Serum and urinary thioredoxin concentrations are associated with severity of children hydronephrosis
Ureteropelvic junction obstruction (UPJO) is the most common cause of hydronephrosis in children. This study was to assess the relationship between serum thioredoxin (S-Trx) and urinary thioredoxin (U-Trx) concentrations and severity of children hydronephrosis caused by UPJO. This study included 156...
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| Veröffentlicht in: | Clinica chimica acta 2017-03, Vol.466, p.127-132 |
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| description | Ureteropelvic junction obstruction (UPJO) is the most common cause of hydronephrosis in children. This study was to assess the relationship between serum thioredoxin (S-Trx) and urinary thioredoxin (U-Trx) concentrations and severity of children hydronephrosis caused by UPJO.
This study included 156 hydronephrosis children with unilateral UPJO and 80 healthy children. S-Trx and U-Trx concentrations were measured using enzyme-linked immunosorbent assay. U-Trx/creatinine (cr) ratio was calculated.
S-Trx and U-Trx concentrations and U-Trx/cr ratio were significantly higher in hydronephrosis children than in healthy children. They were significantly correlated with split renal function, anterior–posterior diameter and Society for Fetal Urology classification, as well as were independently related to the split renal function 30mm and Society for Fetal Urology grade IV. Under receiver operating characteristic curves, U-Trx/cr ratio showed the higher predictive value compared to S-Trx and U-Trx concentrations.
Increased S-Trx and U-Trx concentrations, especially U-Trx/cr ratio, are closely associated with the severity of children hydronephrosis, substantializing Trx as a promising biomarker for the progression of children hydronephrosis.
•S-Trx and U-Trx levels and U-Trx/cr ratio are significantly elevated in hydronephrosis children.•S-Trx and U-Trx levels and U-Trx/cr ratio are highly correlated with the severity.•S-Trx and U-Trx levels and U-Trx/cr ratio have high discriminative ability for the severity. |
| doi_str_mv | 10.1016/j.cca.2017.01.020 |
| format | Article |
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This study included 156 hydronephrosis children with unilateral UPJO and 80 healthy children. S-Trx and U-Trx concentrations were measured using enzyme-linked immunosorbent assay. U-Trx/creatinine (cr) ratio was calculated.
S-Trx and U-Trx concentrations and U-Trx/cr ratio were significantly higher in hydronephrosis children than in healthy children. They were significantly correlated with split renal function, anterior–posterior diameter and Society for Fetal Urology classification, as well as were independently related to the split renal function <39.2%, anterior–posterior diameter>30mm and Society for Fetal Urology grade IV. Under receiver operating characteristic curves, U-Trx/cr ratio showed the higher predictive value compared to S-Trx and U-Trx concentrations.
Increased S-Trx and U-Trx concentrations, especially U-Trx/cr ratio, are closely associated with the severity of children hydronephrosis, substantializing Trx as a promising biomarker for the progression of children hydronephrosis.
•S-Trx and U-Trx levels and U-Trx/cr ratio are significantly elevated in hydronephrosis children.•S-Trx and U-Trx levels and U-Trx/cr ratio are highly correlated with the severity.•S-Trx and U-Trx levels and U-Trx/cr ratio have high discriminative ability for the severity.</description><identifier>ISSN: 0009-8981</identifier><identifier>EISSN: 1873-3492</identifier><identifier>DOI: 10.1016/j.cca.2017.01.020</identifier><identifier>PMID: 28111273</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Biomarkers - analysis ; Case-Control Studies ; Child ; Child, Preschool ; Children ; Creatinine - analysis ; Disease Progression ; Humans ; Hydronephrosis ; Hydronephrosis - blood ; Hydronephrosis - diagnosis ; Hydronephrosis - etiology ; Hydronephrosis - urine ; Severity of Illness Index ; Thioredoxin ; Thioredoxins - analysis ; Thioredoxins - blood ; Thioredoxins - urine ; Ureteral Obstruction - complications ; Ureteropelvic junction obstruction</subject><ispartof>Clinica chimica acta, 2017-03, Vol.466, p.127-132</ispartof><rights>2017 Elsevier B.V.</rights><rights>Copyright © 2017 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-820ac586b37c14d3c051988fd8b03c692b744c85ca28e5fa9c7dc63e7bc46dc53</citedby><cites>FETCH-LOGICAL-c353t-820ac586b37c14d3c051988fd8b03c692b744c85ca28e5fa9c7dc63e7bc46dc53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cca.2017.01.020$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28111273$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xu, Zhe-Ming</creatorcontrib><creatorcontrib>Li, Min-Ju</creatorcontrib><creatorcontrib>Tao, Chang</creatorcontrib><title>Serum and urinary thioredoxin concentrations are associated with severity of children hydronephrosis</title><title>Clinica chimica acta</title><addtitle>Clin Chim Acta</addtitle><description>Ureteropelvic junction obstruction (UPJO) is the most common cause of hydronephrosis in children. This study was to assess the relationship between serum thioredoxin (S-Trx) and urinary thioredoxin (U-Trx) concentrations and severity of children hydronephrosis caused by UPJO.
This study included 156 hydronephrosis children with unilateral UPJO and 80 healthy children. S-Trx and U-Trx concentrations were measured using enzyme-linked immunosorbent assay. U-Trx/creatinine (cr) ratio was calculated.
S-Trx and U-Trx concentrations and U-Trx/cr ratio were significantly higher in hydronephrosis children than in healthy children. They were significantly correlated with split renal function, anterior–posterior diameter and Society for Fetal Urology classification, as well as were independently related to the split renal function <39.2%, anterior–posterior diameter>30mm and Society for Fetal Urology grade IV. Under receiver operating characteristic curves, U-Trx/cr ratio showed the higher predictive value compared to S-Trx and U-Trx concentrations.
Increased S-Trx and U-Trx concentrations, especially U-Trx/cr ratio, are closely associated with the severity of children hydronephrosis, substantializing Trx as a promising biomarker for the progression of children hydronephrosis.
•S-Trx and U-Trx levels and U-Trx/cr ratio are significantly elevated in hydronephrosis children.•S-Trx and U-Trx levels and U-Trx/cr ratio are highly correlated with the severity.•S-Trx and U-Trx levels and U-Trx/cr ratio have high discriminative ability for the severity.</description><subject>Biomarkers - analysis</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Creatinine - analysis</subject><subject>Disease Progression</subject><subject>Humans</subject><subject>Hydronephrosis</subject><subject>Hydronephrosis - blood</subject><subject>Hydronephrosis - diagnosis</subject><subject>Hydronephrosis - etiology</subject><subject>Hydronephrosis - urine</subject><subject>Severity of Illness Index</subject><subject>Thioredoxin</subject><subject>Thioredoxins - analysis</subject><subject>Thioredoxins - blood</subject><subject>Thioredoxins - urine</subject><subject>Ureteral Obstruction - complications</subject><subject>Ureteropelvic junction obstruction</subject><issn>0009-8981</issn><issn>1873-3492</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v1DAQhi1URJfCD-il8pFLgifOhyNOVdUCUiUOwNlyxhPFq117sZ2W_fd1tYVjT6ORnvfVzMPYJYgaBPSftzWiqRsBQy2gFo14wzagBlnJdmzO2EYIMVZqVHDO3qe0LWsrenjHzhsFAM0gN8z-pLjuufGWr9F5E488Ly5EsuGv8xyDR_I5muyCT9xE4ialgM5ksvzR5YUneqDo8pGHmePidjaS58vRxuDpsMSQXPrA3s5ml-jjy7xgv-9uf918q-5_fP1-c31foexkrlQjDHaqn-SA0FqJooNRqdmqSUjsx2Ya2hZVh6ZR1M1mxMFiL2mYsO0tdvKCfTr1HmL4s1LKeu8S0m5nPIU1aVA9dGPXQltQOKFYLkyRZn2Ibl_e1yD0s1y91UWufparBegit2SuXurXaU_2f-KfzQJ8OQFUnnxwFHVCR8WgdZEwaxvcK_VP5xmMRA</recordid><startdate>201703</startdate><enddate>201703</enddate><creator>Xu, Zhe-Ming</creator><creator>Li, Min-Ju</creator><creator>Tao, Chang</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201703</creationdate><title>Serum and urinary thioredoxin concentrations are associated with severity of children hydronephrosis</title><author>Xu, Zhe-Ming ; Li, Min-Ju ; Tao, Chang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-820ac586b37c14d3c051988fd8b03c692b744c85ca28e5fa9c7dc63e7bc46dc53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Biomarkers - analysis</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Creatinine - analysis</topic><topic>Disease Progression</topic><topic>Humans</topic><topic>Hydronephrosis</topic><topic>Hydronephrosis - blood</topic><topic>Hydronephrosis - diagnosis</topic><topic>Hydronephrosis - etiology</topic><topic>Hydronephrosis - urine</topic><topic>Severity of Illness Index</topic><topic>Thioredoxin</topic><topic>Thioredoxins - analysis</topic><topic>Thioredoxins - blood</topic><topic>Thioredoxins - urine</topic><topic>Ureteral Obstruction - complications</topic><topic>Ureteropelvic junction obstruction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xu, Zhe-Ming</creatorcontrib><creatorcontrib>Li, Min-Ju</creatorcontrib><creatorcontrib>Tao, Chang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinica chimica acta</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, Zhe-Ming</au><au>Li, Min-Ju</au><au>Tao, Chang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum and urinary thioredoxin concentrations are associated with severity of children hydronephrosis</atitle><jtitle>Clinica chimica acta</jtitle><addtitle>Clin Chim Acta</addtitle><date>2017-03</date><risdate>2017</risdate><volume>466</volume><spage>127</spage><epage>132</epage><pages>127-132</pages><issn>0009-8981</issn><eissn>1873-3492</eissn><abstract>Ureteropelvic junction obstruction (UPJO) is the most common cause of hydronephrosis in children. This study was to assess the relationship between serum thioredoxin (S-Trx) and urinary thioredoxin (U-Trx) concentrations and severity of children hydronephrosis caused by UPJO.
This study included 156 hydronephrosis children with unilateral UPJO and 80 healthy children. S-Trx and U-Trx concentrations were measured using enzyme-linked immunosorbent assay. U-Trx/creatinine (cr) ratio was calculated.
S-Trx and U-Trx concentrations and U-Trx/cr ratio were significantly higher in hydronephrosis children than in healthy children. They were significantly correlated with split renal function, anterior–posterior diameter and Society for Fetal Urology classification, as well as were independently related to the split renal function <39.2%, anterior–posterior diameter>30mm and Society for Fetal Urology grade IV. Under receiver operating characteristic curves, U-Trx/cr ratio showed the higher predictive value compared to S-Trx and U-Trx concentrations.
Increased S-Trx and U-Trx concentrations, especially U-Trx/cr ratio, are closely associated with the severity of children hydronephrosis, substantializing Trx as a promising biomarker for the progression of children hydronephrosis.
•S-Trx and U-Trx levels and U-Trx/cr ratio are significantly elevated in hydronephrosis children.•S-Trx and U-Trx levels and U-Trx/cr ratio are highly correlated with the severity.•S-Trx and U-Trx levels and U-Trx/cr ratio have high discriminative ability for the severity.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>28111273</pmid><doi>10.1016/j.cca.2017.01.020</doi><tpages>6</tpages></addata></record> |
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| subjects | Biomarkers - analysis Case-Control Studies Child Child, Preschool Children Creatinine - analysis Disease Progression Humans Hydronephrosis Hydronephrosis - blood Hydronephrosis - diagnosis Hydronephrosis - etiology Hydronephrosis - urine Severity of Illness Index Thioredoxin Thioredoxins - analysis Thioredoxins - blood Thioredoxins - urine Ureteral Obstruction - complications Ureteropelvic junction obstruction |
| title | Serum and urinary thioredoxin concentrations are associated with severity of children hydronephrosis |
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