Haass, Christian, Lichtenthaler, Stefan F., Gunnersen, Jenny M., Herms, Jochen
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer’s disease BACE1 inhibition Dendritic spines In vivo two-photon imaging Long-term potentiation Sez6
Online-Zugang:	Volltext
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