Associations of prenatal and childhood antibiotic use with child body mass index at age 3 years
Objective Early‐life antibiotic exposure, whether through prenatal or childhood antibiotic use, may contribute to increased child body mass. Associations of prenatal and childhood antibiotic use with body mass index z‐score (BMIz) were evaluated at age 3 years. Methods Electronic health records were...
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| Veröffentlicht in: | Obesity (Silver Spring, Md.) Md.), 2017-02, Vol.25 (2), p.438-444 |
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| creator | Poulsen, Melissa N. Pollak, Jonathan Bailey‐Davis, Lisa Hirsch, Annemarie G. Glass, Thomas A. Schwartz, Brian S. |
| description | Objective
Early‐life antibiotic exposure, whether through prenatal or childhood antibiotic use, may contribute to increased child body mass. Associations of prenatal and childhood antibiotic use with body mass index z‐score (BMIz) were evaluated at age 3 years.
Methods
Electronic health records were utilized from 8,793 mothers and singleton children delivered at Geisinger Clinic in Pennsylvania between 2006 and 2012. Antibiotic orders were ascertained for mothers during pregnancy and for children through their age‐3 BMI measurement. Linear mixed‐effects regression models evaluated associations of prenatal and childhood antibiotic use with child BMIz.
Results
Prenatal antibiotic orders were not associated with child BMIz. Children in the three largest categories of lifetime antibiotic orders had higher BMIz compared with children with no orders; associations persisted when controlling for prenatal antibiotics (β [95% confidence interval]) (4‐5 child orders: 0.090 [0.011 to 0.170]; 6 to 8: 0.113 [0.029 to 0.197]; ≥9: 0.175 [0.088 to 0.263]; trend P value |
| doi_str_mv | 10.1002/oby.21719 |
| format | Article |
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Early‐life antibiotic exposure, whether through prenatal or childhood antibiotic use, may contribute to increased child body mass. Associations of prenatal and childhood antibiotic use with body mass index z‐score (BMIz) were evaluated at age 3 years.
Methods
Electronic health records were utilized from 8,793 mothers and singleton children delivered at Geisinger Clinic in Pennsylvania between 2006 and 2012. Antibiotic orders were ascertained for mothers during pregnancy and for children through their age‐3 BMI measurement. Linear mixed‐effects regression models evaluated associations of prenatal and childhood antibiotic use with child BMIz.
Results
Prenatal antibiotic orders were not associated with child BMIz. Children in the three largest categories of lifetime antibiotic orders had higher BMIz compared with children with no orders; associations persisted when controlling for prenatal antibiotics (β [95% confidence interval]) (4‐5 child orders: 0.090 [0.011 to 0.170]; 6 to 8: 0.113 [0.029 to 0.197]; ≥9: 0.175 [0.088 to 0.263]; trend P value <0.001). Two or more first‐year orders were also associated with BMIz (1: 0.021 [−0.038 to 0.081]; 2: 0.088 [0.017 to 0.160]; ≥3: 0.104 [0.038 to 0.170]; trend P value < 0.001).
Conclusions
Associations of early‐life and lifetime childhood antibiotic use with increased child BMI highlight antibiotic exposure as a modifiable factor for reducing population‐level excess weight.</description><identifier>ISSN: 1930-7381</identifier><identifier>EISSN: 1930-739X</identifier><identifier>DOI: 10.1002/oby.21719</identifier><identifier>PMID: 28124504</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Age ; Anti-Bacterial Agents - pharmacology ; Anti-Bacterial Agents - therapeutic use ; Antibiotics ; Birth weight ; Body Mass Index ; Body Weight - drug effects ; Child, Preschool ; Children & youth ; Female ; Generic products ; Humans ; Infections ; Male ; Metabolism ; Obesity ; Pennsylvania ; Population ; Pregnancy ; Prenatal Exposure Delayed Effects - physiopathology ; Studies ; Time Factors</subject><ispartof>Obesity (Silver Spring, Md.), 2017-02, Vol.25 (2), p.438-444</ispartof><rights>2017 The Obesity Society</rights><rights>2017 The Obesity Society.</rights><rights>Copyright Blackwell Publishing Ltd. Feb 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3889-aef83e09da4549b193cbc7f496304b11cfdc65f86715f86c0417e213f0588d6b3</citedby><cites>FETCH-LOGICAL-c3889-aef83e09da4549b193cbc7f496304b11cfdc65f86715f86c0417e213f0588d6b3</cites><orcidid>0000-0002-5915-371X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Foby.21719$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Foby.21719$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28124504$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Poulsen, Melissa N.</creatorcontrib><creatorcontrib>Pollak, Jonathan</creatorcontrib><creatorcontrib>Bailey‐Davis, Lisa</creatorcontrib><creatorcontrib>Hirsch, Annemarie G.</creatorcontrib><creatorcontrib>Glass, Thomas A.</creatorcontrib><creatorcontrib>Schwartz, Brian S.</creatorcontrib><title>Associations of prenatal and childhood antibiotic use with child body mass index at age 3 years</title><title>Obesity (Silver Spring, Md.)</title><addtitle>Obesity (Silver Spring)</addtitle><description>Objective
Early‐life antibiotic exposure, whether through prenatal or childhood antibiotic use, may contribute to increased child body mass. Associations of prenatal and childhood antibiotic use with body mass index z‐score (BMIz) were evaluated at age 3 years.
Methods
Electronic health records were utilized from 8,793 mothers and singleton children delivered at Geisinger Clinic in Pennsylvania between 2006 and 2012. Antibiotic orders were ascertained for mothers during pregnancy and for children through their age‐3 BMI measurement. Linear mixed‐effects regression models evaluated associations of prenatal and childhood antibiotic use with child BMIz.
Results
Prenatal antibiotic orders were not associated with child BMIz. Children in the three largest categories of lifetime antibiotic orders had higher BMIz compared with children with no orders; associations persisted when controlling for prenatal antibiotics (β [95% confidence interval]) (4‐5 child orders: 0.090 [0.011 to 0.170]; 6 to 8: 0.113 [0.029 to 0.197]; ≥9: 0.175 [0.088 to 0.263]; trend P value <0.001). Two or more first‐year orders were also associated with BMIz (1: 0.021 [−0.038 to 0.081]; 2: 0.088 [0.017 to 0.160]; ≥3: 0.104 [0.038 to 0.170]; trend P value < 0.001).
Conclusions
Associations of early‐life and lifetime childhood antibiotic use with increased child BMI highlight antibiotic exposure as a modifiable factor for reducing population‐level excess weight.</description><subject>Age</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Antibiotics</subject><subject>Birth weight</subject><subject>Body Mass Index</subject><subject>Body Weight - drug effects</subject><subject>Child, Preschool</subject><subject>Children & youth</subject><subject>Female</subject><subject>Generic products</subject><subject>Humans</subject><subject>Infections</subject><subject>Male</subject><subject>Metabolism</subject><subject>Obesity</subject><subject>Pennsylvania</subject><subject>Population</subject><subject>Pregnancy</subject><subject>Prenatal Exposure Delayed Effects - physiopathology</subject><subject>Studies</subject><subject>Time Factors</subject><issn>1930-7381</issn><issn>1930-739X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10E9LwzAYBvAgipvTg19AAl700C1vk7bpcQ7_wWAXBT2FNEldRtfMpmX229vZuYPgJclLfjy8PAhdAhkDIeHEZe04hATSIzSElJIgoenb8eHNYYDOvF8RwmISwSkahBxCFhE2RGLqvVNW1taVHrscbypTyloWWJYaq6Ut9NI53U21zayrrcKNN3hr62X_izOnW7yW3mNbavOFZY3lh8EUt0ZW_hyd5LLw5mJ_j9Drw_3L7CmYLx6fZ9N5oCjnaSBNzqkhqZYsYmnWLa4yleQsjSlhGYDKtYqjnMcJ7E5FGCQmBJqTiHMdZ3SEbvrcTeU-G-NrsbZemaKQpXGNF8DjMORhBKyj13_oyjVV2W23UzSKAUjcqdteqcp5X5lcbCq7llUrgIhd66JrXfy03tmrfWKTrY0-yN-aOzDpwdYWpv0_SSzu3vvIb4Ogiqw</recordid><startdate>201702</startdate><enddate>201702</enddate><creator>Poulsen, Melissa N.</creator><creator>Pollak, Jonathan</creator><creator>Bailey‐Davis, Lisa</creator><creator>Hirsch, Annemarie G.</creator><creator>Glass, Thomas A.</creator><creator>Schwartz, Brian S.</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5915-371X</orcidid></search><sort><creationdate>201702</creationdate><title>Associations of prenatal and childhood antibiotic use with child body mass index at age 3 years</title><author>Poulsen, Melissa N. ; Pollak, Jonathan ; Bailey‐Davis, Lisa ; Hirsch, Annemarie G. ; Glass, Thomas A. ; Schwartz, Brian S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3889-aef83e09da4549b193cbc7f496304b11cfdc65f86715f86c0417e213f0588d6b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Age</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Antibiotics</topic><topic>Birth weight</topic><topic>Body Mass Index</topic><topic>Body Weight - drug effects</topic><topic>Child, Preschool</topic><topic>Children & youth</topic><topic>Female</topic><topic>Generic products</topic><topic>Humans</topic><topic>Infections</topic><topic>Male</topic><topic>Metabolism</topic><topic>Obesity</topic><topic>Pennsylvania</topic><topic>Population</topic><topic>Pregnancy</topic><topic>Prenatal Exposure Delayed Effects - physiopathology</topic><topic>Studies</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Poulsen, Melissa N.</creatorcontrib><creatorcontrib>Pollak, Jonathan</creatorcontrib><creatorcontrib>Bailey‐Davis, Lisa</creatorcontrib><creatorcontrib>Hirsch, Annemarie G.</creatorcontrib><creatorcontrib>Glass, Thomas A.</creatorcontrib><creatorcontrib>Schwartz, Brian S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Obesity (Silver Spring, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Poulsen, Melissa N.</au><au>Pollak, Jonathan</au><au>Bailey‐Davis, Lisa</au><au>Hirsch, Annemarie G.</au><au>Glass, Thomas A.</au><au>Schwartz, Brian S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Associations of prenatal and childhood antibiotic use with child body mass index at age 3 years</atitle><jtitle>Obesity (Silver Spring, Md.)</jtitle><addtitle>Obesity (Silver Spring)</addtitle><date>2017-02</date><risdate>2017</risdate><volume>25</volume><issue>2</issue><spage>438</spage><epage>444</epage><pages>438-444</pages><issn>1930-7381</issn><eissn>1930-739X</eissn><abstract>Objective
Early‐life antibiotic exposure, whether through prenatal or childhood antibiotic use, may contribute to increased child body mass. Associations of prenatal and childhood antibiotic use with body mass index z‐score (BMIz) were evaluated at age 3 years.
Methods
Electronic health records were utilized from 8,793 mothers and singleton children delivered at Geisinger Clinic in Pennsylvania between 2006 and 2012. Antibiotic orders were ascertained for mothers during pregnancy and for children through their age‐3 BMI measurement. Linear mixed‐effects regression models evaluated associations of prenatal and childhood antibiotic use with child BMIz.
Results
Prenatal antibiotic orders were not associated with child BMIz. Children in the three largest categories of lifetime antibiotic orders had higher BMIz compared with children with no orders; associations persisted when controlling for prenatal antibiotics (β [95% confidence interval]) (4‐5 child orders: 0.090 [0.011 to 0.170]; 6 to 8: 0.113 [0.029 to 0.197]; ≥9: 0.175 [0.088 to 0.263]; trend P value <0.001). Two or more first‐year orders were also associated with BMIz (1: 0.021 [−0.038 to 0.081]; 2: 0.088 [0.017 to 0.160]; ≥3: 0.104 [0.038 to 0.170]; trend P value < 0.001).
Conclusions
Associations of early‐life and lifetime childhood antibiotic use with increased child BMI highlight antibiotic exposure as a modifiable factor for reducing population‐level excess weight.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>28124504</pmid><doi>10.1002/oby.21719</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-5915-371X</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Obesity (Silver Spring, Md.), 2017-02, Vol.25 (2), p.438-444 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Wiley Online Library Free Content |
| subjects | Age Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Antibiotics Birth weight Body Mass Index Body Weight - drug effects Child, Preschool Children & youth Female Generic products Humans Infections Male Metabolism Obesity Pennsylvania Population Pregnancy Prenatal Exposure Delayed Effects - physiopathology Studies Time Factors |
| title | Associations of prenatal and childhood antibiotic use with child body mass index at age 3 years |
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