Inflammatory potential of the diet and mortality in the Spanish cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC‐Spain)
Scope Low‐grade chronic inflammation is associated with several chronic conditions, and diet is known to play a role in chronic inflammation. We aimed to evaluate the association between the inflammatory potential of the diet and mortality in the Spanish population from the European Prospective Inve...
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| Veröffentlicht in: | Molecular nutrition & food research 2017-08, Vol.61 (8), p.n/a |
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| creator | Agudo, Antonio Masegú, Raquel Bonet, Catalina Jakszyn, Paula Quirós, J. Ramon Ardanaz, Eva Moreno‐Iribas, Conchi Barricarte, Aurelio Amiano, Pilar Arriola, Larraitz Chamosa, Saioa Dorronsoro, Miren Larrañaga, Nerea Navarro, Carmen Chirlaque, María‐Dolores Cirera, Lluís Gavrila, Diana Huerta, José‐María Rodríguez‐Barranco, Miguel Molina‐Portillo, Elena Sánchez, María‐José |
| description | Scope
Low‐grade chronic inflammation is associated with several chronic conditions, and diet is known to play a role in chronic inflammation. We aimed to evaluate the association between the inflammatory potential of the diet and mortality in the Spanish population from the European Prospective Investigation into Cancer and Nutrition (EPIC‐Spain).
Methods and results
The study included 41 199 participants (62% female) aged 29–69 years from five Spanish regions. During 18 years of follow‐up 3316 deaths were identified. The dietary inflammatory potential was assessed by means of an inflammatory score of the diet (ISD), calculated using 30 dietetic components and their corresponding inflammatory scores (weights). The association between the ISD and mortality was analyzed by multivariate Cox regression models. There was a significant association between ISD and mortality: subjects classified in the fifth quintile of the ISD (more proinflammatory diets) had a hazard ratio of 1.42 (95%‐confidence interval 1.25–1.60) as compared with those in the first quintile; the corresponding figures were 1.89 (1.48–2.40) for cardiovascular diseases mortality and 1.44 (1.22–1.69) for death by cancer.
Conclusion
Consuming more proinflammatory diets, expressed by means of the ISD, is associated with higher mortality; this effect seems to be stronger for deaths by cardiovascular diseases.
An inflammatory score is calculated to assess the inflammatory potential of the usual diet of about 41 000 Spanish adults. The study analyzes the impact on mortality of the inflammatory potential of diet together with body composition and physical activity. Inactive subjects with proinflammatory diets and abdominal obesity have 46% higher risk of death than nonobese and active subjects with more anti‐inflammatory diets. |
| doi_str_mv | 10.1002/mnfr.201600649 |
| format | Article |
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Low‐grade chronic inflammation is associated with several chronic conditions, and diet is known to play a role in chronic inflammation. We aimed to evaluate the association between the inflammatory potential of the diet and mortality in the Spanish population from the European Prospective Investigation into Cancer and Nutrition (EPIC‐Spain).
Methods and results
The study included 41 199 participants (62% female) aged 29–69 years from five Spanish regions. During 18 years of follow‐up 3316 deaths were identified. The dietary inflammatory potential was assessed by means of an inflammatory score of the diet (ISD), calculated using 30 dietetic components and their corresponding inflammatory scores (weights). The association between the ISD and mortality was analyzed by multivariate Cox regression models. There was a significant association between ISD and mortality: subjects classified in the fifth quintile of the ISD (more proinflammatory diets) had a hazard ratio of 1.42 (95%‐confidence interval 1.25–1.60) as compared with those in the first quintile; the corresponding figures were 1.89 (1.48–2.40) for cardiovascular diseases mortality and 1.44 (1.22–1.69) for death by cancer.
Conclusion
Consuming more proinflammatory diets, expressed by means of the ISD, is associated with higher mortality; this effect seems to be stronger for deaths by cardiovascular diseases.
An inflammatory score is calculated to assess the inflammatory potential of the usual diet of about 41 000 Spanish adults. The study analyzes the impact on mortality of the inflammatory potential of diet together with body composition and physical activity. Inactive subjects with proinflammatory diets and abdominal obesity have 46% higher risk of death than nonobese and active subjects with more anti‐inflammatory diets.</description><identifier>ISSN: 1613-4125</identifier><identifier>EISSN: 1613-4133</identifier><identifier>DOI: 10.1002/mnfr.201600649</identifier><identifier>PMID: 28130829</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Adult ; Aged ; Cancer ; Cardiovascular diseases ; Cardiovascular Diseases - etiology ; Cardiovascular Diseases - mortality ; Chronic conditions ; Chronic illnesses ; Chronic inflammation ; Cohort Studies ; Confidence intervals ; Diet ; Diet - adverse effects ; Energy Intake ; Fatalities ; Female ; Heart diseases ; Humans ; Indexing ; Inflammation ; Inflammation - etiology ; Inflammatory score of the diet ; Male ; Middle Aged ; Mortality ; Neoplasms - etiology ; Neoplasms - mortality ; Nutrition ; Proportional Hazards Models ; Prospective studies ; Quality ; Regression analysis ; Spain - epidemiology</subject><ispartof>Molecular nutrition & food research, 2017-08, Vol.61 (8), p.n/a</ispartof><rights>2017 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><rights>2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3687-42da50351048e59d7c25e354b408a8269ff41efacb522029a00eb12380f9d45b3</citedby><cites>FETCH-LOGICAL-c3687-42da50351048e59d7c25e354b408a8269ff41efacb522029a00eb12380f9d45b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmnfr.201600649$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmnfr.201600649$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28130829$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Agudo, Antonio</creatorcontrib><creatorcontrib>Masegú, Raquel</creatorcontrib><creatorcontrib>Bonet, Catalina</creatorcontrib><creatorcontrib>Jakszyn, Paula</creatorcontrib><creatorcontrib>Quirós, J. Ramon</creatorcontrib><creatorcontrib>Ardanaz, Eva</creatorcontrib><creatorcontrib>Moreno‐Iribas, Conchi</creatorcontrib><creatorcontrib>Barricarte, Aurelio</creatorcontrib><creatorcontrib>Amiano, Pilar</creatorcontrib><creatorcontrib>Arriola, Larraitz</creatorcontrib><creatorcontrib>Chamosa, Saioa</creatorcontrib><creatorcontrib>Dorronsoro, Miren</creatorcontrib><creatorcontrib>Larrañaga, Nerea</creatorcontrib><creatorcontrib>Navarro, Carmen</creatorcontrib><creatorcontrib>Chirlaque, María‐Dolores</creatorcontrib><creatorcontrib>Cirera, Lluís</creatorcontrib><creatorcontrib>Gavrila, Diana</creatorcontrib><creatorcontrib>Huerta, José‐María</creatorcontrib><creatorcontrib>Rodríguez‐Barranco, Miguel</creatorcontrib><creatorcontrib>Molina‐Portillo, Elena</creatorcontrib><creatorcontrib>Sánchez, María‐José</creatorcontrib><title>Inflammatory potential of the diet and mortality in the Spanish cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC‐Spain)</title><title>Molecular nutrition & food research</title><addtitle>Mol Nutr Food Res</addtitle><description>Scope
Low‐grade chronic inflammation is associated with several chronic conditions, and diet is known to play a role in chronic inflammation. We aimed to evaluate the association between the inflammatory potential of the diet and mortality in the Spanish population from the European Prospective Investigation into Cancer and Nutrition (EPIC‐Spain).
Methods and results
The study included 41 199 participants (62% female) aged 29–69 years from five Spanish regions. During 18 years of follow‐up 3316 deaths were identified. The dietary inflammatory potential was assessed by means of an inflammatory score of the diet (ISD), calculated using 30 dietetic components and their corresponding inflammatory scores (weights). The association between the ISD and mortality was analyzed by multivariate Cox regression models. There was a significant association between ISD and mortality: subjects classified in the fifth quintile of the ISD (more proinflammatory diets) had a hazard ratio of 1.42 (95%‐confidence interval 1.25–1.60) as compared with those in the first quintile; the corresponding figures were 1.89 (1.48–2.40) for cardiovascular diseases mortality and 1.44 (1.22–1.69) for death by cancer.
Conclusion
Consuming more proinflammatory diets, expressed by means of the ISD, is associated with higher mortality; this effect seems to be stronger for deaths by cardiovascular diseases.
An inflammatory score is calculated to assess the inflammatory potential of the usual diet of about 41 000 Spanish adults. The study analyzes the impact on mortality of the inflammatory potential of diet together with body composition and physical activity. Inactive subjects with proinflammatory diets and abdominal obesity have 46% higher risk of death than nonobese and active subjects with more anti‐inflammatory diets.</description><subject>Adult</subject><subject>Aged</subject><subject>Cancer</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Cardiovascular Diseases - mortality</subject><subject>Chronic conditions</subject><subject>Chronic illnesses</subject><subject>Chronic inflammation</subject><subject>Cohort Studies</subject><subject>Confidence intervals</subject><subject>Diet</subject><subject>Diet - adverse effects</subject><subject>Energy Intake</subject><subject>Fatalities</subject><subject>Female</subject><subject>Heart diseases</subject><subject>Humans</subject><subject>Indexing</subject><subject>Inflammation</subject><subject>Inflammation - etiology</subject><subject>Inflammatory score of the diet</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Neoplasms - etiology</subject><subject>Neoplasms - mortality</subject><subject>Nutrition</subject><subject>Proportional Hazards Models</subject><subject>Prospective studies</subject><subject>Quality</subject><subject>Regression analysis</subject><subject>Spain - epidemiology</subject><issn>1613-4125</issn><issn>1613-4133</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkbtuFDEUhi0EIhdoKZElmqTY5fgyXk-JVhtYKYSIS215ZmzW0Yw92J5E2_EItLweT4Kzm2xBQ2VL_3c-HZ0foVcE5gSAvh28jXMKRAAIXj9Bx0QQNuOEsaeHP62O0ElKNwCMUM6eoyMqCQNJ62P0e-1tr4dB5xC3eAzZ-Ox0j4PFeWNw50zG2nd4CDHr3uUtdn6XfBm1d2mD27Ap0SO_mmIYjfb4OoY0mja7W4PX_tak7L7r7IIv8zngpfatiTvz1ZSj2yVnq-v18s_PX0Xt_PkL9MzqPpmXD-8p-nax-rr8MLv89H69fHc5a5mQixmnna6AVQS4NFXdLVpaGVbxhoPUkoraWk6M1W1TUQq01gCmIZRJsHXHq4adorO9d4zhx1QWVYNLrel77U2YkiJS0IUARmlB3_yD3oQp-rKdIjWtmSwnFYWa76m23CBFY9UY3aDjVhFQ96Wp-9LUobQy8PpBOzWD6Q74Y0sF4HvgzvVm-x-d-nh18ZlKsWB_AYMppGE</recordid><startdate>201708</startdate><enddate>201708</enddate><creator>Agudo, Antonio</creator><creator>Masegú, Raquel</creator><creator>Bonet, Catalina</creator><creator>Jakszyn, Paula</creator><creator>Quirós, J. Ramon</creator><creator>Ardanaz, Eva</creator><creator>Moreno‐Iribas, Conchi</creator><creator>Barricarte, Aurelio</creator><creator>Amiano, Pilar</creator><creator>Arriola, Larraitz</creator><creator>Chamosa, Saioa</creator><creator>Dorronsoro, Miren</creator><creator>Larrañaga, Nerea</creator><creator>Navarro, Carmen</creator><creator>Chirlaque, María‐Dolores</creator><creator>Cirera, Lluís</creator><creator>Gavrila, Diana</creator><creator>Huerta, José‐María</creator><creator>Rodríguez‐Barranco, Miguel</creator><creator>Molina‐Portillo, Elena</creator><creator>Sánchez, María‐José</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201708</creationdate><title>Inflammatory potential of the diet and mortality in the Spanish cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC‐Spain)</title><author>Agudo, Antonio ; Masegú, Raquel ; Bonet, Catalina ; Jakszyn, Paula ; Quirós, J. Ramon ; Ardanaz, Eva ; Moreno‐Iribas, Conchi ; Barricarte, Aurelio ; Amiano, Pilar ; Arriola, Larraitz ; Chamosa, Saioa ; Dorronsoro, Miren ; Larrañaga, Nerea ; Navarro, Carmen ; Chirlaque, María‐Dolores ; Cirera, Lluís ; Gavrila, Diana ; Huerta, José‐María ; Rodríguez‐Barranco, Miguel ; Molina‐Portillo, Elena ; Sánchez, María‐José</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3687-42da50351048e59d7c25e354b408a8269ff41efacb522029a00eb12380f9d45b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Cancer</topic><topic>Cardiovascular diseases</topic><topic>Cardiovascular Diseases - etiology</topic><topic>Cardiovascular Diseases - mortality</topic><topic>Chronic conditions</topic><topic>Chronic illnesses</topic><topic>Chronic inflammation</topic><topic>Cohort Studies</topic><topic>Confidence intervals</topic><topic>Diet</topic><topic>Diet - adverse effects</topic><topic>Energy Intake</topic><topic>Fatalities</topic><topic>Female</topic><topic>Heart diseases</topic><topic>Humans</topic><topic>Indexing</topic><topic>Inflammation</topic><topic>Inflammation - etiology</topic><topic>Inflammatory score of the diet</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Neoplasms - etiology</topic><topic>Neoplasms - mortality</topic><topic>Nutrition</topic><topic>Proportional Hazards Models</topic><topic>Prospective studies</topic><topic>Quality</topic><topic>Regression analysis</topic><topic>Spain - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Agudo, Antonio</creatorcontrib><creatorcontrib>Masegú, Raquel</creatorcontrib><creatorcontrib>Bonet, Catalina</creatorcontrib><creatorcontrib>Jakszyn, Paula</creatorcontrib><creatorcontrib>Quirós, J. Ramon</creatorcontrib><creatorcontrib>Ardanaz, Eva</creatorcontrib><creatorcontrib>Moreno‐Iribas, Conchi</creatorcontrib><creatorcontrib>Barricarte, Aurelio</creatorcontrib><creatorcontrib>Amiano, Pilar</creatorcontrib><creatorcontrib>Arriola, Larraitz</creatorcontrib><creatorcontrib>Chamosa, Saioa</creatorcontrib><creatorcontrib>Dorronsoro, Miren</creatorcontrib><creatorcontrib>Larrañaga, Nerea</creatorcontrib><creatorcontrib>Navarro, Carmen</creatorcontrib><creatorcontrib>Chirlaque, María‐Dolores</creatorcontrib><creatorcontrib>Cirera, Lluís</creatorcontrib><creatorcontrib>Gavrila, Diana</creatorcontrib><creatorcontrib>Huerta, José‐María</creatorcontrib><creatorcontrib>Rodríguez‐Barranco, Miguel</creatorcontrib><creatorcontrib>Molina‐Portillo, Elena</creatorcontrib><creatorcontrib>Sánchez, María‐José</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular nutrition & food research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Agudo, Antonio</au><au>Masegú, Raquel</au><au>Bonet, Catalina</au><au>Jakszyn, Paula</au><au>Quirós, J. Ramon</au><au>Ardanaz, Eva</au><au>Moreno‐Iribas, Conchi</au><au>Barricarte, Aurelio</au><au>Amiano, Pilar</au><au>Arriola, Larraitz</au><au>Chamosa, Saioa</au><au>Dorronsoro, Miren</au><au>Larrañaga, Nerea</au><au>Navarro, Carmen</au><au>Chirlaque, María‐Dolores</au><au>Cirera, Lluís</au><au>Gavrila, Diana</au><au>Huerta, José‐María</au><au>Rodríguez‐Barranco, Miguel</au><au>Molina‐Portillo, Elena</au><au>Sánchez, María‐José</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inflammatory potential of the diet and mortality in the Spanish cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC‐Spain)</atitle><jtitle>Molecular nutrition & food research</jtitle><addtitle>Mol Nutr Food Res</addtitle><date>2017-08</date><risdate>2017</risdate><volume>61</volume><issue>8</issue><epage>n/a</epage><issn>1613-4125</issn><eissn>1613-4133</eissn><abstract>Scope
Low‐grade chronic inflammation is associated with several chronic conditions, and diet is known to play a role in chronic inflammation. We aimed to evaluate the association between the inflammatory potential of the diet and mortality in the Spanish population from the European Prospective Investigation into Cancer and Nutrition (EPIC‐Spain).
Methods and results
The study included 41 199 participants (62% female) aged 29–69 years from five Spanish regions. During 18 years of follow‐up 3316 deaths were identified. The dietary inflammatory potential was assessed by means of an inflammatory score of the diet (ISD), calculated using 30 dietetic components and their corresponding inflammatory scores (weights). The association between the ISD and mortality was analyzed by multivariate Cox regression models. There was a significant association between ISD and mortality: subjects classified in the fifth quintile of the ISD (more proinflammatory diets) had a hazard ratio of 1.42 (95%‐confidence interval 1.25–1.60) as compared with those in the first quintile; the corresponding figures were 1.89 (1.48–2.40) for cardiovascular diseases mortality and 1.44 (1.22–1.69) for death by cancer.
Conclusion
Consuming more proinflammatory diets, expressed by means of the ISD, is associated with higher mortality; this effect seems to be stronger for deaths by cardiovascular diseases.
An inflammatory score is calculated to assess the inflammatory potential of the usual diet of about 41 000 Spanish adults. The study analyzes the impact on mortality of the inflammatory potential of diet together with body composition and physical activity. Inactive subjects with proinflammatory diets and abdominal obesity have 46% higher risk of death than nonobese and active subjects with more anti‐inflammatory diets.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28130829</pmid><doi>10.1002/mnfr.201600649</doi><tpages>11</tpages></addata></record> |
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| ispartof | Molecular nutrition & food research, 2017-08, Vol.61 (8), p.n/a |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Aged Cancer Cardiovascular diseases Cardiovascular Diseases - etiology Cardiovascular Diseases - mortality Chronic conditions Chronic illnesses Chronic inflammation Cohort Studies Confidence intervals Diet Diet - adverse effects Energy Intake Fatalities Female Heart diseases Humans Indexing Inflammation Inflammation - etiology Inflammatory score of the diet Male Middle Aged Mortality Neoplasms - etiology Neoplasms - mortality Nutrition Proportional Hazards Models Prospective studies Quality Regression analysis Spain - epidemiology |
| title | Inflammatory potential of the diet and mortality in the Spanish cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC‐Spain) |
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