Sedentary Behavior and Cardiovascular Disease Risk: Mediating Mechanisms

Sedentary Behavior and Cardiovascular Disease Risk: Mediating Mechanisms

Sedentary behavior has a strong association with cardiovascular disease (CVD) risk, which may be independent of physical activity. To date, the mechanism(s) that mediate this relationship are poorly understood. We hypothesize that sedentary behavior modifies key hemodynamic, inflammatory, and metabo...

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Veröffentlicht in:Exercise and sport sciences reviews 2017-04, Vol.45 (2), p.80-86
Hauptverfasser: Carter, Sophie, Hartman, Yvonne, Holder, Sophie, Thijssen, Dick H, Hopkins, Nicola D
Format: Artikel
Sprache:eng
Schlagworte:
Blood Glucose - metabolism
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - mortality
Cardiovascular Diseases - physiopathology
Exercise - physiology
Hemodynamics - physiology
Humans
Inflammation - physiopathology
Oxidative Stress - physiology
Risk Factors
Sedentary Lifestyle
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Zusammenfassung:Sedentary behavior has a strong association with cardiovascular disease (CVD) risk, which may be independent of physical activity. To date, the mechanism(s) that mediate this relationship are poorly understood. We hypothesize that sedentary behavior modifies key hemodynamic, inflammatory, and metabolic processes resulting in impaired arterial health. Subsequently, these vascular impairments directly and indirectly contribute to the development of CVD.
ISSN:0091-6331
1538-3008
DOI:10.1249/jes.0000000000000106