Enterolactone glucuronide and β-glucuronidase in antibody directed enzyme prodrug therapy for targeted prostate cancer cell treatment

Evidence from preclinical and animal studies demonstrated an anticancer effect of flaxseed lignans, particularly enterolactone (ENL), against prostate cancer. However, extensive first-pass metabolism following oral lignan consumption results in their systemic availability primarily as glucuronic aci...

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Veröffentlicht in:	AAPS PharmSciTech 2017-08, Vol.18 (6), p.2336-2345
Hauptverfasser:	Di, Yunyun, Ji, Shaoping, Wolf, Philipp, Krol, Ed S., Alcorn, Jane
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Butyrolactone - analogs & derivatives 4-Butyrolactone - therapeutic use Animals Antibodies - therapeutic use Antigens, Surface - immunology Biochemistry Biomedical and Life Sciences Biomedicine Biotechnology Cercopithecus aethiops COS Cells Glucuronidase - therapeutic use Glucuronides - therapeutic use Glutamate Carboxypeptidase II - immunology Humans Lignans - therapeutic use Male Pharmacology/Toxicology Pharmacy Prodrugs - therapeutic use Prostatic Neoplasms - drug therapy Prostatic Neoplasms - pathology Recombinant Fusion Proteins - therapeutic use Research Article
Online-Zugang:	Volltext
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