Is there room for behavioral and modifiable health-related targets in the lower urinary tract symptoms’ scenario

Purpose To better understand potential modifiable risk factors guiding preventive interventions against lower urinary tract symptoms (LUTS). Methods A prospective cross-sectional study, including healthy men aged 40–70 years under routine urological evaluation, measured the strength of association b...

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Veröffentlicht in:World journal of urology 2017-09, Vol.35 (9), p.1451-1454
Hauptverfasser: Ikari, Osamu, Sanches, Brunno C. F., Alonso, João Carlos Cardoso, Simões, Fabiano A., Rejowski, Ronald F., Laranja, Walker Wendel, Reis, Leonardo O.
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container_end_page 1454
container_issue 9
container_start_page 1451
container_title World journal of urology
container_volume 35
creator Ikari, Osamu
Sanches, Brunno C. F.
Alonso, João Carlos Cardoso
Simões, Fabiano A.
Rejowski, Ronald F.
Laranja, Walker Wendel
Reis, Leonardo O.
description Purpose To better understand potential modifiable risk factors guiding preventive interventions against lower urinary tract symptoms (LUTS). Methods A prospective cross-sectional study, including healthy men aged 40–70 years under routine urological evaluation, measured the strength of association between the International Prostate Symptom Score (IPSS) and socio-demographic, lifestyle, and health-related factors using logistic and linear regression adjusted for confounding factors. Men with urethral or prostate surgery were excluded. Results Among 743 men, mean age 59.64 ± 9.66, 22.6% reported moderate, and 5.0% severe LUTS. The adjusted odds of severe LUTS increased with: increasing age (OR = 1.07, 95% CI = 1.05–1.09, p  
doi_str_mv 10.1007/s00345-016-1999-8
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F. ; Alonso, João Carlos Cardoso ; Simões, Fabiano A. ; Rejowski, Ronald F. ; Laranja, Walker Wendel ; Reis, Leonardo O.</creator><creatorcontrib>Ikari, Osamu ; Sanches, Brunno C. F. ; Alonso, João Carlos Cardoso ; Simões, Fabiano A. ; Rejowski, Ronald F. ; Laranja, Walker Wendel ; Reis, Leonardo O.</creatorcontrib><description>Purpose To better understand potential modifiable risk factors guiding preventive interventions against lower urinary tract symptoms (LUTS). Methods A prospective cross-sectional study, including healthy men aged 40–70 years under routine urological evaluation, measured the strength of association between the International Prostate Symptom Score (IPSS) and socio-demographic, lifestyle, and health-related factors using logistic and linear regression adjusted for confounding factors. Men with urethral or prostate surgery were excluded. Results Among 743 men, mean age 59.64 ± 9.66, 22.6% reported moderate, and 5.0% severe LUTS. The adjusted odds of severe LUTS increased with: increasing age (OR = 1.07, 95% CI = 1.05–1.09, p  &lt; .0001), increasing prostate volume (OR = 1.02, 95% CI = 1.01–1.04, p  = .004), decreasing education (tertiary qualification, no versus yes, OR = 2.34; 95% CI = 1.16–4.70; p  = .0133), delayed ejaculation (yes versus no, OR = 2.63, 95% CI = 1.43–4.83, p  &lt; .0001), and increasing blood pressure (systolic ≥130 mmHg, OR = 2.03, 95% CI = 1.44–2.86, p  &lt; .0001 or diastolic ≥85 mmHg, OR = 1.47, 95% CI = 1.03–2.10, p  = .0345); severe LUTS decreased with: increasing the weekly sexual frequency (OR = 0.80, 95% CI = 0.69–0.91, p  = .0012) and increasing HDL cholesterol (OR = 0.98, 95% CI = 0.97–0.99, p  = .037). Odds were not significant for age of sexual initiation, precocious ejaculation, masturbatory pattern, physical activity, smoking, alcohol consumption, penile length (objective and subjective), abdominal circumference, obesity, comorbid conditions, metabolic syndrome, serum glycaemia, testosterone, SHBG, PSA, and estradiol. Conclusions One in every four men under routine urological evaluation who considered themselves healthy present moderate and severe LUTS. Modifiable behavioral (education, sexual frequency, and ejaculation) and health-related (blood pressure and HDL cholesterol) targets were identified for future interventional studies and potential preventive actions and patient counseling.</description><identifier>ISSN: 0724-4983</identifier><identifier>EISSN: 1433-8726</identifier><identifier>DOI: 10.1007/s00345-016-1999-8</identifier><identifier>PMID: 28124112</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>17β-Estradiol ; Adult ; Aged ; Alcohol Drinking - epidemiology ; Blood glucose ; Blood Glucose - metabolism ; Blood Pressure ; Cholesterol ; Cholesterol, HDL - metabolism ; Cross-Sectional Studies ; Educational Status ; Ejaculation ; Estradiol - metabolism ; Exercise ; Health risk assessment ; High density lipoprotein ; Humans ; Kallikreins - metabolism ; Linear Models ; Logistic Models ; Lower Urinary Tract Symptoms - epidemiology ; Lower Urinary Tract Symptoms - metabolism ; Male ; Medicine ; Medicine &amp; Public Health ; Mens health ; Metabolic syndrome ; Metabolic Syndrome - epidemiology ; Middle Aged ; Nephrology ; Obesity - epidemiology ; Odds Ratio ; Oncology ; Organ Size ; Original Article ; Penis ; Penis - anatomy &amp; histology ; Physical activity ; Prospective Studies ; Prostate ; Prostate - pathology ; Prostate-Specific Antigen - metabolism ; Risk Factors ; Severity of Illness Index ; Sex Hormone-Binding Globulin - metabolism ; Sexual Behavior - statistics &amp; numerical data ; Smoking ; Smoking - epidemiology ; Surgery ; Testosterone ; Testosterone - metabolism ; Urinary tract ; Urogenital system ; Urology</subject><ispartof>World journal of urology, 2017-09, Vol.35 (9), p.1451-1454</ispartof><rights>Springer-Verlag Berlin Heidelberg 2017</rights><rights>World Journal of Urology is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-79bbbd9fd4a8fc3f93ae388ffa69ca6bb975968c592a09e2889132b9b2b6ac5b3</citedby><cites>FETCH-LOGICAL-c372t-79bbbd9fd4a8fc3f93ae388ffa69ca6bb975968c592a09e2889132b9b2b6ac5b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00345-016-1999-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00345-016-1999-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28124112$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ikari, Osamu</creatorcontrib><creatorcontrib>Sanches, Brunno C. F.</creatorcontrib><creatorcontrib>Alonso, João Carlos Cardoso</creatorcontrib><creatorcontrib>Simões, Fabiano A.</creatorcontrib><creatorcontrib>Rejowski, Ronald F.</creatorcontrib><creatorcontrib>Laranja, Walker Wendel</creatorcontrib><creatorcontrib>Reis, Leonardo O.</creatorcontrib><title>Is there room for behavioral and modifiable health-related targets in the lower urinary tract symptoms’ scenario</title><title>World journal of urology</title><addtitle>World J Urol</addtitle><addtitle>World J Urol</addtitle><description>Purpose To better understand potential modifiable risk factors guiding preventive interventions against lower urinary tract symptoms (LUTS). Methods A prospective cross-sectional study, including healthy men aged 40–70 years under routine urological evaluation, measured the strength of association between the International Prostate Symptom Score (IPSS) and socio-demographic, lifestyle, and health-related factors using logistic and linear regression adjusted for confounding factors. Men with urethral or prostate surgery were excluded. Results Among 743 men, mean age 59.64 ± 9.66, 22.6% reported moderate, and 5.0% severe LUTS. The adjusted odds of severe LUTS increased with: increasing age (OR = 1.07, 95% CI = 1.05–1.09, p  &lt; .0001), increasing prostate volume (OR = 1.02, 95% CI = 1.01–1.04, p  = .004), decreasing education (tertiary qualification, no versus yes, OR = 2.34; 95% CI = 1.16–4.70; p  = .0133), delayed ejaculation (yes versus no, OR = 2.63, 95% CI = 1.43–4.83, p  &lt; .0001), and increasing blood pressure (systolic ≥130 mmHg, OR = 2.03, 95% CI = 1.44–2.86, p  &lt; .0001 or diastolic ≥85 mmHg, OR = 1.47, 95% CI = 1.03–2.10, p  = .0345); severe LUTS decreased with: increasing the weekly sexual frequency (OR = 0.80, 95% CI = 0.69–0.91, p  = .0012) and increasing HDL cholesterol (OR = 0.98, 95% CI = 0.97–0.99, p  = .037). Odds were not significant for age of sexual initiation, precocious ejaculation, masturbatory pattern, physical activity, smoking, alcohol consumption, penile length (objective and subjective), abdominal circumference, obesity, comorbid conditions, metabolic syndrome, serum glycaemia, testosterone, SHBG, PSA, and estradiol. Conclusions One in every four men under routine urological evaluation who considered themselves healthy present moderate and severe LUTS. Modifiable behavioral (education, sexual frequency, and ejaculation) and health-related (blood pressure and HDL cholesterol) targets were identified for future interventional studies and potential preventive actions and patient counseling.</description><subject>17β-Estradiol</subject><subject>Adult</subject><subject>Aged</subject><subject>Alcohol Drinking - epidemiology</subject><subject>Blood glucose</subject><subject>Blood Glucose - metabolism</subject><subject>Blood Pressure</subject><subject>Cholesterol</subject><subject>Cholesterol, HDL - metabolism</subject><subject>Cross-Sectional Studies</subject><subject>Educational Status</subject><subject>Ejaculation</subject><subject>Estradiol - metabolism</subject><subject>Exercise</subject><subject>Health risk assessment</subject><subject>High density lipoprotein</subject><subject>Humans</subject><subject>Kallikreins - metabolism</subject><subject>Linear Models</subject><subject>Logistic Models</subject><subject>Lower Urinary Tract Symptoms - epidemiology</subject><subject>Lower Urinary Tract Symptoms - metabolism</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Mens health</subject><subject>Metabolic syndrome</subject><subject>Metabolic Syndrome - epidemiology</subject><subject>Middle Aged</subject><subject>Nephrology</subject><subject>Obesity - epidemiology</subject><subject>Odds Ratio</subject><subject>Oncology</subject><subject>Organ Size</subject><subject>Original Article</subject><subject>Penis</subject><subject>Penis - anatomy &amp; histology</subject><subject>Physical activity</subject><subject>Prospective Studies</subject><subject>Prostate</subject><subject>Prostate - pathology</subject><subject>Prostate-Specific Antigen - metabolism</subject><subject>Risk Factors</subject><subject>Severity of Illness Index</subject><subject>Sex Hormone-Binding Globulin - metabolism</subject><subject>Sexual Behavior - statistics &amp; numerical data</subject><subject>Smoking</subject><subject>Smoking - epidemiology</subject><subject>Surgery</subject><subject>Testosterone</subject><subject>Testosterone - metabolism</subject><subject>Urinary tract</subject><subject>Urogenital system</subject><subject>Urology</subject><issn>0724-4983</issn><issn>1433-8726</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kc-KFDEQh4Mo7rj6AF4k4MVLNJX0n-Qoy6oLC170HCrdlZ1eujtjklb25mv4ej6JGWYVETzVob76VRUfY89BvgYp-zdZSt20QkInwForzAO2g0ZrYXrVPWQ72atGNNboM_Yk51spoe9k-5idKQOqAVA7lq4yL3tKxFOMCw8xcU97_DrFhDPHdeRLHKcwoZ-J7wnnsheJZiw08oLphkrm03qM4HP8RolvaVox3fGScCg83y2HEpf88_sPngeqnSk-ZY8Czpme3ddz9vnd5aeLD-L64_uri7fXYtC9KqK33vvRhrFBEwYdrEbSxoSAnR2w8972re3M0FqF0pIyxoJW3nrlOxxar8_Zq1PuIcUvG-XilqneMM-4UtyyA9MpZZQ0bUVf_oPexi2t9ToHVrdgJYCsFJyoIcWcEwV3SNNSn3Ug3VGIOwlxVYg7CnGmzry4T978QuOfid8GKqBOQK6t9YbSX6v_m_oL7I6Yew</recordid><startdate>20170901</startdate><enddate>20170901</enddate><creator>Ikari, Osamu</creator><creator>Sanches, Brunno C. 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F. ; Alonso, João Carlos Cardoso ; Simões, Fabiano A. ; Rejowski, Ronald F. ; Laranja, Walker Wendel ; Reis, Leonardo O.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-79bbbd9fd4a8fc3f93ae388ffa69ca6bb975968c592a09e2889132b9b2b6ac5b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>17β-Estradiol</topic><topic>Adult</topic><topic>Aged</topic><topic>Alcohol Drinking - epidemiology</topic><topic>Blood glucose</topic><topic>Blood Glucose - metabolism</topic><topic>Blood Pressure</topic><topic>Cholesterol</topic><topic>Cholesterol, HDL - metabolism</topic><topic>Cross-Sectional Studies</topic><topic>Educational Status</topic><topic>Ejaculation</topic><topic>Estradiol - metabolism</topic><topic>Exercise</topic><topic>Health risk assessment</topic><topic>High density lipoprotein</topic><topic>Humans</topic><topic>Kallikreins - metabolism</topic><topic>Linear Models</topic><topic>Logistic Models</topic><topic>Lower Urinary Tract Symptoms - epidemiology</topic><topic>Lower Urinary Tract Symptoms - metabolism</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine &amp; Public Health</topic><topic>Mens health</topic><topic>Metabolic syndrome</topic><topic>Metabolic Syndrome - epidemiology</topic><topic>Middle Aged</topic><topic>Nephrology</topic><topic>Obesity - epidemiology</topic><topic>Odds Ratio</topic><topic>Oncology</topic><topic>Organ Size</topic><topic>Original Article</topic><topic>Penis</topic><topic>Penis - anatomy &amp; histology</topic><topic>Physical activity</topic><topic>Prospective Studies</topic><topic>Prostate</topic><topic>Prostate - pathology</topic><topic>Prostate-Specific Antigen - metabolism</topic><topic>Risk Factors</topic><topic>Severity of Illness Index</topic><topic>Sex Hormone-Binding Globulin - metabolism</topic><topic>Sexual Behavior - statistics &amp; numerical data</topic><topic>Smoking</topic><topic>Smoking - epidemiology</topic><topic>Surgery</topic><topic>Testosterone</topic><topic>Testosterone - metabolism</topic><topic>Urinary tract</topic><topic>Urogenital system</topic><topic>Urology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ikari, Osamu</creatorcontrib><creatorcontrib>Sanches, Brunno C. F.</creatorcontrib><creatorcontrib>Alonso, João Carlos Cardoso</creatorcontrib><creatorcontrib>Simões, Fabiano A.</creatorcontrib><creatorcontrib>Rejowski, Ronald F.</creatorcontrib><creatorcontrib>Laranja, Walker Wendel</creatorcontrib><creatorcontrib>Reis, Leonardo O.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>World journal of urology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ikari, Osamu</au><au>Sanches, Brunno C. F.</au><au>Alonso, João Carlos Cardoso</au><au>Simões, Fabiano A.</au><au>Rejowski, Ronald F.</au><au>Laranja, Walker Wendel</au><au>Reis, Leonardo O.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Is there room for behavioral and modifiable health-related targets in the lower urinary tract symptoms’ scenario</atitle><jtitle>World journal of urology</jtitle><stitle>World J Urol</stitle><addtitle>World J Urol</addtitle><date>2017-09-01</date><risdate>2017</risdate><volume>35</volume><issue>9</issue><spage>1451</spage><epage>1454</epage><pages>1451-1454</pages><issn>0724-4983</issn><eissn>1433-8726</eissn><abstract>Purpose To better understand potential modifiable risk factors guiding preventive interventions against lower urinary tract symptoms (LUTS). Methods A prospective cross-sectional study, including healthy men aged 40–70 years under routine urological evaluation, measured the strength of association between the International Prostate Symptom Score (IPSS) and socio-demographic, lifestyle, and health-related factors using logistic and linear regression adjusted for confounding factors. Men with urethral or prostate surgery were excluded. Results Among 743 men, mean age 59.64 ± 9.66, 22.6% reported moderate, and 5.0% severe LUTS. The adjusted odds of severe LUTS increased with: increasing age (OR = 1.07, 95% CI = 1.05–1.09, p  &lt; .0001), increasing prostate volume (OR = 1.02, 95% CI = 1.01–1.04, p  = .004), decreasing education (tertiary qualification, no versus yes, OR = 2.34; 95% CI = 1.16–4.70; p  = .0133), delayed ejaculation (yes versus no, OR = 2.63, 95% CI = 1.43–4.83, p  &lt; .0001), and increasing blood pressure (systolic ≥130 mmHg, OR = 2.03, 95% CI = 1.44–2.86, p  &lt; .0001 or diastolic ≥85 mmHg, OR = 1.47, 95% CI = 1.03–2.10, p  = .0345); severe LUTS decreased with: increasing the weekly sexual frequency (OR = 0.80, 95% CI = 0.69–0.91, p  = .0012) and increasing HDL cholesterol (OR = 0.98, 95% CI = 0.97–0.99, p  = .037). Odds were not significant for age of sexual initiation, precocious ejaculation, masturbatory pattern, physical activity, smoking, alcohol consumption, penile length (objective and subjective), abdominal circumference, obesity, comorbid conditions, metabolic syndrome, serum glycaemia, testosterone, SHBG, PSA, and estradiol. Conclusions One in every four men under routine urological evaluation who considered themselves healthy present moderate and severe LUTS. Modifiable behavioral (education, sexual frequency, and ejaculation) and health-related (blood pressure and HDL cholesterol) targets were identified for future interventional studies and potential preventive actions and patient counseling.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>28124112</pmid><doi>10.1007/s00345-016-1999-8</doi><tpages>4</tpages></addata></record>
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subjects 17β-Estradiol
Adult
Aged
Alcohol Drinking - epidemiology
Blood glucose
Blood Glucose - metabolism
Blood Pressure
Cholesterol
Cholesterol, HDL - metabolism
Cross-Sectional Studies
Educational Status
Ejaculation
Estradiol - metabolism
Exercise
Health risk assessment
High density lipoprotein
Humans
Kallikreins - metabolism
Linear Models
Logistic Models
Lower Urinary Tract Symptoms - epidemiology
Lower Urinary Tract Symptoms - metabolism
Male
Medicine
Medicine & Public Health
Mens health
Metabolic syndrome
Metabolic Syndrome - epidemiology
Middle Aged
Nephrology
Obesity - epidemiology
Odds Ratio
Oncology
Organ Size
Original Article
Penis
Penis - anatomy & histology
Physical activity
Prospective Studies
Prostate
Prostate - pathology
Prostate-Specific Antigen - metabolism
Risk Factors
Severity of Illness Index
Sex Hormone-Binding Globulin - metabolism
Sexual Behavior - statistics & numerical data
Smoking
Smoking - epidemiology
Surgery
Testosterone
Testosterone - metabolism
Urinary tract
Urogenital system
Urology
title Is there room for behavioral and modifiable health-related targets in the lower urinary tract symptoms’ scenario
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