Effect of 6-gingerol on AMPK- NF-κB axis in high fat diet fed rats

Abstract Objectives Adenosine monophosphate (AMP)-activated protein kinase (AMPK) plays a central role in metabolic homeostasis and regulation of inflammatory responses through attenuation of nuclear factor kappa-B (NF-κB), Thus AMPK may be a promising pharmacologic target for the treatment of vario...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2017-04, Vol.88, p.293-301
Hauptverfasser:	Hashem, Reem M, Rashed, Laila A, Hassanin, Kamel M.A, Hetta, Mona H, Ahmed, Asmaa O
Format:	Artikel
Sprache:	eng
Schlagworte:	6-Gingerol Adipose Tissue - pathology AMP-Activated Protein Kinases - drug effects AMP-Activated Protein Kinases - metabolism AMPK Animals Body Weight - drug effects Catechols - pharmacology Diet, High-Fat - adverse effects Fatty Alcohols - pharmacology Fish Oils High fat diet Internal Medicine Male Medical Education NF-kappa B - drug effects NF-kappa B - metabolism p65 Phosphorylation Rats Rats, Wistar Resistin Signal Transduction - drug effects Sirtuin 6 Sirtuins - drug effects Sirtuins - metabolism Transcription Factor RelA - drug effects Transcription Factor RelA - metabolism Tumor Necrosis Factor-alpha - metabolism Zingiber officinale - chemistry
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