A Branched Peptide Mimotope of the Nicotinic Receptor Binding Site Is a Potent Synthetic Antidote against the Snake Neurotoxin α-Bungarotoxin

We previously produced synthetic peptides mimicking the snake neurotoxin binding site of the nicotinic receptor. These peptide mimotopes bind the snake neurotoxin α-bungarotoxin with higher affinity than peptides reproducing native receptor sequences and inhibit toxin binding to nicotinic receptors...

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Veröffentlicht in:	Biochemistry (Easton) 2002-08, Vol.41 (32), p.10194-10199
Hauptverfasser:	Bracci, Luisa, Lozzi, Luisa, Pini, Alessandro, Lelli, Barbara, Falciani, Chiara, Niccolai, Neri, Bernini, Andrea, Spreafico, Adriano, Soldani, Patrizia, Neri, Paolo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antidotes - administration & dosage Antidotes - chemical synthesis Antidotes - metabolism Antidotes - pharmacology Binding Sites Binding, Competitive Bungarotoxins - antagonists & inhibitors Bungarotoxins - toxicity Epitopes - administration & dosage Epitopes - chemistry Epitopes - metabolism Epitopes - pharmacology Injections, Subcutaneous Lethal Dose 50 Ligands Mice Molecular Mimicry Peptide Fragments - administration & dosage Peptide Fragments - chemical synthesis Peptide Fragments - metabolism Peptide Fragments - pharmacology Receptors, Nicotinic - metabolism
Online-Zugang:	Volltext
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