Post-mortem whole-body magnetic resonance imaging of human fetuses: a comparison of 3-T vs. 1.5-T MR imaging with classical autopsy

Objective To prospectively compare diagnostic accuracy of fetal post-mortem whole-body MRI at 3-T vs. 1.5-T. Methods Between 2012 and 2015, post-mortem MRI at 1.5-T and 3-T was performed in fetuses after miscarriage/stillbirth or termination. Clinical MRI diagnoses were assessed using a confidence d...

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Veröffentlicht in:European radiology 2017-08, Vol.27 (8), p.3542-3553
Hauptverfasser: Kang, Xin, Cannie, Mieke M., Arthurs, Owen J., Segers, Valerie, Fourneau, Catherine, Bevilacqua, Elisa, Cos Sanchez, Teresa, Sebire, Neil J., Jani, Jacques C.
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container_end_page 3553
container_issue 8
container_start_page 3542
container_title European radiology
container_volume 27
creator Kang, Xin
Cannie, Mieke M.
Arthurs, Owen J.
Segers, Valerie
Fourneau, Catherine
Bevilacqua, Elisa
Cos Sanchez, Teresa
Sebire, Neil J.
Jani, Jacques C.
description Objective To prospectively compare diagnostic accuracy of fetal post-mortem whole-body MRI at 3-T vs. 1.5-T. Methods Between 2012 and 2015, post-mortem MRI at 1.5-T and 3-T was performed in fetuses after miscarriage/stillbirth or termination. Clinical MRI diagnoses were assessed using a confidence diagnostic score and compared with classical autopsy to derive a diagnostic error score. The relation of diagnostic error for each organ group with gestational age was calculated and 1.5-T with 3-T was compared with accuracy analysis. Results 135 fetuses at 12–41 weeks underwent post-mortem MRI (followed by conventional autopsy in 92 fetuses). For all organ groups except the brain, and for both modalities, the diagnostic error decreased with gestation ( P  
doi_str_mv 10.1007/s00330-016-4725-4
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Methods Between 2012 and 2015, post-mortem MRI at 1.5-T and 3-T was performed in fetuses after miscarriage/stillbirth or termination. Clinical MRI diagnoses were assessed using a confidence diagnostic score and compared with classical autopsy to derive a diagnostic error score. The relation of diagnostic error for each organ group with gestational age was calculated and 1.5-T with 3-T was compared with accuracy analysis. Results 135 fetuses at 12–41 weeks underwent post-mortem MRI (followed by conventional autopsy in 92 fetuses). For all organ groups except the brain, and for both modalities, the diagnostic error decreased with gestation ( P  &lt; 0.0001). 3-T MRI diagnostic error was significantly lower than that of 1.5-T for all anatomic structures and organ groups, except the orbits and brain. This difference was maintained for fetuses &lt;20 weeks gestation. Moreover, 3-T was associated with fewer non-diagnostic scans and greater concordance with classical autopsy than 1.5-T MRI, especially for the thorax, heart and abdomen in fetuses &lt;20 weeks. Conclusion Post-mortem fetal 3-T MRI improves confidence scores and overall accuracy compared with 1.5-T, mainly for the thorax, heart and abdomen of fetuses &lt;20 weeks of gestation. Key Points • In PM-MRI, diagnostic error using 3-T is lower than that with 1.5-T. • In PM-MRI, diagnostic scan rate is higher using 3-T than 1.5-T. • In PM-MRI, concordance with classical autopsy increases with 3-T. • PM-MRI using 3-T is particularly interesting for thoracic and abdominal organs. • PM-MRI using 3-T is particularly interesting for fetuses &lt; 20 weeks’ gestation.</description><identifier>ISSN: 0938-7994</identifier><identifier>EISSN: 1432-1084</identifier><identifier>DOI: 10.1007/s00330-016-4725-4</identifier><identifier>PMID: 28116518</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Abdomen ; Abortion, Induced ; Abortion, Spontaneous - diagnostic imaging ; Abortion, Spontaneous - pathology ; Accuracy ; Autopsies ; Autopsy ; Autopsy - methods ; Brain ; Brain - diagnostic imaging ; Brain - pathology ; Condoms ; Diagnostic Errors ; Diagnostic Radiology ; Diagnostic systems ; Errors ; Female ; Fetal Diseases - diagnostic imaging ; Fetal Diseases - pathology ; Fetus - diagnostic imaging ; Fetus - pathology ; Fetuses ; Gestation ; Gestational Age ; Heart - diagnostic imaging ; Humans ; Imaging ; Internal Medicine ; Interventional Radiology ; Magnetic Resonance ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Medicine ; Medicine &amp; Public Health ; Miscarriage ; Myocardium - pathology ; Neuroimaging ; Neuroradiology ; NMR ; Nuclear magnetic resonance ; Organs ; Pregnancy ; Prospective Studies ; Radiology ; Stillbirth ; Thorax ; Thorax - diagnostic imaging ; Thorax - pathology ; Ultrasound ; Whole Body Imaging - methods</subject><ispartof>European radiology, 2017-08, Vol.27 (8), p.3542-3553</ispartof><rights>European Society of Radiology 2017</rights><rights>European Radiology is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-b5106d025455002862808dfd6855c6be0aec650ef7356b20bad8c160c06b2ccb3</citedby><cites>FETCH-LOGICAL-c415t-b5106d025455002862808dfd6855c6be0aec650ef7356b20bad8c160c06b2ccb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00330-016-4725-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00330-016-4725-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28116518$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kang, Xin</creatorcontrib><creatorcontrib>Cannie, Mieke M.</creatorcontrib><creatorcontrib>Arthurs, Owen J.</creatorcontrib><creatorcontrib>Segers, Valerie</creatorcontrib><creatorcontrib>Fourneau, Catherine</creatorcontrib><creatorcontrib>Bevilacqua, Elisa</creatorcontrib><creatorcontrib>Cos Sanchez, Teresa</creatorcontrib><creatorcontrib>Sebire, Neil J.</creatorcontrib><creatorcontrib>Jani, Jacques C.</creatorcontrib><title>Post-mortem whole-body magnetic resonance imaging of human fetuses: a comparison of 3-T vs. 1.5-T MR imaging with classical autopsy</title><title>European radiology</title><addtitle>Eur Radiol</addtitle><addtitle>Eur Radiol</addtitle><description>Objective To prospectively compare diagnostic accuracy of fetal post-mortem whole-body MRI at 3-T vs. 1.5-T. Methods Between 2012 and 2015, post-mortem MRI at 1.5-T and 3-T was performed in fetuses after miscarriage/stillbirth or termination. Clinical MRI diagnoses were assessed using a confidence diagnostic score and compared with classical autopsy to derive a diagnostic error score. The relation of diagnostic error for each organ group with gestational age was calculated and 1.5-T with 3-T was compared with accuracy analysis. Results 135 fetuses at 12–41 weeks underwent post-mortem MRI (followed by conventional autopsy in 92 fetuses). For all organ groups except the brain, and for both modalities, the diagnostic error decreased with gestation ( P  &lt; 0.0001). 3-T MRI diagnostic error was significantly lower than that of 1.5-T for all anatomic structures and organ groups, except the orbits and brain. This difference was maintained for fetuses &lt;20 weeks gestation. Moreover, 3-T was associated with fewer non-diagnostic scans and greater concordance with classical autopsy than 1.5-T MRI, especially for the thorax, heart and abdomen in fetuses &lt;20 weeks. Conclusion Post-mortem fetal 3-T MRI improves confidence scores and overall accuracy compared with 1.5-T, mainly for the thorax, heart and abdomen of fetuses &lt;20 weeks of gestation. Key Points • In PM-MRI, diagnostic error using 3-T is lower than that with 1.5-T. • In PM-MRI, diagnostic scan rate is higher using 3-T than 1.5-T. • In PM-MRI, concordance with classical autopsy increases with 3-T. • PM-MRI using 3-T is particularly interesting for thoracic and abdominal organs. • PM-MRI using 3-T is particularly interesting for fetuses &lt; 20 weeks’ gestation.</description><subject>Abdomen</subject><subject>Abortion, Induced</subject><subject>Abortion, Spontaneous - diagnostic imaging</subject><subject>Abortion, Spontaneous - pathology</subject><subject>Accuracy</subject><subject>Autopsies</subject><subject>Autopsy</subject><subject>Autopsy - methods</subject><subject>Brain</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - pathology</subject><subject>Condoms</subject><subject>Diagnostic Errors</subject><subject>Diagnostic Radiology</subject><subject>Diagnostic systems</subject><subject>Errors</subject><subject>Female</subject><subject>Fetal Diseases - diagnostic imaging</subject><subject>Fetal Diseases - pathology</subject><subject>Fetus - diagnostic imaging</subject><subject>Fetus - pathology</subject><subject>Fetuses</subject><subject>Gestation</subject><subject>Gestational Age</subject><subject>Heart - diagnostic imaging</subject><subject>Humans</subject><subject>Imaging</subject><subject>Internal Medicine</subject><subject>Interventional Radiology</subject><subject>Magnetic Resonance</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Medicine</subject><subject>Medicine &amp; 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Cannie, Mieke M. ; Arthurs, Owen J. ; Segers, Valerie ; Fourneau, Catherine ; Bevilacqua, Elisa ; Cos Sanchez, Teresa ; Sebire, Neil J. ; Jani, Jacques C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-b5106d025455002862808dfd6855c6be0aec650ef7356b20bad8c160c06b2ccb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Abdomen</topic><topic>Abortion, Induced</topic><topic>Abortion, Spontaneous - diagnostic imaging</topic><topic>Abortion, Spontaneous - pathology</topic><topic>Accuracy</topic><topic>Autopsies</topic><topic>Autopsy</topic><topic>Autopsy - methods</topic><topic>Brain</topic><topic>Brain - diagnostic imaging</topic><topic>Brain - pathology</topic><topic>Condoms</topic><topic>Diagnostic Errors</topic><topic>Diagnostic Radiology</topic><topic>Diagnostic systems</topic><topic>Errors</topic><topic>Female</topic><topic>Fetal Diseases - diagnostic imaging</topic><topic>Fetal Diseases - pathology</topic><topic>Fetus - diagnostic imaging</topic><topic>Fetus - pathology</topic><topic>Fetuses</topic><topic>Gestation</topic><topic>Gestational Age</topic><topic>Heart - diagnostic imaging</topic><topic>Humans</topic><topic>Imaging</topic><topic>Internal Medicine</topic><topic>Interventional Radiology</topic><topic>Magnetic Resonance</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Medicine</topic><topic>Medicine &amp; 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Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Advanced Technologies &amp; Aerospace Database</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>European radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kang, Xin</au><au>Cannie, Mieke M.</au><au>Arthurs, Owen J.</au><au>Segers, Valerie</au><au>Fourneau, Catherine</au><au>Bevilacqua, Elisa</au><au>Cos Sanchez, Teresa</au><au>Sebire, Neil J.</au><au>Jani, Jacques C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Post-mortem whole-body magnetic resonance imaging of human fetuses: a comparison of 3-T vs. 1.5-T MR imaging with classical autopsy</atitle><jtitle>European radiology</jtitle><stitle>Eur Radiol</stitle><addtitle>Eur Radiol</addtitle><date>2017-08-01</date><risdate>2017</risdate><volume>27</volume><issue>8</issue><spage>3542</spage><epage>3553</epage><pages>3542-3553</pages><issn>0938-7994</issn><eissn>1432-1084</eissn><abstract>Objective To prospectively compare diagnostic accuracy of fetal post-mortem whole-body MRI at 3-T vs. 1.5-T. Methods Between 2012 and 2015, post-mortem MRI at 1.5-T and 3-T was performed in fetuses after miscarriage/stillbirth or termination. Clinical MRI diagnoses were assessed using a confidence diagnostic score and compared with classical autopsy to derive a diagnostic error score. The relation of diagnostic error for each organ group with gestational age was calculated and 1.5-T with 3-T was compared with accuracy analysis. Results 135 fetuses at 12–41 weeks underwent post-mortem MRI (followed by conventional autopsy in 92 fetuses). For all organ groups except the brain, and for both modalities, the diagnostic error decreased with gestation ( P  &lt; 0.0001). 3-T MRI diagnostic error was significantly lower than that of 1.5-T for all anatomic structures and organ groups, except the orbits and brain. This difference was maintained for fetuses &lt;20 weeks gestation. Moreover, 3-T was associated with fewer non-diagnostic scans and greater concordance with classical autopsy than 1.5-T MRI, especially for the thorax, heart and abdomen in fetuses &lt;20 weeks. Conclusion Post-mortem fetal 3-T MRI improves confidence scores and overall accuracy compared with 1.5-T, mainly for the thorax, heart and abdomen of fetuses &lt;20 weeks of gestation. Key Points • In PM-MRI, diagnostic error using 3-T is lower than that with 1.5-T. • In PM-MRI, diagnostic scan rate is higher using 3-T than 1.5-T. • In PM-MRI, concordance with classical autopsy increases with 3-T. • PM-MRI using 3-T is particularly interesting for thoracic and abdominal organs. • PM-MRI using 3-T is particularly interesting for fetuses &lt; 20 weeks’ gestation.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>28116518</pmid><doi>10.1007/s00330-016-4725-4</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record>
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subjects Abdomen
Abortion, Induced
Abortion, Spontaneous - diagnostic imaging
Abortion, Spontaneous - pathology
Accuracy
Autopsies
Autopsy
Autopsy - methods
Brain
Brain - diagnostic imaging
Brain - pathology
Condoms
Diagnostic Errors
Diagnostic Radiology
Diagnostic systems
Errors
Female
Fetal Diseases - diagnostic imaging
Fetal Diseases - pathology
Fetus - diagnostic imaging
Fetus - pathology
Fetuses
Gestation
Gestational Age
Heart - diagnostic imaging
Humans
Imaging
Internal Medicine
Interventional Radiology
Magnetic Resonance
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Medicine
Medicine & Public Health
Miscarriage
Myocardium - pathology
Neuroimaging
Neuroradiology
NMR
Nuclear magnetic resonance
Organs
Pregnancy
Prospective Studies
Radiology
Stillbirth
Thorax
Thorax - diagnostic imaging
Thorax - pathology
Ultrasound
Whole Body Imaging - methods
title Post-mortem whole-body magnetic resonance imaging of human fetuses: a comparison of 3-T vs. 1.5-T MR imaging with classical autopsy
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