The Zinc- and Calcium-binding S100B Interacts and Co-localizes with IQGAP1 during Dynamic Rearrangement of Cell Membranes

The Zn2+- and Ca2+-binding S100B protein is implicated in multiple intracellular and extracellular regulatory events. In glial cells, a relationship exists between cytoplasmic S100B accumulation and cell morphological changes. We have identified the IQGAP1 protein as the major cytoplasmic S100B targ...

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Veröffentlicht in:	The Journal of biological chemistry 2002-12, Vol.277 (51), p.49998-50007
Hauptverfasser:	Mbele, Gaelh Ouengue, Deloulme, Jean Christophe, Gentil, Benoı̂t Jean, Delphin, Christian, Ferro, Myriam, Garin, Jérôme, Takahashi, Miyoko, Baudier, Jacques
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Amino Acid Motifs Animals Astrocytoma - metabolism Binding Sites Blotting, Western Calcium - metabolism Carrier Proteins - biosynthesis Carrier Proteins - chemistry Cell Membrane - metabolism Cytoplasm - metabolism Dose-Response Relationship, Drug Humans Mass Spectrometry Mice Microscopy, Confocal Microscopy, Fluorescence Nerve Growth Factors - chemistry Nerve Growth Factors - metabolism Plasmids - metabolism Precipitin Tests Protein Binding Protein Structure, Tertiary ras GTPase-Activating Proteins Rats S100 Calcium Binding Protein beta Subunit S100 Proteins - chemistry S100 Proteins - metabolism Time Factors Transfection Tumor Cells, Cultured Zinc - metabolism
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