Effects of Combined Treatment with Branched-Chain Amino Acids, Citric Acid, L-Carnitine, Coenzyme Q10, Zinc, and Various Vitamins in Tumor-Bearing Mice
A functional dietary supplement (FDS) containing Coenzyme Q10, branched-chain amino acids and L-carnitine was administered to tumor-bearing mice, investigating its effects on tumor and muscle tissues. Experiment (A): B16 melanoma cells were implanted subcutaneously into the right side of the abdomen...
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| Veröffentlicht in: | Biological & pharmaceutical bulletin 2017/03/01, Vol.40(3), pp.266-271 |
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| creator | Awa, Hiroko Futamura, Akihiko Higashiguchi, Takashi Ito, Akihiro Mori, Naoharu Murai, Miyo Ohara, Hiroshi Chihara, Takeshi Kaneko, Takaaki |
| description | A functional dietary supplement (FDS) containing Coenzyme Q10, branched-chain amino acids and L-carnitine was administered to tumor-bearing mice, investigating its effects on tumor and muscle tissues. Experiment (A): B16 melanoma cells were implanted subcutaneously into the right side of the abdomen of 8- to 9-week-old C57BL/6J mice. The mice were divided into two groups: a FDS group that received oral administration of FDS (n=10), and a control group that received oral administration of glucose (n=10). The moribund condition was used as the endpoint, and median survival time was determined. Experiment (B): On day 21 after tumor implantation, tumors, soleus muscle, gastrocnemius muscle, and suprahyoid muscles were collected. Tumor and muscle weight and other aspects were evaluated in each group: FDS group (n=15) and control group (n=15). The median survival time was comparable (21 d in the FDS group vs. 18 d in the control group, p=0.30). However, cumulative food intake was significantly higher in the FDS group than the control group (p=0.011). Metastasis of melanoma to the lung was observed in the control group but not in the FDS group (p=0.043). The weight of the suprahyoid muscles was significantly higher in the FDS group than in the control group (p=0.0045). The weight of the tumor was significantly lower in the FDS group than in the control group (p=0.013). The results possibly suggest oral administration of FDS in tumor-bearing mice enhances the maintenance of suprahyoid muscles, resulting in an extended feeding period and suppression of tumor growth and metastasis. |
| doi_str_mv | 10.1248/bpb.b16-00638 |
| format | Article |
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Experiment (A): B16 melanoma cells were implanted subcutaneously into the right side of the abdomen of 8- to 9-week-old C57BL/6J mice. The mice were divided into two groups: a FDS group that received oral administration of FDS (n=10), and a control group that received oral administration of glucose (n=10). The moribund condition was used as the endpoint, and median survival time was determined. Experiment (B): On day 21 after tumor implantation, tumors, soleus muscle, gastrocnemius muscle, and suprahyoid muscles were collected. Tumor and muscle weight and other aspects were evaluated in each group: FDS group (n=15) and control group (n=15). The median survival time was comparable (21 d in the FDS group vs. 18 d in the control group, p=0.30). However, cumulative food intake was significantly higher in the FDS group than the control group (p=0.011). Metastasis of melanoma to the lung was observed in the control group but not in the FDS group (p=0.043). The weight of the suprahyoid muscles was significantly higher in the FDS group than in the control group (p=0.0045). The weight of the tumor was significantly lower in the FDS group than in the control group (p=0.013). The results possibly suggest oral administration of FDS in tumor-bearing mice enhances the maintenance of suprahyoid muscles, resulting in an extended feeding period and suppression of tumor growth and metastasis.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.b16-00638</identifier><identifier>PMID: 28123134</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>Amino acids ; Amino Acids, Branched-Chain - pharmacology ; Amino Acids, Branched-Chain - therapeutic use ; Animals ; branched-chain amino acid ; cachexia ; Cachexia - prevention & control ; cancer therapy ; Carnitine ; Carnitine - pharmacology ; Carnitine - therapeutic use ; Citric acid ; Citric Acid - pharmacology ; Citric Acid - therapeutic use ; Coenzyme Q10 ; Combined treatment ; Dietary Supplements ; Eating - drug effects ; Food intake ; functional maintenance ; Gastrocnemius muscle ; Lungs ; Male ; Melanoma ; Melanoma, Experimental - complications ; Melanoma, Experimental - drug therapy ; metabolism ; Metastases ; Metastasis ; Mice ; Mice, Inbred C57BL ; Micronutrients - pharmacology ; Micronutrients - therapeutic use ; Muscle, Skeletal - drug effects ; Muscles ; Oral administration ; Rodents ; Soleus muscle ; Supermarkets ; Survival ; Tissues ; Tumors ; Ubiquinone - analogs & derivatives ; Ubiquinone - pharmacology ; Ubiquinone - therapeutic use ; Vitamins ; Vitamins - pharmacology ; Vitamins - therapeutic use ; Zinc ; Zinc - pharmacology ; Zinc - therapeutic use</subject><ispartof>Biological and Pharmaceutical Bulletin, 2017/03/01, Vol.40(3), pp.266-271</ispartof><rights>2017 The Pharmaceutical Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c510t-8bca69633a2d125551316e447973d983c4bb84ef29c3d3945f7de18933a951f83</citedby><cites>FETCH-LOGICAL-c510t-8bca69633a2d125551316e447973d983c4bb84ef29c3d3945f7de18933a951f83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28123134$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Awa, Hiroko</creatorcontrib><creatorcontrib>Futamura, Akihiko</creatorcontrib><creatorcontrib>Higashiguchi, Takashi</creatorcontrib><creatorcontrib>Ito, Akihiro</creatorcontrib><creatorcontrib>Mori, Naoharu</creatorcontrib><creatorcontrib>Murai, Miyo</creatorcontrib><creatorcontrib>Ohara, Hiroshi</creatorcontrib><creatorcontrib>Chihara, Takeshi</creatorcontrib><creatorcontrib>Kaneko, Takaaki</creatorcontrib><title>Effects of Combined Treatment with Branched-Chain Amino Acids, Citric Acid, L-Carnitine, Coenzyme Q10, Zinc, and Various Vitamins in Tumor-Bearing Mice</title><title>Biological & pharmaceutical bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>A functional dietary supplement (FDS) containing Coenzyme Q10, branched-chain amino acids and L-carnitine was administered to tumor-bearing mice, investigating its effects on tumor and muscle tissues. Experiment (A): B16 melanoma cells were implanted subcutaneously into the right side of the abdomen of 8- to 9-week-old C57BL/6J mice. The mice were divided into two groups: a FDS group that received oral administration of FDS (n=10), and a control group that received oral administration of glucose (n=10). The moribund condition was used as the endpoint, and median survival time was determined. Experiment (B): On day 21 after tumor implantation, tumors, soleus muscle, gastrocnemius muscle, and suprahyoid muscles were collected. Tumor and muscle weight and other aspects were evaluated in each group: FDS group (n=15) and control group (n=15). The median survival time was comparable (21 d in the FDS group vs. 18 d in the control group, p=0.30). However, cumulative food intake was significantly higher in the FDS group than the control group (p=0.011). Metastasis of melanoma to the lung was observed in the control group but not in the FDS group (p=0.043). The weight of the suprahyoid muscles was significantly higher in the FDS group than in the control group (p=0.0045). The weight of the tumor was significantly lower in the FDS group than in the control group (p=0.013). The results possibly suggest oral administration of FDS in tumor-bearing mice enhances the maintenance of suprahyoid muscles, resulting in an extended feeding period and suppression of tumor growth and metastasis.</description><subject>Amino acids</subject><subject>Amino Acids, Branched-Chain - pharmacology</subject><subject>Amino Acids, Branched-Chain - therapeutic use</subject><subject>Animals</subject><subject>branched-chain amino acid</subject><subject>cachexia</subject><subject>Cachexia - prevention & control</subject><subject>cancer therapy</subject><subject>Carnitine</subject><subject>Carnitine - pharmacology</subject><subject>Carnitine - therapeutic use</subject><subject>Citric acid</subject><subject>Citric Acid - pharmacology</subject><subject>Citric Acid - therapeutic use</subject><subject>Coenzyme Q10</subject><subject>Combined treatment</subject><subject>Dietary Supplements</subject><subject>Eating - drug effects</subject><subject>Food intake</subject><subject>functional maintenance</subject><subject>Gastrocnemius muscle</subject><subject>Lungs</subject><subject>Male</subject><subject>Melanoma</subject><subject>Melanoma, Experimental - complications</subject><subject>Melanoma, Experimental - drug therapy</subject><subject>metabolism</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Micronutrients - pharmacology</subject><subject>Micronutrients - therapeutic use</subject><subject>Muscle, Skeletal - drug effects</subject><subject>Muscles</subject><subject>Oral administration</subject><subject>Rodents</subject><subject>Soleus muscle</subject><subject>Supermarkets</subject><subject>Survival</subject><subject>Tissues</subject><subject>Tumors</subject><subject>Ubiquinone - analogs & derivatives</subject><subject>Ubiquinone - pharmacology</subject><subject>Ubiquinone - therapeutic use</subject><subject>Vitamins</subject><subject>Vitamins - pharmacology</subject><subject>Vitamins - therapeutic use</subject><subject>Zinc</subject><subject>Zinc - pharmacology</subject><subject>Zinc - therapeutic use</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc1uEzEURi1ERdPCki2yxIZFXPw3M55lOmoBKVWFFLpgY3k8dxpHGU-wPULlRXhdnKTNgo2vrO_coyt9CL1n9IpxqT63u_aqZSWhtBTqFZoxIStScFa8RjNaM0VKVqhzdBHjhlJaUS7eoHOuGBeZnKG_N30PNkU89rgZh9Z56PAqgEkD-IR_u7TG18F4u4aONGvjPF4Mzo94YV0X57hxKTh7-M3xkjQmeJeyJCcj-D9PA-DvjM7xT-ftHBvf4QcT3DhF_OCSyaaIs3I1DWMg15Aj_4jvnIW36Kw32wjvnucl-nF7s2q-kuX9l2_NYklswWgiqrWmrEshDO8YL4qCCVaClFVdia5Wwsq2VRJ6XlvRiVoWfdUBU3VeqAvWK3GJPh29uzD-miAmPbhoYbs1HvKVmqmSc8WFlBn9-B-6Gafg83WZqqRUtSz3FDlSNowxBuj1LrjBhCfNqN43pnNjOjemD41l_sOzdWoH6E70S0UZaI7AJibzCCfAhOTsFg46SbXYPyftKbVrEzR48Q-3GKcU</recordid><startdate>20170301</startdate><enddate>20170301</enddate><creator>Awa, Hiroko</creator><creator>Futamura, Akihiko</creator><creator>Higashiguchi, Takashi</creator><creator>Ito, Akihiro</creator><creator>Mori, Naoharu</creator><creator>Murai, Miyo</creator><creator>Ohara, Hiroshi</creator><creator>Chihara, Takeshi</creator><creator>Kaneko, Takaaki</creator><general>The Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20170301</creationdate><title>Effects of Combined Treatment with Branched-Chain Amino Acids, Citric Acid, L-Carnitine, Coenzyme Q10, Zinc, and Various Vitamins in Tumor-Bearing Mice</title><author>Awa, Hiroko ; Futamura, Akihiko ; Higashiguchi, Takashi ; Ito, Akihiro ; Mori, Naoharu ; Murai, Miyo ; Ohara, Hiroshi ; Chihara, Takeshi ; Kaneko, Takaaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c510t-8bca69633a2d125551316e447973d983c4bb84ef29c3d3945f7de18933a951f83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Amino acids</topic><topic>Amino Acids, Branched-Chain - pharmacology</topic><topic>Amino Acids, Branched-Chain - therapeutic use</topic><topic>Animals</topic><topic>branched-chain amino acid</topic><topic>cachexia</topic><topic>Cachexia - prevention & control</topic><topic>cancer therapy</topic><topic>Carnitine</topic><topic>Carnitine - pharmacology</topic><topic>Carnitine - therapeutic use</topic><topic>Citric acid</topic><topic>Citric Acid - pharmacology</topic><topic>Citric Acid - therapeutic use</topic><topic>Coenzyme Q10</topic><topic>Combined treatment</topic><topic>Dietary Supplements</topic><topic>Eating - drug effects</topic><topic>Food intake</topic><topic>functional maintenance</topic><topic>Gastrocnemius muscle</topic><topic>Lungs</topic><topic>Male</topic><topic>Melanoma</topic><topic>Melanoma, Experimental - complications</topic><topic>Melanoma, Experimental - drug therapy</topic><topic>metabolism</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Micronutrients - pharmacology</topic><topic>Micronutrients - therapeutic use</topic><topic>Muscle, Skeletal - drug effects</topic><topic>Muscles</topic><topic>Oral administration</topic><topic>Rodents</topic><topic>Soleus muscle</topic><topic>Supermarkets</topic><topic>Survival</topic><topic>Tissues</topic><topic>Tumors</topic><topic>Ubiquinone - analogs & derivatives</topic><topic>Ubiquinone - pharmacology</topic><topic>Ubiquinone - therapeutic use</topic><topic>Vitamins</topic><topic>Vitamins - pharmacology</topic><topic>Vitamins - therapeutic use</topic><topic>Zinc</topic><topic>Zinc - pharmacology</topic><topic>Zinc - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Awa, Hiroko</creatorcontrib><creatorcontrib>Futamura, Akihiko</creatorcontrib><creatorcontrib>Higashiguchi, Takashi</creatorcontrib><creatorcontrib>Ito, Akihiro</creatorcontrib><creatorcontrib>Mori, Naoharu</creatorcontrib><creatorcontrib>Murai, Miyo</creatorcontrib><creatorcontrib>Ohara, Hiroshi</creatorcontrib><creatorcontrib>Chihara, Takeshi</creatorcontrib><creatorcontrib>Kaneko, Takaaki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biological & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Awa, Hiroko</au><au>Futamura, Akihiko</au><au>Higashiguchi, Takashi</au><au>Ito, Akihiro</au><au>Mori, Naoharu</au><au>Murai, Miyo</au><au>Ohara, Hiroshi</au><au>Chihara, Takeshi</au><au>Kaneko, Takaaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Combined Treatment with Branched-Chain Amino Acids, Citric Acid, L-Carnitine, Coenzyme Q10, Zinc, and Various Vitamins in Tumor-Bearing Mice</atitle><jtitle>Biological & pharmaceutical bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>2017-03-01</date><risdate>2017</risdate><volume>40</volume><issue>3</issue><spage>266</spage><epage>271</epage><pages>266-271</pages><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>A functional dietary supplement (FDS) containing Coenzyme Q10, branched-chain amino acids and L-carnitine was administered to tumor-bearing mice, investigating its effects on tumor and muscle tissues. Experiment (A): B16 melanoma cells were implanted subcutaneously into the right side of the abdomen of 8- to 9-week-old C57BL/6J mice. The mice were divided into two groups: a FDS group that received oral administration of FDS (n=10), and a control group that received oral administration of glucose (n=10). The moribund condition was used as the endpoint, and median survival time was determined. Experiment (B): On day 21 after tumor implantation, tumors, soleus muscle, gastrocnemius muscle, and suprahyoid muscles were collected. Tumor and muscle weight and other aspects were evaluated in each group: FDS group (n=15) and control group (n=15). The median survival time was comparable (21 d in the FDS group vs. 18 d in the control group, p=0.30). However, cumulative food intake was significantly higher in the FDS group than the control group (p=0.011). Metastasis of melanoma to the lung was observed in the control group but not in the FDS group (p=0.043). The weight of the suprahyoid muscles was significantly higher in the FDS group than in the control group (p=0.0045). The weight of the tumor was significantly lower in the FDS group than in the control group (p=0.013). The results possibly suggest oral administration of FDS in tumor-bearing mice enhances the maintenance of suprahyoid muscles, resulting in an extended feeding period and suppression of tumor growth and metastasis.</abstract><cop>Japan</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>28123134</pmid><doi>10.1248/bpb.b16-00638</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Amino acids Amino Acids, Branched-Chain - pharmacology Amino Acids, Branched-Chain - therapeutic use Animals branched-chain amino acid cachexia Cachexia - prevention & control cancer therapy Carnitine Carnitine - pharmacology Carnitine - therapeutic use Citric acid Citric Acid - pharmacology Citric Acid - therapeutic use Coenzyme Q10 Combined treatment Dietary Supplements Eating - drug effects Food intake functional maintenance Gastrocnemius muscle Lungs Male Melanoma Melanoma, Experimental - complications Melanoma, Experimental - drug therapy metabolism Metastases Metastasis Mice Mice, Inbred C57BL Micronutrients - pharmacology Micronutrients - therapeutic use Muscle, Skeletal - drug effects Muscles Oral administration Rodents Soleus muscle Supermarkets Survival Tissues Tumors Ubiquinone - analogs & derivatives Ubiquinone - pharmacology Ubiquinone - therapeutic use Vitamins Vitamins - pharmacology Vitamins - therapeutic use Zinc Zinc - pharmacology Zinc - therapeutic use |
| title | Effects of Combined Treatment with Branched-Chain Amino Acids, Citric Acid, L-Carnitine, Coenzyme Q10, Zinc, and Various Vitamins in Tumor-Bearing Mice |
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