pH-sensitive niosomes: Effects on cytotoxicity and on inflammation and pain in murine models

pH-sensitive nonionic surfactant vesicles (niosomes) by polysorbate-20 (Tween-20) or polysorbate-20 derivatized by glycine (added as pH sensitive agent), were developed to deliver Ibuprofen (IBU) and Lidocaine (LID). For the physical-chemical characterization of vesicles (mean size, size distributio...

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Veröffentlicht in:	Journal of enzyme inhibition and medicinal chemistry 2017-01, Vol.32 (1), p.538-546
Hauptverfasser:	Rinaldi, Federica, Del Favero, Elena, Rondelli, Valeria, Pieretti, Stefano, Bogni, Alessia, Ponti, Jessica, Rossi, François, Di Marzio, Luisa, Paolino, Donatella, Marianecci, Carlotta, Carafa, Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Anti-inflammatory agents Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - pharmacology anti-nociceptive/anti-inflammatory activity BALB 3T3 Cells Cells, Cultured Cytotoxicity Disease Models, Animal Edema Fibroblasts Fibroblasts - drug effects Glycine Humans Hydrogen-Ion Concentration Ibuprofen Ibuprofen - administration & dosage Ibuprofen - pharmacology Inflammation Inflammation - drug therapy Lidocaine Lidocaine - administration & dosage Lidocaine - pharmacology Light scattering Liposomes - administration & dosage Liposomes - chemistry Liposomes - pharmacology Mice Pain - drug therapy Pain Measurement Pain perception pH effects pH-sensitive niosomes Size distribution Surface-Active Agents - chemistry Surface-Active Agents - pharmacology Surfactants Vesicles X-ray scattering Zeta potential
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