Pregnancy outcome after cabergoline treatment in early weeks of gestation
We collected information on 61 pregnancies in 50 women treated with cabergoline. These pregnancies resulted in 12 (19.7%) early terminations (five induced abortions, six spontaneous abortions, one hydatidiform mole) and 49 (80.3%) live births. In one case, malformations were suspected by a gynecolog...
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| Veröffentlicht in: | Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2002-11, Vol.16 (6), p.791-793 |
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| container_title | Reproductive toxicology (Elmsford, N.Y.) |
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| creator | Ricci, Elena Parazzini, Fabio Motta, Tiziano Ferrari, Carlo I Colao, Annamaria Clavenna, Antonio Rocchi, Francesca Gangi, Emanuela Paracchi, Sandra Gasperi, Maurizio Lavezzari, Maurizio Nicolosi, Anna Elisa Ferrero, Simona Landi, Maria Luisa Beck-Peccoz, Paolo Bonati, Maurizio |
| description | We collected information on 61 pregnancies in 50 women treated with cabergoline. These pregnancies resulted in 12 (19.7%) early terminations (five induced abortions, six spontaneous abortions, one hydatidiform mole) and 49 (80.3%) live births. In one case, malformations were suspected by a gynecologist based on ultrasound at 12 gestational weeks and the pregnancy was terminated; additional information was not available. There was one case of trisomy 18. The frequency of spontaneous and induced abortions and major congenital malformations was comparable with rates in the general population. The data did not indicate any potential adverse effect of the drug on pregnancy. The data from this study in combination with previous reports can exclude a congenital malformation risk greater than 10% associated with pregnancy exposure to cabergoline. |
| doi_str_mv | 10.1016/S0890-6238(02)00055-2 |
| format | Article |
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These pregnancies resulted in 12 (19.7%) early terminations (five induced abortions, six spontaneous abortions, one hydatidiform mole) and 49 (80.3%) live births. In one case, malformations were suspected by a gynecologist based on ultrasound at 12 gestational weeks and the pregnancy was terminated; additional information was not available. There was one case of trisomy 18. The frequency of spontaneous and induced abortions and major congenital malformations was comparable with rates in the general population. The data did not indicate any potential adverse effect of the drug on pregnancy. The data from this study in combination with previous reports can exclude a congenital malformation risk greater than 10% associated with pregnancy exposure to cabergoline.</description><identifier>ISSN: 0890-6238</identifier><identifier>EISSN: 1873-1708</identifier><identifier>DOI: 10.1016/S0890-6238(02)00055-2</identifier><identifier>PMID: 12401507</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Abnormalities, Drug-Induced - epidemiology ; Abnormalities, Drug-Induced - etiology ; Abortion, Spontaneous - epidemiology ; Adult ; Biological and medical sciences ; Cabergoline ; Dopamine Agonists - therapeutic use ; Drug adverse effects ; Drug toxicity and drugs side effects treatment ; Embryology: invertebrates and vertebrates. Teratology ; Ergolines - therapeutic use ; Female ; Fundamental and applied biological sciences. Psychology ; Gestational Age ; Humans ; Italy - epidemiology ; Medical sciences ; Miscellaneous (drug allergy, mutagens, teratogens...) ; Newborn ; Pharmacology. Drug treatments ; Pregnancy ; Pregnancy Outcome ; Prospective Studies ; Teratology. 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These pregnancies resulted in 12 (19.7%) early terminations (five induced abortions, six spontaneous abortions, one hydatidiform mole) and 49 (80.3%) live births. In one case, malformations were suspected by a gynecologist based on ultrasound at 12 gestational weeks and the pregnancy was terminated; additional information was not available. There was one case of trisomy 18. The frequency of spontaneous and induced abortions and major congenital malformations was comparable with rates in the general population. The data did not indicate any potential adverse effect of the drug on pregnancy. The data from this study in combination with previous reports can exclude a congenital malformation risk greater than 10% associated with pregnancy exposure to cabergoline.</description><subject>Abnormalities, Drug-Induced - epidemiology</subject><subject>Abnormalities, Drug-Induced - etiology</subject><subject>Abortion, Spontaneous - epidemiology</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cabergoline</subject><subject>Dopamine Agonists - therapeutic use</subject><subject>Drug adverse effects</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Embryology: invertebrates and vertebrates. Teratology</subject><subject>Ergolines - therapeutic use</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>Italy - epidemiology</subject><subject>Medical sciences</subject><subject>Miscellaneous (drug allergy, mutagens, teratogens...)</subject><subject>Newborn</subject><subject>Pharmacology. Drug treatments</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome</subject><subject>Prospective Studies</subject><subject>Teratology. 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Teratology</topic><topic>Ergolines - therapeutic use</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gestational Age</topic><topic>Humans</topic><topic>Italy - epidemiology</topic><topic>Medical sciences</topic><topic>Miscellaneous (drug allergy, mutagens, teratogens...)</topic><topic>Newborn</topic><topic>Pharmacology. Drug treatments</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome</topic><topic>Prospective Studies</topic><topic>Teratology. 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| fulltext | fulltext |
| identifier | ISSN: 0890-6238 |
| ispartof | Reproductive toxicology (Elmsford, N.Y.), 2002-11, Vol.16 (6), p.791-793 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Abnormalities, Drug-Induced - epidemiology Abnormalities, Drug-Induced - etiology Abortion, Spontaneous - epidemiology Adult Biological and medical sciences Cabergoline Dopamine Agonists - therapeutic use Drug adverse effects Drug toxicity and drugs side effects treatment Embryology: invertebrates and vertebrates. Teratology Ergolines - therapeutic use Female Fundamental and applied biological sciences. Psychology Gestational Age Humans Italy - epidemiology Medical sciences Miscellaneous (drug allergy, mutagens, teratogens...) Newborn Pharmacology. Drug treatments Pregnancy Pregnancy Outcome Prospective Studies Teratology. Teratogens |
| title | Pregnancy outcome after cabergoline treatment in early weeks of gestation |
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