Differential expression of CART in ewes with differing ovulation rates

We hypothesised that cocaine- and amphetamine-regulated transcript (CARTPT) would be differentially expressed in ewes with differing ovulation rates. Expression of mRNA for CARTPT, as well as LHCGR, FSHR, CYP19A1 and CYP17A1 was determined in antral follicles ≥1 mm in diameter collected during the f...

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Veröffentlicht in:	Reproduction (Cambridge, England) England), 2017-04, Vol.153 (4), p.471-479
Hauptverfasser:	Juengel, Jennifer L, French, Michelle C, Quirke, Laurel D, Kauff, Alexia, Smith, George W, Johnstone, Peter D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aromatase - genetics Aromatase - metabolism Estradiol - metabolism Female Follicular Fluid - metabolism Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Ovarian Follicle - cytology Ovarian Follicle - metabolism Ovulation - physiology Receptors, FSH - genetics Receptors, FSH - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Sheep Steroid 17-alpha-Hydroxylase - genetics Steroid 17-alpha-Hydroxylase - metabolism
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Zusammenfassung:	We hypothesised that cocaine- and amphetamine-regulated transcript (CARTPT) would be differentially expressed in ewes with differing ovulation rates. Expression of mRNA for CARTPT, as well as LHCGR, FSHR, CYP19A1 and CYP17A1 was determined in antral follicles ≥1 mm in diameter collected during the follicular phase in ewes heterozygous for the Booroola and Inverdale genes (I+B+; average ovulation rate 4) and ++ contemporaries (++; average ovulation rate 1.8). In ++ ewes (n = 6), CARTPT was expressed in small follicles (1 to
ISSN:	1470-1626 1741-7899
DOI:	10.1530/REP-16-0657