Preparation and extensive characterization of hyaluronan with narrow molecular weight distribution

•A simple protocol to prepare almost monodisperse hyaluronan is presented.•The process is easily up-scalable for acid and enzymatically degraded hyaluronan.•SEC-MALLS conditions were optimized with the emphasis laid on separation quality.•Novel polydispersity-related parameter called distribution an...

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Veröffentlicht in:	Carbohydrate polymers 2017-03, Vol.160, p.134-142
Hauptverfasser:	Čožíková, Dagmar, Šílová, Tereza, Moravcová, Veronika, Šmejkalová, Daniela, Pepeliaev, Stanislav, Velebný, Vladimír, Hermannová, Martina
Format:	Artikel
Sprache:	eng
Schlagworte:	Anion-exchange chromatography Hyaluronan fragmentation Molecular weight Polydispersity Size exclusion chromatography
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