Magnesium prevents phosphate-induced vascular calcification via TRPM7 and Pit-1 in an aortic tissue culture model

Previous clinical and experimental studies have indicated that magnesium may prevent vascular calcification (VC), but mechanistic characterization has not been reported. This study investigated the influence of increasing magnesium concentrations on VC in a rat aortic tissue culture model. Aortic se...

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Veröffentlicht in:	Hypertension research 2017-06, Vol.40 (6), p.562-567
Hauptverfasser:	Sonou, Tomohiro, Ohya, Masaki, Yashiro, Mitsuru, Masumoto, Asuka, Nakashima, Yuri, Ito, Teppei, Mima, Toru, Negi, Shigeo, Kimura-Suda, Hiromi, Shigematsu, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta Calcification Hypertension Magnesium - pharmacology Magnesium - therapeutic use Male Microscopy, Electron, Scanning Phosphates Rats, Sprague-Dawley Rodents Scanning electron microscopy Sodium-Phosphate Cotransporter Proteins, Type III - metabolism Spectrometry, X-Ray Emission Spectroscopy, Fourier Transform Infrared Spectrum analysis Tissue Culture Techniques TRPM Cation Channels - metabolism Vascular Calcification - prevention & control
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