Induction and suppression of type I interferon responses by mink enteritis virus in CRFK cells

•MEV neither induced nor was sensitive to the effects of type I interferon.•The nonstructural protein (NS1) of MEV inhibits IFN induction.•The ORI-binding domain of NS1 protein suppresses IFNβ expression. Mink enteritis virus (MEV) is one of the most important viral pathogens causing serious disease...

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Veröffentlicht in:	Veterinary microbiology 2017-02, Vol.199, p.8-14
Hauptverfasser:	Zhang, Xiaomei, Wang, Jigui, Mao, Yaping, Xi, Ji, Yu, Yongle, Liu, Weiquan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cats Cell Line Enteritis Feline Panleukopenia - immunology Gene Expression Regulation - drug effects Infections Innate immunity Interferon Interferon Inducers - pharmacology Interferon Type I - immunology Mink enteritis parvovirus Mink enteritis virus - physiology Nonstructural protein ORI-binding domain Pathogens Poly (I:C) Poly I-C - pharmacology Type I interferon Viral infections Viral Nonstructural Proteins - metabolism Virus Replication Viruses
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