The Nucleotide-binding Site of Human Sphingosine Kinase 1

Sphingosine kinase catalyzes the formation of sphingosine 1-phosphate, a lipid second messenger that has been implicated in a number of agonist-driven cellular responses including mitogenesis, anti-apoptosis, and expression of inflammatory molecules. Despite the importance of sphingosine kinase, ver...

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Veröffentlicht in:	The Journal of biological chemistry 2002-12, Vol.277 (51), p.49545-49553
Hauptverfasser:	Pitson, Stuart M., Moretti, Paul A.B., Zebol, Julia R., Zareie, Reza, Derian, Claudia K., Darrow, Andrew L., Qi, Jenson, D'Andrea, Richard J., Bagley, Christopher J., Vadas, Mathew A., Wattenberg, Binks W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - analogs & derivatives Adenosine - pharmacology Adenosine Triphosphate - analogs & derivatives Adenosine Triphosphate - pharmacology Affinity Labels - pharmacology Alanine - chemistry Amino Acid Motifs Amino Acid Sequence Animals Azides - pharmacology Baculoviridae - metabolism Binding Sites Blotting, Western Calmodulin - metabolism Catalysis Catalytic Domain Cell Line DNA, Complementary - metabolism Gene Deletion Humans Insecta Kinetics Lysine - chemistry Mass Spectrometry Molecular Sequence Data Mutagenesis, Site-Directed Mutation Nucleotides - chemistry Phosphotransferases (Alcohol Group Acceptor) - chemistry Phosphotransferases (Alcohol Group Acceptor) - genetics Phosphotransferases (Alcohol Group Acceptor) - metabolism Photoaffinity Labels - pharmacology Protein Binding Protein Folding Protein Structure, Tertiary Recombinant Proteins - metabolism Sequence Homology, Amino Acid Substrate Specificity Transfection
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