Induction and suppression of type I interferon responses by mink enteritis virus in CRFK cells
•MEV neither induced nor was sensitive to the effects of type I interferon.•The nonstructural protein (NS1) of MEV inhibits IFN induction.•The ORI-binding domain of NS1 protein suppresses IFNβ expression. Mink enteritis virus (MEV) is one of the most important viral pathogens causing serious disease...
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| Veröffentlicht in: | Veterinary microbiology 2017-02, Vol.199, p.8-14 |
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| container_title | Veterinary microbiology |
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| creator | Zhang, Xiaomei Wang, Jigui Mao, Yaping Xi, Ji Yu, Yongle Liu, Weiquan |
| description | •MEV neither induced nor was sensitive to the effects of type I interferon.•The nonstructural protein (NS1) of MEV inhibits IFN induction.•The ORI-binding domain of NS1 protein suppresses IFNβ expression.
Mink enteritis virus (MEV) is one of the most important viral pathogens causing serious disease in mink. Type I interferon (IFN) plays a critical role in antiviral innate immunity and, for successful infection, many viruses have evolved evasive strategies against it. Here, we show that MEV infection does not evoke IFN or interferon-stimulated genes (ISGs) responses in feline kidney (CRFK) cells, and that MEV suppresses IFN production in both poly I:C-stimulated and untreated cells. In CRFK cells pre-exposure to IFN, show that infection with, and replication of, MEV remain unaffected. This inhibition appears to be mediated by the MEV nonstructural protein (NS1) with its ORI-binding domain playing a major role. |
| doi_str_mv | 10.1016/j.vetmic.2016.12.002 |
| format | Article |
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Mink enteritis virus (MEV) is one of the most important viral pathogens causing serious disease in mink. Type I interferon (IFN) plays a critical role in antiviral innate immunity and, for successful infection, many viruses have evolved evasive strategies against it. Here, we show that MEV infection does not evoke IFN or interferon-stimulated genes (ISGs) responses in feline kidney (CRFK) cells, and that MEV suppresses IFN production in both poly I:C-stimulated and untreated cells. In CRFK cells pre-exposure to IFN, show that infection with, and replication of, MEV remain unaffected. This inhibition appears to be mediated by the MEV nonstructural protein (NS1) with its ORI-binding domain playing a major role.</description><identifier>ISSN: 0378-1135</identifier><identifier>EISSN: 1873-2542</identifier><identifier>DOI: 10.1016/j.vetmic.2016.12.002</identifier><identifier>PMID: 28110790</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Cats ; Cell Line ; Enteritis ; Feline Panleukopenia - immunology ; Gene Expression Regulation - drug effects ; Infections ; Innate immunity ; Interferon ; Interferon Inducers - pharmacology ; Interferon Type I - immunology ; Mink enteritis parvovirus ; Mink enteritis virus - physiology ; Nonstructural protein ; ORI-binding domain ; Pathogens ; Poly (I:C) ; Poly I-C - pharmacology ; Type I interferon ; Viral infections ; Viral Nonstructural Proteins - metabolism ; Virus Replication ; Viruses</subject><ispartof>Veterinary microbiology, 2017-02, Vol.199, p.8-14</ispartof><rights>2016 Elsevier B.V.</rights><rights>Copyright © 2016 Elsevier B.V. All rights reserved.</rights><rights>Copyright Elsevier BV Feb 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-800059e987fc9574c2a0a029879aa41366829a8d68bd917f41da29c19c2407133</citedby><cites>FETCH-LOGICAL-c390t-800059e987fc9574c2a0a029879aa41366829a8d68bd917f41da29c19c2407133</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.vetmic.2016.12.002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28110790$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Xiaomei</creatorcontrib><creatorcontrib>Wang, Jigui</creatorcontrib><creatorcontrib>Mao, Yaping</creatorcontrib><creatorcontrib>Xi, Ji</creatorcontrib><creatorcontrib>Yu, Yongle</creatorcontrib><creatorcontrib>Liu, Weiquan</creatorcontrib><title>Induction and suppression of type I interferon responses by mink enteritis virus in CRFK cells</title><title>Veterinary microbiology</title><addtitle>Vet Microbiol</addtitle><description>•MEV neither induced nor was sensitive to the effects of type I interferon.•The nonstructural protein (NS1) of MEV inhibits IFN induction.•The ORI-binding domain of NS1 protein suppresses IFNβ expression.
Mink enteritis virus (MEV) is one of the most important viral pathogens causing serious disease in mink. Type I interferon (IFN) plays a critical role in antiviral innate immunity and, for successful infection, many viruses have evolved evasive strategies against it. Here, we show that MEV infection does not evoke IFN or interferon-stimulated genes (ISGs) responses in feline kidney (CRFK) cells, and that MEV suppresses IFN production in both poly I:C-stimulated and untreated cells. In CRFK cells pre-exposure to IFN, show that infection with, and replication of, MEV remain unaffected. This inhibition appears to be mediated by the MEV nonstructural protein (NS1) with its ORI-binding domain playing a major role.</description><subject>Animals</subject><subject>Cats</subject><subject>Cell Line</subject><subject>Enteritis</subject><subject>Feline Panleukopenia - immunology</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Infections</subject><subject>Innate immunity</subject><subject>Interferon</subject><subject>Interferon Inducers - pharmacology</subject><subject>Interferon Type I - immunology</subject><subject>Mink enteritis parvovirus</subject><subject>Mink enteritis virus - physiology</subject><subject>Nonstructural protein</subject><subject>ORI-binding domain</subject><subject>Pathogens</subject><subject>Poly (I:C)</subject><subject>Poly I-C - pharmacology</subject><subject>Type I interferon</subject><subject>Viral infections</subject><subject>Viral Nonstructural Proteins - metabolism</subject><subject>Virus Replication</subject><subject>Viruses</subject><issn>0378-1135</issn><issn>1873-2542</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM-L1DAUx4Mo7uy6_4FIwIuX1rw0bZOLIIO7Di4IotcNmfQVMk7TmtcOzH9vyqwePHgK37zP-8GHsdcgShDQvD-UJ5yH4EuZUwmyFEI-YxvQbVXIWsnnbCOqVhcAVX3FrokOQghlGvGSXUkNIFojNuxxF7vFz2GM3MWO0zJNCYnWPPZ8Pk_IdzzEGVOPKX_m4jRGQuL7Mx9C_MlxLYY5ED-FtFCG-fbb3Rfu8XikV-xF746Et0_vDftx9-n79nPx8PV-t_34UPjKiLnQ-bTaoNFt703dKi-dcELmbJxTUDWNlsbprtH7zkDbK-icNB6Ml0q0UFU37N1l7pTGXwvSbIdA6wUu4riQBd1AbVRdy4y-_Qc9jEuK-ToLpqmyLa1MptSF8mkkStjbKYXBpbMFYVf_9mAv_u3q34K02X9ue_M0fNkP2P1t-iM8Ax8uAGYbp4DJkg8YPXYhoZ9tN4b_b_gNQU6W0g</recordid><startdate>201702</startdate><enddate>201702</enddate><creator>Zhang, Xiaomei</creator><creator>Wang, Jigui</creator><creator>Mao, Yaping</creator><creator>Xi, Ji</creator><creator>Yu, Yongle</creator><creator>Liu, Weiquan</creator><general>Elsevier B.V</general><general>Elsevier BV</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>201702</creationdate><title>Induction and suppression of type I interferon responses by mink enteritis virus in CRFK cells</title><author>Zhang, Xiaomei ; Wang, Jigui ; Mao, Yaping ; Xi, Ji ; Yu, Yongle ; Liu, Weiquan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-800059e987fc9574c2a0a029879aa41366829a8d68bd917f41da29c19c2407133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Cats</topic><topic>Cell Line</topic><topic>Enteritis</topic><topic>Feline Panleukopenia - immunology</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Infections</topic><topic>Innate immunity</topic><topic>Interferon</topic><topic>Interferon Inducers - pharmacology</topic><topic>Interferon Type I - immunology</topic><topic>Mink enteritis parvovirus</topic><topic>Mink enteritis virus - physiology</topic><topic>Nonstructural protein</topic><topic>ORI-binding domain</topic><topic>Pathogens</topic><topic>Poly (I:C)</topic><topic>Poly I-C - pharmacology</topic><topic>Type I interferon</topic><topic>Viral infections</topic><topic>Viral Nonstructural Proteins - metabolism</topic><topic>Virus Replication</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Xiaomei</creatorcontrib><creatorcontrib>Wang, Jigui</creatorcontrib><creatorcontrib>Mao, Yaping</creatorcontrib><creatorcontrib>Xi, Ji</creatorcontrib><creatorcontrib>Yu, Yongle</creatorcontrib><creatorcontrib>Liu, Weiquan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Xiaomei</au><au>Wang, Jigui</au><au>Mao, Yaping</au><au>Xi, Ji</au><au>Yu, Yongle</au><au>Liu, Weiquan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Induction and suppression of type I interferon responses by mink enteritis virus in CRFK cells</atitle><jtitle>Veterinary microbiology</jtitle><addtitle>Vet Microbiol</addtitle><date>2017-02</date><risdate>2017</risdate><volume>199</volume><spage>8</spage><epage>14</epage><pages>8-14</pages><issn>0378-1135</issn><eissn>1873-2542</eissn><abstract>•MEV neither induced nor was sensitive to the effects of type I interferon.•The nonstructural protein (NS1) of MEV inhibits IFN induction.•The ORI-binding domain of NS1 protein suppresses IFNβ expression.
Mink enteritis virus (MEV) is one of the most important viral pathogens causing serious disease in mink. Type I interferon (IFN) plays a critical role in antiviral innate immunity and, for successful infection, many viruses have evolved evasive strategies against it. Here, we show that MEV infection does not evoke IFN or interferon-stimulated genes (ISGs) responses in feline kidney (CRFK) cells, and that MEV suppresses IFN production in both poly I:C-stimulated and untreated cells. In CRFK cells pre-exposure to IFN, show that infection with, and replication of, MEV remain unaffected. This inhibition appears to be mediated by the MEV nonstructural protein (NS1) with its ORI-binding domain playing a major role.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>28110790</pmid><doi>10.1016/j.vetmic.2016.12.002</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Cats Cell Line Enteritis Feline Panleukopenia - immunology Gene Expression Regulation - drug effects Infections Innate immunity Interferon Interferon Inducers - pharmacology Interferon Type I - immunology Mink enteritis parvovirus Mink enteritis virus - physiology Nonstructural protein ORI-binding domain Pathogens Poly (I:C) Poly I-C - pharmacology Type I interferon Viral infections Viral Nonstructural Proteins - metabolism Virus Replication Viruses |
| title | Induction and suppression of type I interferon responses by mink enteritis virus in CRFK cells |
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